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Skin cancer is developed due to abnormal cell growth. These cells are grown rapidly and destroy the normal skin cells. However, it's curable at an initial stage to reduce the patient's mortality rate. In this article, the method is proposed for localization, segmentation and classification of the skin lesion at an early stage. The proposed method contains three phases. In phase I, different types of the skin lesion are localized using tinyYOLOv2 model in which open neural network (ONNX) and squeeze Net model are used as a backbone. The features are extracted from depthconcat7 layer of squeeze Net and passed as an input to the tinyYOLOv2. The propose model accurately localize the affected part of the skin. In Phase II, 13-layer 3D-semantic segmentation model (01 input, 04 convolutional, 03 batch-normalization, 03 ReLU, softmax and pixel classification) is used for segmentation. In the proposed segmentation model, pixel classification layer is used for computing the overlap region between the segmented and ground truth images. Later in Phase III, extract deep features using ResNet-18 model and optimized features are selected using ant colony optimization (ACO) method. The optimized features vector is passed to the classifiers such as optimized (O)-SVM and O-NB. The proposed method is evaluated on the top MICCAI ISIC challenging 2017, 2018 and 2019 datasets. The proposed method accurately localized, segmented and classified the skin lesion at an early stage. Qatar University [IRCC-2020-009].