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1. Microwave‐Assisted One‐Pot Synthesis of 2‐(Substituted phenyl)‐1H‐benzimidazole Derivatives

Author

Gabriel Navarrete-Vázquez, Mariana Torres-Piedra, Omar Munoz‐Muniz, Héctor Torres-Gómez, Hugo Tlahuext, Hermenegilda Moreno-Diaz, Ismael León-Rivera, and Samuel Estrada-Soto

Subjects
Benzimidazole, chemistry.chemical_compound, chemistry, Reagent, Organic Chemistry, Microwave irradiation, One-pot synthesis, Organic chemistry, Microwave assisted
Abstract

A series of 2‐(substituted phenyl)‐1H‐benzimidazole derivatives with various 5‐and 6‐position substituents (‐H, ‐CH3, ‐CF3) were synthesized via microwave irradiation using a short synthetic route and Na2S2O5 as oxidant. This simple, fast, and efficient preparation of benzimidazole derivatives has been developed using readily available and inexpensive reagents (aldehydes and 1,2‐phenylenediamines) under solvent‐free conditions.

Published
2007
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