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This review article is to explore the utilization of biodegradable polymers and their associated physicochemical properties in nano drug delivery (NDD). The main hub of the pharma industry is involved in the development of innovative biodegradable and biocompatible polymers which have targeting ability and a predictable release profile of an incorporated active pharmaceutical ingredient (API) or therapeutic agents. Moreover, the pharmaceutical and biological efficiency of the nano drug delivery system varies with the inherent properties of the polymer. The foremost, important physicochemical properties of biodegradable polymers include molecular weight, hydrophobicity, surface charge, crystallinity, composition of the co-polymer, glass transition temperature, and the nature of coating material. Nevertheless, these properties can be manipulated to modify the kinetics of the delivery system by selecting an optimum polymer (based on physicochemical properties) for a specific purpose.

A reversed phase high performance liquid chromatographic (RP-HPLC) method using Symmetry C18, 5.0-µm column was developed for simultaneous determination of Diclofenac diethylamine (DDEA) and Curcumin (CRM). Mobile phase consisted of orthophosphoric acid 0.1% and acetonitrile (65:35), and the flow rate was 1.5 mL/min and elution was monitored initially at 425 nm for CRM, after 14.7 min wavelength was changed to 275 nm for detection of DDEA. Response was a linear function of concentration over the range 0.245–1.96 µg/mL (R2 = 0.9998) for DDEA and 55–445 ng/mL (R2 = 0.9992) for CRM and the limits of detection were 245.5 ng/mL for DDEA and 55.30 ng/mL for CRM. The limit of quantitation was 491.1 ng mL − 1 for DDEA and 165.87 ng mL − 1 for CRM. The method was validated in accordance with ICH guidelines. The method was used for simultaneous quantification of DDEA and CRM in transdermal gel formulations and to check content uniformity. The excipients present in the formulation did not interfere with the assay. T...

A new UV-Spectrophotometric method has been described for the simultaneous assay of Diclofenac Diethylamine and Curcumin in transdermal gels using methanol as the solvent. The method is based on simultaneous equation or Vierodt’s method. The λmax values for Diclofenac Diethylamine and Curcumin in the solvent medium were found to be 275 nm and 425 nm respectively. The systems obey Beer’s law in the range of 2.0 to 22.0 μg/ml and 1.0 to 6.0μg/ml with correlation coefficient of 0.9994 and 0.9998 for Diclofenac Diethylamine and Curcumin respectively. Repeatability, Interday and intraday precision were found to be 1.61, 0.586, 0.662 and 0.371, 0.374, 0.410 respectively. Results of analysis have been validated statically and by recovery studies.