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2. Guaiane-type sesquiterpenes fromCurcuma wenyujinand their inhibitory effects on nitric oxide production

Author

Yan Lou, Kaifeng Peng, Feng Qiu, Hao He, Lixia Chen, Feng Zhao, and Xiao-Hua Zhou

Subjects
Lipopolysaccharides, Stereochemistry, Pharmaceutical Science, Pharmacognosy, Nitric Oxide, Sesquiterpene, Analytical Chemistry, Nitric oxide, Mice, Sesquiterpenes, Guaiane, chemistry.chemical_compound, Curcuma, Drug Discovery, Animals, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, chemistry.chemical_classification, Molecular Structure, biology, Macrophages, Organic Chemistry, Stereoisomerism, Biological activity, General Medicine, biology.organism_classification, Terpenoid, Rhizome, Complementary and alternative medicine, chemistry, Molecular Medicine, Zingiberaceae, Lactone, Drugs, Chinese Herbal
Abstract

Four new guaiane-type sesquiterpenes (1S,4S,5S,10R)-zedoarondiol, zedoalactones D, E, and F (1-4), along with 10 known ones (5-14), were isolated from Curcuma wenyujin Y.H. Chen et C. Ling. The structures of these new compounds were elucidated by spectroscopic methods. The inhibitory effects of compounds 1-14 on nitric oxide production in lipopolysaccharide-activated macrophages were evaluated.

Published
2009

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