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Acute graft-versus-host-disease (aGVHD) is a complication after allogeneic stem cell transplant. After the failure of treatment with high dose corticosteroids, steroid-refractory aGVHD (SR aGVHD) is associated with high rates of mortality. Tocilizumab has evidence of activity in SR aGVHD. For patients ineligible for trials, the OSU James Comprehensive Cancer Center has been utilizing tocilizumab as first-line therapy for SR aGVHD. We retrospectively report on 15 patients who received tocilizumab. aGVHD grading and responses were based on consensus criteria. Median age at transplant was 49 years. Median time to tocilizumab administration was 9 days (range, 3-16). Six patients had complete responses (40%) with a resolution of aGVHD. From the last contact, median overall survival for responders was not yet reached vs. 31 days for non-responders (

Autologous hematopoietic stem cell transplant (autoHSCT) remains standard of care for fit patients with multiple myeloma [1]. The use of granulocyte colony-stimulating factor (G-CSF) after autoHSCT...

An extremely sensitive catalytic voltammetric peak of Emodin at −0.59 V (vs. SCE) was obtained in 0.40 M NH4Cl–NH3 · H2 O buffer (pH 8.2) in the presence of dissolved oxygen at a carbon paste electrode (CPE). The experimental results showed that Emodin was efficiently accumulated at a CPE by adsorption. In the following potential scan, Emodin was reduced to homologous anthrahydroquinone compound, then the compound was immediately oxidized to Emodin by the dissolved oxygen in the solution, and the Emodin was again reduced at the CPE. As a result, a cyclic catalytic reaction was established. At the optimal conditions, the peak current is linearly proportional to the Emodin concentration in the range of 3.0×10−10 M∼4.0×10−9 M (accumulation 70 s) and 4.0×10−9 M∼4.0×10−8 M (accumulation 30 s). The detection limit is 1.0×10−10 M for a 90 s accumulation. The proposed method was successfully applied to determine Emodin in Polygonum multiflorum Thunb. The results are consistent with results obtained by HPLC.

A sensitive adsorptive stripping voltammetric procedure for trace measurement of thorium, based on the oxidation peak of thorium(IV)–alizarin complexan complex at a carbon paste electrode (CPE) during a positive-going potential scan from −0.1 V to 0.9 V (vs. SCE), is described. Optimum experiment conditions include the use of 0.12 M acetate–0.03 M potassium biphthalate buffer solution (pH4.6), 3.2 × 10−6 M alizarin complexon (ALC), an accumulation potential of −0.1 V, and a scan rate of 150 mV s−1. The detection limit after a 180 s preconcentration is 4.0 × 10−10 M (S/N=3), a linear current–concentration relationship is observed up to 3.0 × 10−7 M, and the relative standard deviation is 4.2% for 15 successive determinations on the same electrode surface at the 4.0 × 10−8 M level. Possible interferences are evaluated. The electrode processes of the adsorbed complex are proposed. The method has been applied to determination of trace thorium in ores with good results.

A highly selective, sensitive, rapid and economic adsorptive stripping voltammetric method has been developed for the determination of ultra trace amount of scandium at a carbon paste electrode (CPE) in the current paper. The Sc(III)−alizarin complexan (ALC) complex is adsorbed at the electrode in a mixed buffer solution (pH 5.4) containing 0.04 M acetate and 0.016 M biphthalate, yielding one peak corresponding to the reduction of ALC in the complex at −0.60 V (vs. SCE). The second-order derivative linear scan voltammograms of the complex are recorded by use of model JP−303 polarographic analyzer from −0.10 to −1.10 V. A linear relationship between the second order derivative peak current and Sc(III) concentration in the range of 1.0 × 10−9 to 6.0 × 10−7 M is observed. The detection limit for Sc(III) is 6.0 × 10−10 M. A relative standard deviation of 4.34% is given for ten determinations of 6.0 × 10−8 M Sc(III). The method has been applied to the determination of the trace Sc(III) in the mineral ...