11 results on '"José L. Arias"'
Search Results
2. Ultrasound-guided percutaneous electrical stimulation for a patient with cubital tunnel syndrome: a case report with a one-year follow-up
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Joshua A. Cleland, César Fernández-de-las-Peñas, José L. Arias-Buría, Youssef Rahou El Bachiri, and Gustavo Plaza-Manzano
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Male ,030506 rehabilitation ,medicine.medical_specialty ,Weakness ,Percutaneous ,One year follow up ,Cubital Tunnel Syndrome ,Physical Therapy, Sports Therapy and Rehabilitation ,Stimulation ,Ulnar neuropathy ,03 medical and health sciences ,Cubital tunnel syndrome ,0302 clinical medicine ,Humans ,Medicine ,Ulnar nerve ,Ulnar Nerve ,Ultrasonography, Interventional ,business.industry ,Middle Aged ,Decompression, Surgical ,medicine.disease ,Electric Stimulation ,Ultrasound guided ,Surgery ,body regions ,medicine.symptom ,0305 other medical science ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Patients with ulnar neuropathy usually experience sensory disturbances, weakness, and decreased function; however, optimal treatment approaches for this condition are not conclusive.A 48-year-old male with cubital tunnel syndrome was previously managed with a multimodal approach including splinting, neural mobilizations, and exercises with no change in symptoms. Approximately 1 year after the initial onset, he received three sessions of ultrasound-guided percutaneous electrical stimulation (PENS) and self-neural glides as a home program.After PENS intervention, the patient experienced a dramatic improvement in function and symptoms as measured by the Disabilities of the Arm, Shoulder and Hand Outcome Measure (DASH) and self-reported version of the Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) pain scale as outcomes. These improvements were maintained after 1, 3, 6, and 12 months. The patient also experienced self-perceived improvement in his condition as measured by the Global Rating of Change (GROC) at each follow-up.A patient with ulnar nerve entrapment at the elbow did not respond to a multimodal conservative care for the previous year. Once the patient was treated with ultrasound-guided PENS targeting the ulnar nerve, full functional recovery and resolution of symptoms were documented. Future clinical studies should examine the effects of PENS in managing neural entrapment syndromes on a statistically powered sample of patients.
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- 2020
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3. A Teaching Games for Understanding Program to Deal With Reasons for Dropout in Under-11 Football
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José L. Arias-Estero, Carmen Barquero-Ruiz, and María T. Morales-Belando
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Adolescent ,media_common.quotation_subject ,education ,Football ,030209 endocrinology & metabolism ,Physical Therapy, Sports Therapy and Rehabilitation ,03 medical and health sciences ,0302 clinical medicine ,Teaching games for understanding ,Soccer ,Mathematics education ,Humans ,Learning ,Orthopedics and Sports Medicine ,Dropout (neural networks) ,media_common ,Motivation ,Sport Pedagogy ,ComputingMilieux_PERSONALCOMPUTING ,Mentoring ,030229 sport sciences ,General Medicine ,Nephrology ,Psychology ,human activities ,Autonomy - Abstract
Young players report that they dropout of organized football due to excessive emphasis on technical execution, low success, and the lack of autonomy and motivation experienced by players during training sessions.
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- 2020
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4. Prediction model for the inclusion of key competences in the primary school curriculum through the teachers’ perceptions in the Region de Murcia / Modelo de predicción para la inclusión de las competencias en el currículo de educación primaria según la percepción del profesorado de la Región de Murcia
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Antonio Calderón, Lourdes Meroño, Antonio Méndez-Giménez, and José L. Arias-Estero
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Cultural Studies ,School teachers ,05 social sciences ,050301 education ,Sociology ,0509 other social sciences ,050905 science studies ,0503 education ,Curriculum ,Humanities ,Inclusion (education) ,Education - Abstract
The purposes of this paper were twofold: (a) to analyse primary school teachers’ perceptions of the inclusion of the key competences in the curriculum; and (b) to test a hypothetical prediction mod...
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- 2019
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5. Effect of the ball mass on the one-on-one game situation in 9–11 year old boys' basketball
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Francisco M. Argudo, José L. Arias, and José I. Alonso
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Game analysis ,Basketball ,Team sport ,Applied psychology ,Ball (bearing) ,Orthopedics and Sports Medicine ,Physical Therapy, Sports Therapy and Rehabilitation ,General Medicine ,Psychology - Abstract
Children normally lack the strength and physical characteristics required to use the equipment and rules of adult sports. Studies that utilise a test have shown that changes in the ball mass may improve shot performance and other ball handling skills. The objective of this study was to analyse with which ball participants played a higher number of one-on-one situations in basketball. The participants were 54 nine to eleven-year-old boys from six teams. We established three situations in which the participants played four games with each of the following balls: (a) regulation ball (485 g, 69–71 cm), (b) ball of smaller mass (440 g, 69–71 cm), and (c) ball of greater mass (540 g, 69–71 cm). The procedures that were followed were: (a) defining the variable, the dependent variable was the number of one-on-one situations; (b) instructing the observers and obtaining reliability, reliability was above 0.95; (c) monitoring the properties of the ball and filming the games; and (d) recording (four observer...
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- 2012
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6. Chitosan nanoparticles as a new delivery system for the chemotherapy agent tegafur
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María Adolfina Ruiz, José L. Arias, Margarita López-Viota, and Visitación Gallardo
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Drug ,Antimetabolites, Antineoplastic ,media_common.quotation_subject ,Pharmaceutical Science ,macromolecular substances ,Pharmacology ,Tegafur ,Chitosan ,chemistry.chemical_compound ,Drug Delivery Systems ,Adsorption ,Pharmacokinetics ,Drug Discovery ,medicine ,media_common ,Organic Chemistry ,technology, industry, and agriculture ,Controlled release ,Combinatorial chemistry ,Biodegradable polymer ,chemistry ,Nanoparticles ,Drug carrier ,medicine.drug - Abstract
Despite the very efficient antitumor activity of conventional chemotherapy, generally high doses of anticancer molecules must be administered to obtain the required therapeutic action, simultaneously leading to severe side effects. This is frequently a consequence of the development of multidrug resistance by cancer cells and of the poor pharmacokinetic profile of these agents.In Order to improve the antitumor effect of tegafur and overcome their important drawbacks, we have investigated its incorporation into a drug nanoplatform based on the biodegradable polymer chitosan.Two tegafur loading methods were studied: (i) absorption into the polymeric network (entrapment procedure); and (ii) surface deposition (adsorption procedure) in already formed chitosan nanoparticles.Tegafur entrapment into the polymeric matrix has yielded higher drug loading values and a slower drug release profile, compared to single surface adsorption. The main factores determining the drug loading to chitosan were identified.Such polymeric colloid present very interesting properties for efficient tegafur delivery to cancer.
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- 2010
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7. Effect of the 3-Point Line Change on the Game Dynamics in Girls' Minibasketball
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José I. Alonso, Francisco M. Argudo, and José L. Arias
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Competitive Behavior ,Game dynamics ,Decision Making ,Age Factors ,Reproducibility of Results ,Physical Therapy, Sports Therapy and Rehabilitation ,Basketball ,General Medicine ,Nephrology ,Task Performance and Analysis ,Statistics ,Humans ,Female ,Orthopedics and Sports Medicine ,Ball (mathematics) ,Child ,Psychology ,Social psychology - Abstract
We examined the game dynamics in minibasketball when comparing two different forms of the 3-point line. During the first competition, participants used a 3-point line delimited by the free-throw lane, and 1,642 ball possessions were recorded. During the second competition, participants played with a 3-point line delimited by a rectangular area, and 1,669 ball possessions were recorded. Results from the Mann-Whitney U Test show that when playing with a 3-point line delimited by the free-throw lane, higher average values were achieved in terms of points scored, number of players taking part in the ball possessions, number of passes, and one-on-one situations.
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- 2009
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8. Polymeric nanoparticulate system augmented the anticancer therapeutic efficacy of gemcitabine
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José L. Arias, L. Harivardhan Reddy, and Patrick Couvreur
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Drug ,Antimetabolites, Antineoplastic ,Polymers ,medicine.drug_class ,media_common.quotation_subject ,Pharmaceutical Science ,Pharmacology ,Deoxycytidine ,Antimetabolite ,Gemcitabine Hydrochloride ,Mice ,medicine ,Animals ,Cyanoacrylates ,Leukemia L1210 ,Cytotoxicity ,media_common ,Drug Carriers ,Nucleoside analogue ,business.industry ,Hydrogen-Ion Concentration ,Gemcitabine ,Controlled release ,Biochemistry ,Mice, Inbred DBA ,Injections, Intravenous ,Nanoparticles ,Drug carrier ,business ,medicine.drug - Abstract
Gemcitabine hydrochloride is an anticancer nucleoside analogue indicated in clinic for the treatment of various solid tumors. Although this drug has been demonstrated to display anticancer activity against a wide variety of tumors, it is needed to be administered at high doses to elicit the required therapeutic response, simultaneously leading to severe adverse effects. We hypothesized that the efficient delivery of gemcitabine to tumors using a biodegradable carrier system could reduce the dose required to elicit sufficient therapeutic response. Thus, we have developed a nanoparticle formulation of gemcitabine suitable for parenteral administration based on the biodegradable polymer poly(octylcyanoacrylate) (POCA). The nanoparticles were synthesized by anionic polymerization of the corresponding monomer. Two drug loading methods were analyzed: the first one based on gemcitabine surface adsorption onto the preformed nanoparticles, and the second method being gemcitabine addition before the polymerization process leading to drug entrapment in the polymeric network. A detailed investigation of the capabilities of the polymer particles to load this drug is described. Gemcitabine entrapment into the polymer matrix yielded a higher drug loading and a slower drug release profile as compared with drug adsorption procedure. The main factors determining the gemcitabine incorporation to the polymer network were the nanoparticles preparation procedure, the monomer concentration, the surfactant concentration, the pH, and the drug concentration. The release kinetic of gemcitabine was found to be controlled by the pH and the type of drug incorporation. The cytotoxicity studies performed on L1210 tumor cells revealed a similar anticancer activity of the gemcitabine-loaded POCA (GPOCA) nanoparticle as free gemcitabine. Following intravenous administration into the mice bearing L1210 wt subcutaneous tumor, the GPOCA nanoparticles displayed significantly greater anticancer activity compared to free gemcitabine; this has been additionally confirmed by histology and immunohistochemistry studies, suggesting the potential of GPOCA for the efficient treatment of cancer.
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- 2009
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9. Enhanced antitumoral activity of doxorubicin against lung cancer cells using biodegradable poly(butylcyanoacrylate) nanoparticles
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Jose Prados, José L. Arias, Laura Cabeza, Octavio Caba, Ángel V. Delgado, Raúl Ortiz, Ana R. Rama, and Consolación Melguizo
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Drug ,Lung Neoplasms ,Surface Properties ,media_common.quotation_subject ,medicine.medical_treatment ,Pharmaceutical Science ,Adenocarcinoma of Lung ,Antineoplastic Agents ,Biocompatible Materials ,Adenocarcinoma ,Pharmacology ,cancer chemotherapy ,Mice ,Structure-Activity Relationship ,Drug Delivery Systems ,In vivo ,Cell Line, Tumor ,Drug Discovery ,medicine ,Animals ,Humans ,drug carrier ,Doxorubicin ,Particle Size ,Lung cancer ,Original Research ,Cell Proliferation ,media_common ,Chemotherapy ,Drug Design, Development and Therapy ,Dose-Response Relationship, Drug ,Chemistry ,technology, industry, and agriculture ,Combination chemotherapy ,Enbucrilate ,medicine.disease ,PBCA ,lung cancer ,polymeric nanoparticles ,Nanoparticles ,Drug Screening Assays, Antitumor ,Drug carrier ,medicine.drug - Abstract
Consolación Melguizo1,2,* Laura Cabeza,1,* Jose Prados,1,2 Raúl Ortiz,1,3 Octavio Caba,1,3 Ana R Rama,1,3 Ángel V Delgado,4 José L Arias1,2,5 1Institute of Biopathology and Regenerative Medicine (IBIMER), Biomedical Research Center, 2Biosanitary Institute of Granada (IBS Granada), SAS Universidad de Granada, Granada, 3Department of Health Science, University of Jaén, Jaén, 4Department of Applied Physics, 5Department of Pharmacy and Pharmaceutical Technology, University of Granada, Granada, Spain *These authors contributed equally tothis work Abstract: Doxorubicin (Dox) is widely used for the combined chemotherapy of solid tumors. However, the use of these drug associations in lung cancer has low antitumor efficacy. To improve its efficacious delivery and activity in lung adenocarcinoma cells, we developed a biodegradable and noncytotoxic nanoplatform based on biodegradable poly(butylcyanoacrylate) (PBCA). The reproducible formulation method was based on an anionic polymerization process of the PBCA monomer, with the antitumor drug being entrapped within the nanoparticle (NP) matrix during its formation. Improved drug-entrapment efficiencies and sustained (biphasic) drug-release properties were made possible by taking advantage of the synthesis conditions (drug, monomer, and surfactant-agent concentrations). Dox-loaded NPs significantly enhanced cellular uptake of the drug in the A549 and LL/2 lung cancer cell lines, leading to a significant improvement of the drug’s antitumoral activity. In vivo studies demonstrated that Dox-loaded NPs clearly reduced tumor volumes and increased mouse-survival rates compared to the free drug. These results demonstrated that PBCA NPs may be used to optimize the antitumor activity of Dox, thus exhibiting a potential application in chemotherapy against lung adenocarcinoma. Keywords: lung cancer, cancer chemotherapy, PBCA, polymeric nanoparticles, drug carrier
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- 2015
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10. WITHDRAWN: 5-Fluorouracil-loaded iron/ethylcellulose (core/shell) nanoparticles for active targeting of cancer
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José L. Arias, Margarita López-Viota, Ángel V. Delgado, and M Adolfina Ruiz
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Pharmaceutical Science - Published
- 2009
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11. 5-Fluorouracil-loaded iron/ethylcellulose (core/shell) nanoparticles for active targeting of cancer
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Ángel V. Delgado, M. Adolfina Ruiz, Margarita López-Viota, and José L. Arias
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Drug ,Chemistry ,media_common.quotation_subject ,Pharmaceutical Science ,Nanoparticle ,Nanotechnology ,Controlled release ,Adsorption ,Targeted drug delivery ,Magnetic core ,Chemical engineering ,Drug delivery ,Nanomedicine ,media_common - Abstract
Even though 5-fluorouracil has been demonstrated to display antitumor activity against a wide variety of cancers, it is needed to be administered at high doses to elicit the required therapeutic activity, simultaneously leading to severe side effects. We hypothesized that the efficient delivery of 5-fluorouracil to tumors using a magnetic colloid could reduce the dose required to bring out sufficient therapeutic response. Thus, we have formulated a 5-fluorouracil-loaded magnetic nanomedicine consisting of a magnetic core (iron) and a biocompatible polymeric shell (ethylcellulose), suitable for parenteral administration. These core/shell nanoparticles were synthesized by an emulsion solvent evaporation process. Two drug loading methods were analyzed: the first one based on 5-fluorouracil surface adsorption onto the preformed nanoparticles, and the second method being drug addition prior to the emulsion solvent evaporation process leading to drug entrapment into the polymeric network. 5-Fluorouracil entrapment into the polymeric matrix yielded a higher drug loading and a slower drug release profile as compared with drug adsorption. Finally, as a proof of concept, Prussian blue staining has demonstrated the considerable accumulation of these magnetically guided composite nanoparticles in the tumors, suggesting the potential of this stimuli-sensitive drug carrier for the efficient treatment of cancer by active targeting.
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- 2009
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