1. Domperidone-induced increase in lower oesophageal sphincter pressure does not affect azygos blood flow in patients with cirrhosis.
- Author
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Braillon A, Capron-Chivrac D, Valla D, Lee SS, Capron JP, and Lebrec D
- Subjects
- Esophageal and Gastric Varices prevention & control, Esophagogastric Junction physiopathology, Gastrointestinal Hemorrhage prevention & control, Hemodynamics drug effects, Humans, Hypertension, Portal etiology, Liver Cirrhosis complications, Middle Aged, Pressure, Domperidone therapeutic use, Esophagogastric Junction drug effects, Liver Circulation drug effects, Liver Cirrhosis physiopathology
- Abstract
An increase in lower oesophageal sphincter pressure induced by domperidone has previously been reported to decrease superior portosystemic collateral flow in patients with portal hypertension owing to cirrhosis. Although a 10-mg intravenous dose of domperidone was effective in increasing lower oesophageal sphincter tone in a group of six patients with cirrhosis, the same dose failed to affect azygos blood flow in a matched group of six patients. The results do not support the hypothesis that an increase in lower oesophageal sphincter tone can decrease flow through oesophageal varices in patients with cirrhosis.
- Published
- 1986
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