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The ability to generate appropriate defense responses is crucial for the survival of an organism exposed to pathogenesis-inducing insults. However, the mechanisms that allow tissues and organs to cope with such stresses are poorly understood. Here we show that caspase-3-knockout mice or caspase inhibitor-treated mice were defective in activating the antiapoptotic Akt kinase in response to various chemical and environmental stresses causing sunburns, cardiomyopathy, or colitis. Defective Akt activation in caspase-3-knockout mice was accompanied by increased cell death and impaired survival in some cases. Mice homozygous for a mutation in RasGAP that prevents its cleavage by caspase-3 exhibited a similar defect in Akt activation, leading to increased apoptosis in stressed organs, marked deterioration of their physiological functions, and stronger disease development. Our results provide evidence for the relevance of caspase-3 as a stress intensity sensor that controls cell fate by either initiating a RasGAP cleavage-dependent cell resistance program or a cell suicide response.

It is a peculiar paradox that the fall of "really existing socialism" in Europe evoked surprisingly few serious reflections on the historical fate of the communist Utopia. In my view insufficient advantage has been taken of the opportunity to survey the communist phenomenon as a whole, that is, from the perspective of the completed cycle of its history in "the first country of socialism." One may even say that interest in the ideological sources of the communist experiment in Russia has declined significantly. The predominant view explains the Russian Revolution and its tragic consequences in terms of the peculiarities of Russian history, Russian culture, and even the Russian mentality.1 An emphasis on the role played by the universal (and Western in origin) ideology of Marxist communism is very often regarded either simply as naivety or as a relic of the early period of the Cold War.

The following discussion of the situation in the Soviet Union as perceived by the author in two visits, in March‐April 1991 and September 1991, was not written in the vain hope of presenting an up‐to‐date account of the changing events there. Rather, it is an attempt to begin to identify elements of continuity as well as change in the transition to postcommunism, and to assess both what led to the attempted coup and its defeat and factors bearing on the postcommunist future.

The paper consists of five parts. Part I describes the situation on the eve of martial law. Its main conclusion says: The release of this enormous tension could be achieved only through free elections, but it was absolutely clear that such a solution, tantamount to the total surrender of Communism in Poland, would never be accepted by the Russians’. Part II describes the evolution of the system of ‘partocracy’ in Poland from the early 1950s to the late 1970s. This evolution consisted in the gradual de‐ideologization of the party and the consequent change in the basic principle of legitimation. In the beginning it legitimized its rule by the Marxist theory of historical progress, in later years this was replaced by invoking the objective interests of the nation in given historical conditions. A positive feature of this development was the de‐ideologization of many spheres of life; this, however, did not entail their de‐politicization, in the sense of replacing changing and arbitrary political comm...