1. Synercid plus vancomycin for the treatment of severe methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococci infections: evaluation of 5 cases.
- Author
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Sgarabotto D, Cusinato R, Narne E, Scano F, Zignol M, Gambino A, Cattelan A, Meneghetti F, and Cadrobbi P
- Subjects
- Abdominal Abscess microbiology, Adult, Aged, Anti-Bacterial Agents therapeutic use, Drug Therapy, Combination adverse effects, Endocarditis microbiology, Female, Heart-Assist Devices adverse effects, Heart-Assist Devices microbiology, Humans, Male, Methicillin pharmacology, Microbial Sensitivity Tests, Middle Aged, Staphylococcus aureus enzymology, Vancomycin adverse effects, Virginiamycin adverse effects, Coagulase deficiency, Drug Therapy, Combination therapeutic use, Methicillin Resistance, Staphylococcal Infections drug therapy, Staphylococcus aureus drug effects, Vancomycin therapeutic use, Virginiamycin therapeutic use
- Abstract
Synercid (quinupristin/dalfopristin), the first semi-synthetic injectable streptogramin, is a promising alternative to glycopeptides against many Gram-positive multiresistant bacteria. Vancomycin is still considered an effective agent for the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections but therapeutic failures with glycopeptides have been observed, even for the treatment of infections caused by S. aureus strains sensitive to vancomycin. Synercid, in combination with a glycopeptide, may address this problem without causing significant side effects due to the different toxicity patterns of the 2 antimicrobials. This study reports our experience with the combination of Synercid and vancomycin in 5 patients with severe infection caused by MRSA or methicillin-resistant coagulase-negative Staphylococcus.
- Published
- 2002
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