Asghar Aghamohammadi, Yasser Bagheri, Hassan Abolhassani, Seyed Alireza Mahdaviani, Mohammamd Nabavi, Afshin Shirkani, Reza Yazdani, Fereshte Salami, Gholamreza Azizi, Saba Fekrvand, Morteza Samadi, Sahar Shariati, Samaneh Delavari, and Sepideh Shahkarami
Common variable immunodeficiency (CVID) is a primary immunodeficiency disease with a heterogeneous genetic background. Lipopolysaccharide-responsive beige-like anchor (LRBA), as well as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), have important regulatory roles in the immune responses. Here, we have investigated the expression of LRBA and CTLA-4 proteins in CVID patients with at least one presentation of early-onset occurrence, autoimmunity, or enteropathy. In this study, 20 newly diagnosed CVID patients without infection only phenotype, and ten healthy individuals were enrolled. The expressions of LRBA and CTLA-4 proteins were assessed by western blotting and flow cytometry, respectively. The patients were divided into two groups of autoimmunity-positive (11 cases) and autoimmunity-negative (9 patients). LRBA and CTLA-4 expressions were significantly lower in autoimmune-positive patients than in healthy individuals (