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This chapter addresses the increasing role of pharmacoinformatics in enhancing the pharmacoeconomics context of decision-making. Notably, the role of pharmacoeconomics—i.e. cost per QALY calculations—is growing rapidly for decisions on reimbursement of new drugs. These pharmacoeconomic analyses often involve complex mathematical computer models requiring specific informatics techniques such as probabilistic simulations, bootstrapping, and discrete-event approaches. Transparancy of these complex models is crucial for decision makers to accept the model and its results. The authors argue that Web technology, Web-based access to models, international transferability of analyses, and decision-support systems may help in this respect. In particular, to allow decision makers and researchers to directly interact with transferable economic models and adapt a model to their region, efficient solutions have to be found to disseminate technically complex models to decision makers and researchers outside of the original setting. One such solution is through the use of Web technology and other pharmacoinformatics’ techniques as explored in this chapter.