1. Adherence to antiretroviral therapy thought package-refill among HIV+ persons at 'D. Cotugno' hospital, Naples, Italy
- Author
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Francesco Maria, Fusco, Nadia, Sangiovanni, Nunzia, Papa, Nunzia, Cuomo, Orsola, Tambaro, Valentina, Iodice, Vincenzo, Bruner, Maria Aurora, Carleo, Viviana, Rizzo, Giulia, Palmiero, Mariana, Di Lorenzo, Micaela, Spatarella, Rosaria, Viglietti, Vincenzo, Sangiovanni, and Vincenzo, Esposito
- Subjects
Microbiology (medical) ,Infectious Diseases ,Original Articles - Abstract
BACKGROUND: A gold-standard for the measurement of adherence to antiretroviral therapy (ART) is lacking. Aim of this study is to verify the feasibility of a package-refill-based measurement of ART at “D. Cotugno” hospital, Naples, Italy, and the factors associated to adherence. METHODS: In the period January 2018–August 2020, we calculated the package-refill as the ratio between ART-packages actually withdrawn, and the ART packages needed to regularly take ART. Adherence was associated, trough a univariate e multivariate logistic regression, to demographical, behavioural and clinical factors. RESULTS: 1140 HIV+ subjects were included. At univariate logistic regression inadequate package-refill-based adherence is associated with HIV-RNA higher than 50 copies/mmL (OR 3.77-IC95% 2.76–5.13) and with HIVRNA higher than 200 copies/mmL (OR 3.98-IC95% 2.69–5.90). Being not-Italian and Injective-drug-user are associated with low adherence, having HIV/AIDS for more than 8 years is associated with better adherence. CONCLUSIONS: Package-refill is a suitable method for measuring adherence and is associated with the condition of viral failure.
- Published
- 2022