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Your search keyword '"Mepartricin administration & dosage"' showing total 2 results
Start Over Descriptor "Mepartricin administration & dosage" Publisher il farmaco
2 results on '"Mepartricin administration & dosage"'

1. A soluble mepartricin complex (SPA-S-222) of potential oral and parenteral utility in fungal and protozoal infections.

Author

Bruzzese T, Bianchi C, Goi A, Racchelli L, and Recusani F

Subjects
Administration, Oral, Animals, Drug Synergism, Female, Injections, Intravenous, Mepartricin administration & dosage, Mepartricin analogs & derivatives, Mepartricin toxicity, Mice, Rabbits, Rats, Sodium Dodecyl Sulfate, Candidiasis, Vulvovaginal drug therapy, Mepartricin therapeutic use, Polyenes therapeutic use, Trichomonas Vaginitis drug therapy
Abstract

Acute toxicity and absorption data of a soluble complex of mepartricin with sodium laurylsulphate (SPA-S-222) active against C. albicans and T. vaginalis are reported. The results demonstrate an improved bioavailability with respect to the insoluble substance. Preliminary clinical trials proved the good tolerance of the substance and its effectiveness in oral treatment of vaginal trichomoniasis.

Published
1976

2. Mepartricin, a polyene active on both Trichomonas and Candida. Lack of mutagenic activity.

Author

Ruozi P and Siccardi AG

Subjects
Administration, Topical, Animals, Candida albicans drug effects, Cryptococcus neoformans drug effects, Female, Humans, Male, Mepartricin administration & dosage, Metronidazole pharmacology, Mice, Trichomonas vaginalis drug effects, Candida drug effects, Mepartricin pharmacology, Mutation drug effects, Polyenes pharmacology, Trichomonas drug effects
Abstract

Mepartricin, the methyl ester of partricin, is a new polyene antibiotic with antifungal and antiprotozoal activity. The antitrichomonas activity in vitro is comparable to that of metronidazole, the widely used drug recently demonstrated to possess mutagenic activity and thus to be used with caution in therapy. Clinical investigations have shown that mepartricin can be successfully used in the topic treatment of vaginal trichomoniasis and candidiasis. The mutagenic activity of mepartricin has been evaluated using the Ames' test and compared to that of metronidazole. No mutagenic activity was detected for mepartricin. The drug can thus be proposed as a safer and efficient alternative to metronidazole.

Published
1978

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