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Your search keyword '"De Carlo, R."' showing total 2 results
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2 results on '"De Carlo, R."'

1. Derivatives of 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2.] nonane with antiarrhythmic, local anesthetic and hypotensive activities. III.

Author

Mariani E, Bondavalli F, Schenone P, Ranise A, Marfella A, De Carlo R, Matera GM, and Maramo E

Subjects
Acetylcholine antagonists & inhibitors, Animals, Bridged Bicyclo Compounds pharmacology, Chemical Phenomena, Chemistry, Guinea Pigs, In Vitro Techniques, Mice, Rats, Urea chemical synthesis, Urea pharmacology, Anesthetics, Local chemical synthesis, Anti-Arrhythmia Agents chemical synthesis, Antihypertensive Agents chemical synthesis, Bridged Bicyclo Compounds chemical synthesis, Bridged-Ring Compounds chemical synthesis, Urea analogs & derivatives
Abstract

The synthesis of alkyl and aryl ureas (II) derived from 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2.]nonane (I), as well as hydrazides (V), (VI) and (VII) derived from 5,7,7-trimethyl-6-oxa-3-azabicyclo[3.2.2]-nonan-3-amine (IV), is described. A number of theses compounds showed strong hypotensive and bradycardic activities in rats, as well as weak infiltration anesthesia and antiarrhythmic activity in mice. Antiacetylcholine activity in vitro is also reported.

Published
1982

2. Isonicotinates, nicotinates and clofibrates of N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)--1,3,3-trimethylbicyclo [2.2.1]heptan-2-endo-amine with hypocholesterolemic and hypolipidemic activity.

Author

Bondavalli F, Bruno O, Schenone P, Vacca C, De Carlo R, and Marmo E

Subjects
Animals, Anticholesteremic Agents pharmacology, Chemical Phenomena, Chemistry, Cholesterol blood, Clofibrate chemical synthesis, Clofibrate pharmacology, Hypolipidemic Agents pharmacology, Isonicotinic Acids pharmacology, Lipids blood, Nicotinic Acids pharmacology, Rats, Spectrophotometry, Infrared, Triglycerides blood, Triglycerides metabolism, Anticholesteremic Agents chemical synthesis, Clofibrate analogs & derivatives, Hypolipidemic Agents chemical synthesis, Isonicotinic Acids chemical synthesis, Nicotinic Acids chemical synthesis
Abstract

The synthesis of isonicotinic, nicotinic and clofibric esters (III a, b, c) and (IV a, b, c) starting from N-methyl-N-(2-hydroxyethyl or 3-hydroxypropyl)-1,3,3-trimethylbicyclo [2.2.1] heptan-2-endo-amine is described. In general these esters showed a normolipemic activity in rats; in particular, the isonicotinic ester (IV a) showed a hypocholesterolemic activity higher than that of clofibric acid.

Published
1987
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