1. Enlargement of the human adrenal zona fasciculata and chronic psychiatric illness – an autopsy-based study
- Author
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Niels Lynnerup, Jytte Banner, Christina Jacobsen, Martin Balslev Jørgensen, Johannes Rødbro Busch, and Sissel Banner Lundemose
- Subjects
Adult ,Male ,Hypothalamo-Hypophyseal System ,endocrine system ,Pediatrics ,medicine.medical_specialty ,Physiology ,Pituitary-Adrenal System ,Autopsy ,03 medical and health sciences ,Behavioral Neuroscience ,0302 clinical medicine ,Zona fasciculata ,medicine ,Animals ,Humans ,Endocrine and Autonomic Systems ,Adrenal gland ,business.industry ,Mental Disorders ,Body Weight ,Mental illness ,medicine.disease ,030227 psychiatry ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,medicine.anatomical_structure ,nervous system ,Chronic mental illness ,Chronic Disease ,Schizophrenia ,Life expectancy ,Female ,Zona Fasciculata ,business ,hormones, hormone substitutes, and hormone antagonists ,030217 neurology & neurosurgery - Abstract
Severe mental illness (SMI) is associated with a reduced life expectancy of up to 20 years. One possible contributor to this fact is dysregulation of the hypothalamus-pituitary-adrenal (HPA)-axis. Looking at the morphology of effector organs, such as the adrenal glands themselves, could reveal insights into organ function and response to possible HPA-dysregulation. This forensic autopsy-based study investigated if there were any morphological changes in adrenal glands between decedents who had previously been submitted to a psychiatric hospital with a diagnosis of schizophrenia (
- Published
- 2019
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