1. Laser-generated-focused ultrasound transducers for microbubble-mediated, dual-excitation sonothrombolysis
- Author
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Paul A. Dayton, Joseph M. Stavas, Wei-Yi Chang, Jinwook Kim, Brooks D. Lindsey, Xiaoning Jiang, and Xuming Dai
- Subjects
Materials science ,business.industry ,Acoustics ,Ultrasound ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Laser ,01 natural sciences ,Focused ultrasound ,law.invention ,Transducer ,law ,Cavitation ,0103 physical sciences ,Microbubbles ,Ultrasonic sensor ,0210 nano-technology ,business ,010301 acoustics ,Excitation - Abstract
A laser-generated-focused ultrasound (LGFU) transducer generates high-pressure (up to 20 MPa), high-frequency (>10 MHz) shock waves with a tight focal spot. In this work, we aim to demonstrate the feasibility of using LGFU transducers for sonothrombolysis in vitro. A carbon black LGFU transducer was designed, fabricated and characterized. The prototyped LGFU was applied with in-vitro thrombolysis tests involving microbubble contrast agent (MCA). A conventional piezo ultrasound transducer was used as a secondary excitation source to enhance the cavitation effect by dual-frequency excitation. The in vitro test results showed that microbubble-mediated LGFU treatment can yield the lytic rate of approximately 2 mg/min, suggesting that LGFU transducers may be useful in precision high lytic rate sonothrombolysis.
- Published
- 2016
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