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The present study was carried out to evaluate the effects of 1α,25-dihydroxyvitamin D3 (VD) on chromosomal aberrations induced by doxorubicin (DXR). Wistar rats were divided into eight experimental groups of five animals each. Control group animals were treated with i.p. distilled water. The animals in three VD groups were given only VD for 4, 6 or 8 weeks. In the DXR groups the animals were given only DXR. In the combination groups VD doses were given for 4, 6 or 8 weeks for each group and DXR was injected 24 h before sacrificing the rats. DXR (50 mg/100 g b.w.) was injected intraperitoneally and VD by gavage 3 μg/kg/day twice weekly. Animals treated with both VD and DXR showed a low frequency of chromosomal aberrations and abnormal metaphases when compared with animals treated with DXR alone (p 0.05) and lower than those in week 4 for the VD groups (p

We report here the synthesis of a chiral A-ring synthon for 1α, 25-dihydroxyvitamin D3 starting from d-mannitol by using the cyanohydrin cyclization methodology.

The therapeutic efficacy and local and systemic safety of 3μg/g calcitriol ointment twice daily was assessed in a randomized, double-blind, vehicle-controlled, left-right study for 6 weeks treating 29 patients with severe chronic psoriatic plaques. The calcitriol treatment appeared to be very effective in improving erythema, induration, scaling and global severity of psoriatic plaques. The difference in clinical efficacy between calcitriol and vehicle ointment was highly significant as early as 1 week after the start of treatment. After 6 weeks, clearance of psoriatic lesions was found in 48% of calcitriol-treated sides and in 7% of vehicle-treated sides. Skin biopsies of calcitriol-treated sides revealed a reduction in epidermal hyperplasia, normalization of the keratinization process and decreased inflammation of the psoriatic skin. Calcitriol ointment did not cause cutaneous or systemic adverse reactions and did not induce disturbances of calcium and phosphorus horneo-stasis. Twice daily 3 μg/g calcitr...