1. Tumor stromal desmoplasia and inflammatory response uniquely predict survival with and without stratification for HPV tumor infection in OPSCC patients
- Author
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Hans Jørgen Aarstad, Hilde Haave, Stein Lybak, Jorunn Brekke, Sahil Gulati, and Olav Karsten Vintermyr
- Subjects
Adult ,Male ,0301 basic medicine ,Oncology ,medicine.medical_specialty ,Prognostic variable ,Stromal cell ,Inflammation ,Kaplan-Meier Estimate ,Disease-Free Survival ,Statistics, Nonparametric ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,Humans ,Medicine ,Survival analysis ,Aged ,Retrospective Studies ,Norway ,business.industry ,Proportional hazards model ,Biopsy, Needle ,Papillomavirus Infections ,General Medicine ,Middle Aged ,Prognosis ,Combined Modality Therapy ,Immunohistochemistry ,Survival Analysis ,Desmoplasia ,Oropharyngeal Neoplasms ,Tumor Virus Infections ,030104 developmental biology ,Otorhinolaryngology ,030220 oncology & carcinogenesis ,Cancer cell ,Carcinoma, Squamous Cell ,Female ,Mouth Neoplasms ,Histopathology ,medicine.symptom ,business - Abstract
Background Oropharyngeal squamous cell carcinoma (OPSCC) positive for human papillomavirus (HPV) increases wolrd wide. Aims/objectives The objective for this study has been to evaluate tumor phenotypes and tumor host responses with respect to five-year disease-specific survival (DSS) in HPV(+) and HPV(-) patients. Material and methods Two hundred patients with OPSCC have been treated between 1992 and 2010. Histopathology slides from these patients have been morphologically evaluated in formalin-fixed, paraffin-embedded (FFPE) stained with hematoxylin-eosin (HE). From HE-stained sections tumor phenotype (keratinization, fraction of mature cancer cells and pattern of invasion) and tumor host responses (inflammation and stromal desmoplasia) were evaluated with respect to five years DSS. Results High tumor inflammatory response and low stromal desmoplasia had an independent effect predicting better five-year DSS among all patients and when analyzed separately in the HPV(-) and HPV(+) cohort of patients using a Cox regression survival analysis that also included standard clinical prognostic variables among OPSCC patients. Conclusion Tumor host responses, inflammation and stromal desmoplasia may become part of routine work-up in OPSCC patients due to prognostic value. Significance We present a method, accessible in most clinical locations and would give important additional information about prognosis in OPSCC patients.
- Published
- 2018
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