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Background: The aim of the study was to present metal health, psychosocial functioning and quality of life (QoL) of children and adolescents with a difference in sex development (DSD) from their first visit in the newly established multidisciplinary team in 2002–2004 in Norway. A secondary aim was to explore mental health, psychosocial functioning and QoL in the same cohort patient’s as for today and finally explore any childhood predictors for these outcomes in adulthood. Methods: The first part of the study took place in 2002–2004 in a mixed cohort of children and adolescents born with a DSD in 1982–2002, compared to a healthy comparison group. This part involved semi-structured interviews and self-reported and proxy-reported questionnaires. The second part of the study is a longitudinal study of the same participants 15–20 years later (2018–2020). Results: The participants at baseline of the study consisted of 33 patients; 24 assigned females (congenital adrenal hyperplasia, androgen insensitivity syndrome, gonadal dysgenesis and ovotesticular DSD) and nine assigned males; all with a hypospadias diagnosis. Significant differences were found for behavioral and emotional problems between groups, 46, XX females with significant higher total scores on YSR (49.43 + 24.17, p = .047); 46, XY females (21.00 + 12.04, p = .032); and higher internalizing problems scores (YSR) in 46, XX females (16.57 + 9.74), compared with the 46, XY females (5.60 + 5.32, p = .047). A positive association between QoL of the participants in adulthood and PedsQL’ social function (r = .657, p = .020) and psychosocial function in childhood (r = .596, p = .041) was found. Conclusions: In summary, this study demonstrated that adolescents assigned females with DSD might have more psychiatric problems and a poorer degree of psychosocial functioning compared to a healthy comparison group. As we do find an association with these problems in adolescence and later adult QoL, it is of great importance to respond to these behaviors in early life.

This study compared recently divorced Dane’s perceived stress scores with normative data of both (1) general and (2) divorced/separated populations, and investigated the predictive power of sociode...

Purpose To establish the validity of intracerebral hemorrhage (ICH) diagnoses in the Danish Stroke Registry (DSR) and the Danish National Patient Registry (DNPR). Patients and Methods Based on discharge summaries and brain imaging reports, we estimated the positive predictive value (PPV) of a first-ever diagnosis code for ICH (ICD-10, code I61) for all patients in the Region of Southern Denmark (1.2 million) during 2009-2017 according to either DNPR or DSR. We estimated PPVs for any non-traumatic ICH (a-ICH) and spontaneous ICH (s-ICH) alone (ie, without underlying structural cause). We also calculated the sensitivity of these diagnoses in each of the registers. Finally, we classified the location of verified s-ICH. Results A total of 3,956 patients with ICH diagnosis codes were studied (DSR only: 87; DNPR only: 1,513; both registries: 2,356). In the DSR, the PPVs were 86.5% (95% CI=85.1-87.8) for a-ICH and 81.8% (95% CI=80.2-83.3) for s-ICH. The PPVs in DNPR (discharge code, primary diagnostic position) were 76.2% (95% CI=74.7-77.6) for a-ICH and 70.2% (95% CI=68.6-71.8) for s-ICH. Sensitivity for a-ICH and s-ICH was 76.4% (95% CI=74.8-78.0) and 78.7% (95% CI=77.1-80.2) in DSR, and 87.3% (95% CI=86.0-88.5) and 87.7% (95% CI=86.3-88.9) in DNPR. The location of verified s-ICH was lobar (39%), deep (33.6%), infratentorial (13.2%), large unclassifiable (11%), isolated intraventricular (1.9%), or unclassifiable due to insufficient information (1.3%). Conclusion The validity of a-ICH diagnoses is high in both registries. For s-ICH, PPV was higher in DSR, while sensitivity was higher in DNPR. The location of s-ICH was similar to distributions seen in other populations.

Objectives: Surgical ablation is an established treatment for patients with atrial fibrillation undergoing cardiac surgery. This study aimed to compare postoperative rhythm outcomes and pacemaker implantation rates after biatrial ablation or pulmonary vein isolation (PVI) concomitantly with other cardiac surgery. Design: In a retrospective study, we included patients who underwent biatrial ablation or PVI. Postoperative rhythm status was assessed by Holter monitoring. All data on outcomes and patient characteristics were collected retrospectively. Results: In total 109 patients had a biatrial procedure whereas 337 had PVI performed. In patients with persistent/long-standing persistent atrial fibrillation, freedom from atrial fibrillation was more common after biatrial ablation than after PVI (63% and 45%, respectively; p =.039). Postoperative permanent pacemaker implantation was more common after biatrial ablation (12% and 6%, respectively; p =.039), compared to PVI. Age < 65 years (OR:2.0, 95% CI:1.1–3.6) was a predictor of freedom from atrial fibrillation in the biatrial group, whereas absence of left atrial dilatation (OR:1.8, 95% CI:1.1–3.2) and HAS-BLED score < 2 (OR:1.9, 95% CI:1.0–3.8) were significant predictors of freedom from atrial fibrillation in the PVI group. Conclusions: In patients with persistent/long-standing persistent atrial fibrillation, biatrial ablation is more effective than PVI in terms of obtaining freedom from postoperative atrial fibrillation. Although our groups were heterogenic in terms of concomitant surgery, our study also indicates that the risk of needing a permanent pacemaker is higher after biatrial ablation, compared to PVI. Therefore, our study highlights that the decision between biatrial ablation or PVI should be performed on an individual basis.

Background: In divorce research, studies using large samples, very recently divorced individuals and validated measures of depression and anxiety with available background populations for comparison are missing.Aims: This study aimed to investigate symptoms of depression and anxiety among recently divorced Danes and assess the explanatory power of relevant sociodemographic- and divorce-related variables on these symptoms.Methods: The study utilized an online cross-sectional design and a total of 1856 Danish citizens recruited through the Danish State Administration. Average scores for depression and anxiety were compared to the Danish background population and regression analyses were conducted to assess the explanatory power of sociodemographic- and divorce characteristics on symptoms of depression and anxiety.Results: Divorcees reported significantly higher levels of both depressive and anxiety symptoms than the background population with a large proportion of the sample scoring equal to or higher than generally recommended cut-off values for risk of suffering from a psychiatric diagnosable case of depression or anxiety. Both sociodemographic- and divorce characteristics were predictive of symptoms of depression and anxiety.Conclusion: The findings underline the relevance of public health intervention targeting symptoms of depression and anxiety among recently divorced individuals.

Jes S Lindholt, 1–3 Axel C Diederichsen, 2, 4 Lars M Rasmussen, 2, 5 Lars Frost, 6, 7 Flemming H Steffensen, 8 Jess Lambrechtsen, 8 Grazina Urbonaviciene, 6, 7 Martin Busk, 9 Kenneth Egstrup, 8 Katrine L Kristensen, 1–3 Carsten Behr Andersen, 3 Rikke Søgaard 10 1Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark; 2Elitary Centre for Individualized Medicine in Arterial Diseases (CIMA), Odense, Denmark; 3Department of Vascular Surgery, Viborg Hospital, Viborg, Denmark; 4Department of Cardiology, Odense University Hospital, Odense, Denmark; 5Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark; 6Department of Cardiology, Diagnostic Centre, Regional Hospital Silkeborg, Silkeborg, Denmark; 7Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; 8Department of Cardiology, Vejle Hospital, Vejle, Denmark; 9Department of Cardiology, University Hospital Odense Svendborg, Svendborg, Denmark; 10Department of Public Health and Department of Clinical Medicine, Aarhus University, Aarhus, DenmarkCorrespondence: Jes S LindholtDepartment of Cardiothoracic and Vascular Surgery, Odense University Hospital, J.B. Winsløv Vej 4, Odense 5000, DenmarkTel +45 2464 1214Email Jes.sanddal.lindholt@rsyd.dkAim: The prevalence and mortality of abdominal aortic aneurysms (AAA) has been reported to decline. The aim of this study is to compare survival, prevalence, and repair rate of AAA in Denmark in the 1990s, the 2000s and the 2010s – and to examine any change in factors known to influence the prevalence.Methods: Baseline status and up to 5-year outcomes of 34,079 general population men aged 65– 74 were obtained from three RCTs; the Viborg study (1994– 1998, n=4,860), the Viborg Vascular (VIVA) trial (2008– 2011, n=18,748), and the Danish Cardiovascular (DANCAVAS) trial (2015– 2018, n=10,471). After the millennium (VIVA and DANCAVAS) men with AAA were further offered low dose aspirin and statins. Follow-up data were not available for the DANCAVAS trial yet.Results: Across the three decades, the AAA prevalence was 3.8% (Reference), 3.3% (p< 0.001) and 4.2% (p=0.882), the proportion of smokers were 62%, 42% and 34% (p< 0.001) amongst men with AAA, but AAA risk associations with smoking increased during the decades suggesting increased tobacco consumption of smokers. In addition, the proportions of attenders with ischemic heart disease or stroke increased significantly. The aneurysmal progression rate in the 1990s was 2.90 vs 2.98 mm/year in the 2000s (p=0.91). The need for preventive AAA repair increased insignificantly in the 2000s (Age adj. HR= 1.29, 95% C.I.: 0.95; 1.71, p=0.10), and mortality of men with screen-detected AAA was lower in the 2000s compared to the 1990s (Age-adj. HR= 0.28, 95% C.I.: 0.22; 0.36, p< 0.001).Conclusion: The Danish prevalence of AAA today compares to the nineties. Unchanged aneurysmal progression rates combined with improved survival of men at risk of AAA leave them in longer time to develop an AAA, be diagnosed and to need later aneurysmal repair or experience rupture.Clinical Trial Registrations: Viborg study: No possibility of registration in the nineties. VIVA: NCT00662480, URL: https://clinicaltrials.gov/show/NCT00662480, DANCAVAS: ISRCTN12157806, URL: http://www.isrctn.com/ISRCTN12157806.Keywords: abdominal aortic aneurysms, screening, prevalence, survival, progression, smoking

A total of 2,371 Danish residents participating in the Cooperation After Divorce randomized controlled trial study indicated the motives for their divorce. The most frequently given motives were lack of love/intimacy, communication problems, lack of sympathy/respect/trust, and growing apart. The least reported motives were violence, addiction, accident or illness, and personality. The results support global trends regarding an increased importance of emotional and psychological aspects of relationships. A factor analysis seeking to identify clusters in the motives did not yield statistically or theoretically strong results. This may indicate that experiences with and motives for divorce are heterogeneous and multifactorial.

The mutational landscape of the Philadelphia chromosome negative chronic myeloproliferative neoplasms (MPN) displays a high homogeneity as 70% of patients harbor the Januskinase-2 (JAK2)V617F-mutat...

There is a lack of validated short screening instruments specifically addressing conflict and cooperation post-relationship/marital dissolution. Accordingly, this study aims to validate the newly d...

Cells in the tumor microenvironment of Follicular lymphoma (FL) express checkpoint molecules such as programmed death ligands 1 and 2 (PD-L1 and PD-L2) and are suppressing anti-tumor immune activity. Stimulation of peripheral blood mononuclear cells (PBMC) with PD-L1 (IO103) or PD-L2 (IO120) peptides can activate specific T cells inducing anti-regulatory functions including cytotoxicity against PD-L1/PD-L2-expressing cells. In this study, we vaccinated eight FL patients with PD-L1 and PD-L2 peptides following treatment with standard chemotherapy. Patients experienced grade 1–2 injection site reaction (5/8) and mild flu-like symptoms (6/8). One patient experienced neutropenia and thrombocytopenia during pseudo-progression. Enzyme-linked immunospot detected vaccine-specific immune responses in PBMC from all patients, predominately toward PD-L1. The circulating immune composition was stable during treatment; however, we observed a reduction regulatory T cells, however, not significant. One patient achieved a complete remission during vaccination and two patients had pseudo-progression followed by long-term disease regression. Further examination of these early signs of clinical efficacy of the dual-epitope vaccine in a larger study is warranted.

One way that tumors evade immune destruction is through tumor and stromal cell expression of arginine-degrading enzyme arginase-2 (ARG2). Here we describe the existence of pro-inflammatory effector T-cells that recognize ARG2 and can directly target tumor and tumor-infiltrating cells. Using a library of 34 peptides covering the entire ARG2 sequence, we examined reactivity toward these peptides in peripheral blood mononuclear cells from cancer patients and healthy individuals. Interferon-γ ELISPOT revealed frequent immune responses against several of the peptides, indicating that ARG2–specific self-reactive T-cells are natural components of the human T-cell repertoire. Based on this, the most immunogenic ARG2 protein region was further characterized. By identifying conditions in the microenvironment that induce ARG2 expression in myeloid cells, we showed that ARG2-specific CD4T-cells isolated and expanded from a peripheral pool from a prostate cancer patient could recognize target cells in an ARG2-dependent manner. In the ‘cold’ in vivo tumor model Lewis lung carcinoma, we found that activation of ARG2-specific T-cells by vaccination significantly inhibited tumor growth. Immune-modulatory vaccines targeting ARG2 thus are a candidate strategy for cancer immunotherapy.

Aim: To investigate factors that predict partnered sexual activity in men and women aged 60–75 years from Norway, Denmark, Belgium, and Portugal. Methods: Cross-sectional study including national representative samples of people aged 60–75 years from Norway (676 men, 594 women), Denmark (530 men, 515 women), Belgium (318 men, 672 women), and Portugal (236 men, 273 women). Data were collected by means of anonymous questionnaires. Results: Generally, across countries, the two most important predictors of partnered sexual activity were positive attitudes toward ‘Sex for well-being’, and sexual problems in the partner. Other important predictors of partnered sexual activity included positive attitudes toward sexual changes due to aging, previous sexual activity, and relationship happiness. Conclusion: The sexual function of the partner and people’s own sexual attitudes were highly predictive of partnered sexual activity.

Vincent Offermanns,1 Ole Z Andersen,2 Michael Sillassen,2 Klaus P Almtoft,3 Inge H Andersen,3 Frank Kloss,4 Morten Foss2,5 1Department of Cranio-Maxillofacial and Oral Surgery, Medical University of Innsbruck, Innsbruck, Austria; 2Interdisciplinary Nanoscience Center (iNANO), Faculty of Science and Technology, Aarhus University, Aarhus, Denmark; 3Tribology Center, Danish Technological Institute, Aarhus, Denmark; 4Private Practice, Lienz, Austria; 5Department of Physics and Astronomy, Faculty of Science and Technology, Aarhus University, Aarhus, Denmark Purpose: Studies have shown that strontium-doped medical applications benefit bone metabolism leading to improved bone healing and osseointegration. Based on this knowledge, the aim of the study was to evaluate the performance of an implant surface, functionalized by a physical vapor deposition (PVD) coating (Ti-Sr-O), designed to yield predictable release of strontium. The Ti-Sr-O functionalized surface is compared to a routinely used, commercially available surface (SLActive™) with respect to bone-to-implant contact (BIC%) and new bone formation (BF%) in two defined regions of interest (ROI-I and ROI-II, respectively).Materials and methods: Ti-Sr-O functionalized, SLActive, and Grade 4 titanium implants were inserted in the femoral condyle of adult male New Zealand White rabbits. The PVD magnetron-sputtered Ti-Sr-O surface coating was characterized using scanning electron microscopy (SEM) for morphology and coating thickness. Strontium release and mechanical stability of the coating, under simulated insertion conditions, were evaluated. Furthermore, histomorphometrical BIC and BF were carried out 2 weeks after insertion.Results: Histomorphometry revealed increased bone formation of Ti-Sr-O with significant differences compared to SLActive and Grade 4 titanium in both regions of interest, ROI-I and ROI-II, at 0–250 µm and 250–500 µm distance from the implant surfaces. Analogous results of bone-to-implant contact were observed for the two modified surfaces. Conclusion: The results show that a nanopatterned Ti-Sr-O functionalized titanium surface, with sustained release of strontium, increases peri-implant bone volume and could potentially contribute to enhancement of bone anchorage of osseointegrated implants. Keywords: biofunctionalization, wettability, physical vapor deposition, bioactive, surface modification, bone&nbsp

The present work investigates the corrosion resistance of Ni and Ni2Al3 coated austenitic stainless steel (TP347H) tubes, which were exposed in a biomass-fired boiler with an outlet steam temperature of 540 °C for 6757 h. The Ni2Al3 coating was produced by electroplating Ni followed by low temperature pack cementation. After exposure, microstructural investigations were performed by light optical and electron microscopy (SEM-EDS). Electroplated Ni coatings were not protective in straw firing power plants and exhibited similar corrosion morphology as uncoated tubes. For Ni2Al3 coatings, the nickel aluminide layer was no longer adherent to the tube and was only found within the deposit. However, Ni2Al3 coatings had provided some protection compared to uncoated and Ni coated tubes. The formation of nickel chloride binds aggressive chlorine and slows down the active oxidation mechanism. In local areas, sulphidation corrosion attack of Ni was detected.

The effect of microstructure on KCl corrosion attack was studied using a specifically chosen modified AISI 310 austenitic steel in a 15% (v/v) H2O (g) + 5%(v/v) O2 (g) + N2 (g) (balance) atmosphere at 600°C for 168 h. The material was a targeted choice as it allows investigation of different microstructures i.e. as-received (without sigma phase) and heat-treated (29% σ-phase per area) microstructures. The corrosion attack was studied with light optical, scanning electron and transmission electron microscopy as well as X-ray diffraction. The heat-treated sample showed a corrosion attack that was 5 times higher than the as-received sample. In the heat-treated sample, the σ-phase was selectively attacked. At the corrosion front, chlorine (but not potassium) was detected in the selectively attacked σ- phase but not in the unattacked adjacent matrix. Therefore, the corrosion attack was propagated by preferential σ-phase attack by chlorine species.

Somatic mutations in exon 9 of the calreticulin gene (CALR) are found in the majority of the JAK2V617F-negative Philadelphia-negative myeloproliferative neoplasms (MPNs), essential thrombocythemia ...

Young peoples' need for sexual counselling is well documented, and both website and hotline based services have been established as means of health promotion in this field. Such measures are, however, rarely evaluated, so this article offers data from the world's presumably oldest sexuality helpline aimed at young people. With an observation time of two decades and a total of 42,325 questions asked, the study provides a unique glance into the sexual landscapes of Danish youth. It shows an overall male predominance among callers and reveals that the counselling themes change over time and differ between both age groups and genders. The article suggests that telephone counselling - although more resource demanding than on-line alternatives - provides a secure, anonymous and dialogue-based arena for discussing delicate sexual issues and therefore may constitute a viable supplement to web based media for young people with the need to talk rather than just chat.

With the aim to develop and test a reliable and valid measure of communicative competencies in music for use in acquired brain injury rehabilitation settings, the interpersonal music-communication competence scale (IMCCS) was constructed, adapted from the interpersonal communication competence scale. Fifteen participants with medium to severe acquired brain injury, one music therapist and two blinded raters were involved in testing the IMCCS-Participant, the IMCCS-Therapist and the IMCCS-Rater versions of the scale. Before and after 20 music therapy sessions, each participant performed four music-based improvisational exercises in 1:1 sessions with the therapist (dialogue with the therapist, follow the musical ideas of the therapist, maintain musical phrases while therapist intentionally interrupt/challenge, and free improvisation with the therapist). Immediately following these improvisations, the participants and therapist completed the IMCCS. Two blinded raters completed the IMCCS-Rater after viewing video recordings of the exercises. Results revealed that the IMCCS-Therapist has good internal consistency (α = .89), the IMCCS-Participant has excellent internal consistency (α = .93), and the IMCCS-Rater has excellent internal consistency (α = .90). The two raters’ scores correlated significantly (r(26) = .54 to .73, p < .004), and a Cohen’s kappa analysis indicated a good agreement (Kw = .60). In addition, the correlation between the IMCCS-Rater and IMCCS-Therapist scores was adequate (r = .64, p = .005). All scales have satisfactory internal consistency and inter-rater reliability. These findings suggest that the IMCCS is a reliable measure of interpersonal communication competencies in music for people with acquired brain injury. With the aim to develop and test a reliable and valid measure of communicative competencies in music for use in acquired brain injury rehabilitation settings, the interpersonal music-communication competence scale (IMCCS) was constructed, adapted from the interpersonal communication competence scale. Fifteen participants with medium to severe acquired brain injury, one music therapist and two blinded raters were involved in testing the IMCCS-Participant, the IMCCS-Therapist and the IMCCS-Rater versions of the scale. Before and after 20 music therapy sessions, each participant performed four music-based improvisational exercises in 1:1 sessions with the therapist (dialogue with the therapist, follow the musical ideas of the therapist, maintain musical phrases while therapist intentionally interrupt/challenge, and free improvisation with the therapist). Immediately following these improvisations, the participants and therapist completed the IMCCS. Two blinded raters completed the IMCCS-Rater after viewing video recordings of the exercises. Results revealed that the IMCCS-Therapist has good internal consistency (α = .89), the IMCCS-Participant has excellent internal consistency (α = .93), and the IMCCS-Rater has excellent internal consistency (α = .90). The two raters’ scores correlated significantly (r(26) = .54 to .73, p < .004), and a Cohen’s kappa analysis indicated a good agreement (Kw = .60). In addition, the correlation between the IMCCS-Rater and IMCCS-Therapist scores was adequate (r = .64, p = .005). All scales have satisfactory internal consistency and inter-rater reliability. These findings suggest that the IMCCS is a reliable measure of interpersonal communication competencies in music for people with acquired brain injury. Luk

Colorectal cancers associated with Lynch syndrome are characterized by defective mismatch repair, microsatellite instability, high mutation rates, and a highly immunogenic environment. These features define a subset of cancer with a favorable prognosis and high likelihood to respond to treatment with anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) drugs. With the aim to define immune-evasive mechanisms and a potential impact hereof in colorectal cancers from Lynch syndrome versus hereditary cases with retained mismatch repair function, we immunohistochemically and transcriptionally profiled 270 tumors. Lynch syndrome-associated tumors showed an overrepresentation of tumor-infiltrating CD3, CD8 and CD68 positive cells, loss of beta-2-microglobulin (B2M) and up-regulation of PD-L1 on tumor cells. The gene expression signature of Lynch syndrome tumors was characterized by upregulation of genes related to antigen processing and presentation, apoptosis, natural killer cell-mediated cytotoxicity, and T cell activation. Tumors with loss of B2M and up-regulation of PD-L1 showed distinctive immunogenic profiles. In summary, our data demonstrate a complex tumor-host interplay where B2M loss and PD-L1 up-regulation influence immunological pathways and clinical outcome in Lynch syndrome tumors. Immunological classification may thus aid in the preselection of colorectal cancers relevant for treatment with anti-PD-1/PD-L1 therapies.

There is a lack of long-term register-based follow-up studies of sex-reassigned individuals concerning mortality and psychiatric morbidity. Accordingly, the present study investigated both mortality and psychiatric morbidity using a sample of individuals with transsexualism which comprised 98% (n = 104) of all individuals in Denmark.(1) To investigate psychiatric morbidity before and after sex reassignment surgery (SRS) among Danish individuals who underwent SRS during the period of 1978-2010. (2) To investigate mortality among Danish individuals who underwent SRS during the period of 1978-2010.Psychiatric morbidity and mortality were identified by data from the Danish Psychiatric Central Research Register and the Cause of Death Register through a retrospective register study of 104 sex-reassigned individuals.Overall, 27.9% of the sample were registered with psychiatric morbidity before SRS and 22.1% after SRS (p = not significant). A total of 6.7% of the sample were registered with psychiatric morbidity both before and after SRS. Significantly more psychiatric diagnoses were found before SRS for those assigned as female at birth. Ten individuals were registered as deceased post-SRS with an average age of death of 53.5 years.No significant difference in psychiatric morbidity or mortality was found between male to female and female to male (FtM) save for the total number of psychiatric diagnoses where FtM held a significantly higher number of psychiatric diagnoses overall. Despite the over-representation of psychiatric diagnoses both pre- and post-SRS the study found that only a relatively limited number of individuals had received diagnoses both prior to and after SRS. This suggests that generally SRS may reduce psychological morbidity for some individuals while increasing it for others.

Previous research on exposure to different types of pornography has primarily relied on analyses of millions of search terms and histories or on user exposure patterns within a given time period rather than the self-reported frequency of consumption. Further, previous research has almost exclusively relied on theoretical or ad hoc overarching categorizations of different types of pornography, when investigating patterns of pornography exposure, rather than latent structure analyses of these exposure patterns. In contrast, using a large sample of 18- to 40-year-old heterosexual and nonheterosexual Croatian men and women, this study investigated the self-reported frequency of using 27 different types of pornography and statistically explored their latent structures. The results showed substantial differences in consumption patterns across gender and sexual orientation. However, latent structure analyses of the 27 different types of pornography assessed suggested that although several categories of consumption were gender and sexual orientation specific, common categories across the different types of pornography could be established. Based on this finding, a five-item scale was proposed to indicate the use of nonmainstream (paraphilic) pornographic content, as this type of pornography has often been targeted in previous research. To the best of our knowledge, no similar measurement tool has been proposed before.

Anxiety is the most prevalent psychiatric disturbance in childhood effecting typically 15-20% of all youth. It has been associated with attachment insecurity and reduced competence in peer relations. Prior work has been limited by including mainly White samples, relying on questionnaires, and applying a cross-sectional design. The present study addressed these limitations by considering how at-risk non-White youth (n = 34) responded to the Friends and Family Interview (FFI) in middle childhood and how this linked up with anxiety symptoms and an anxiety diagnosis three years later in early adolescence. Five dimensions of secure attachment, namely, (i) to mother, (ii) to father, (iii) coherence, (iv) developmental understanding, and (v) social competence and quality of contact with best friend in middle childhood, were found to correlate significantly (and negatively) with self-reported anxiety symptoms. Linear regression results showed independent influences of female gender, and (low) quality of best friend contact as the most efficient model predicting anxiety symptoms. Logistic regression results suggested a model that included female gender, low social competence, and immature developmental understanding as efficient predictors of an anxiety diagnosis, evident in only 18% of the sample. These results point to the usefulness of after-school programs for at-risk minority youth in promoting peer competence, developmental awareness, and minimizing anxiety difficulties.

Using a self-selected online sample of 448 Norwegian men who have sex with men (MSM) and a cross-sectional design, the present study investigated first-person effects of sexually explicit media (SEM) consumption on sexual knowledge, enjoyment of and interest in sex, attitudes towards sex and understanding of one’s sexual orientation. First-person effects refer to self-perceived and self-reported effects of SEM consumption as experienced by the consumer. In addition, the study examined and provided a thorough validation of the psychometric properties of the seven-item Pornography Consumption Effect Scale (PCES). The study found that 93% of MSM reported small-to-large positive effects from their SEM consumption on their sexual knowledge, enjoyment of and interest in sex, attitudes towards sex and understanding of their sexual orientation. Only 7% reported any negative effects from their SEM consumption on these outcomes. Furthermore, the psychometric properties of the revised version of the PCES were found ...

Self-perceived effects of pornography consumption were studied in a sample of university students in Indonesia—a conservative, Muslim majority country with strict anti-pornography laws. Using a cross-sectional design and a modified version of the Pornography Consumption Effect Scale (PCES), we assessed participants' reports of how pornography affected their sexual knowledge, attitude toward sex, sex life, perception of and attitude toward the opposite gender, and life in general. The area of attitude toward sex excepted, the study found that both men and women reported significantly larger positive than negative effects. Further, as compared to women, men reported significantly larger negative effects of their pornography consumption. For both genders, pornography-related variables were found to add significantly to the prediction of both positive and negative self-perceived effects of pornography consumption over and above a number of included control variables.