Background: Coronaviruses are a large group of viruses that are common throughout the community They are associated with mortality, hospitalization, substantial extra costs and lower patient’s quality of life Thus, this study aimed to assess the community’s knowledge of COVID-19 and associated factors in Mizan-Aman town, southwest Ethiopia Methods: Community-based cross-sectional study design was conducted among the community of Mizan-Aman from April 14 to May 14, 2020 A systematic sampling technique was used to collect data from selected households Data were entered into Epi data version 4 0 2 101 and then exported to SPSS version 24 0 for analysis To identify the predictors of knowledge of COVID-19, multiple backward logistic regression analysis was used To show the accuracy of data analysis, 95% CI was used, and statistical significance was considered at p