1. Static magnetic field-enhanced osteogenic differentiation of human umbilical cord-derived mesenchymal stem cells via matrix vesicle secretion
- Author
-
Haw Ming Huang, Ching Yi Chang, Wei Zhen Lew, Sung Chih Hsieh, Hsin Hui Wang, Chung Lung Wu, and Sheng Wei Feng
- Subjects
medicine.medical_treatment ,Bone Morphogenetic Protein 2 ,Core Binding Factor Alpha 1 Subunit ,Matrix (biology) ,Umbilical cord ,Umbilical Cord ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Osteogenesis ,Wharton's jelly ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Secretion ,Radiological and Ultrasound Technology ,Chemistry ,Vesicle ,Mesenchymal stem cell ,food and beverages ,Cell Differentiation ,Mesenchymal Stem Cells ,Stem-cell therapy ,Alkaline Phosphatase ,Cell biology ,Magnetic Fields ,medicine.anatomical_structure ,030220 oncology & carcinogenesis - Abstract
In methodology, WJMSCs were treated with a 0.4-T SMF. The cell viability was tested using the MTT assay. For the osteogenic analysis, the alkaline phosphatase activity assay and alizarin red S staining were performed. The osteogenic-related gene expression ofThe cell viability showed no significant difference between the SMF-treated group and the sham-exposed cells. However, the SMF-treated group exhibited significantly more mineralized nodule formation and higher ALP activity than their control counterparts (The results suggest that 0.4-T SMF treatment enhances the osteogenesis of WJMSCs at the early-to-middle stage of osteogenic differentiation by increasing the matrix vesicle secretion and mineralization.
- Published
- 2020