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In IVF treatment, the pregnancy rate of selective single embryo implantation can be improved by detection the concentration of embryo growth factors such as $\mathbf{IL} -1\beta$ and $\mathbf{TNF}-\alpha$ in embryo culture medium. In this study, we manufacture the high dielectric constant digital microfluidic chip and develop a Bead-based digital microfluidic immunoassay with low sample requirement, low limit of detection and rapid immunoassay. We establish the mouse $\mathbf{TNF} -\alpha$ calibration curve and the requirement of sample is 520 nL, limit of detection is 1.55 pg/mL and total immunoassay time is 27 min. We also establish the Human $\mathbf{IL} -\mathbf{1\beta}$ calibration curve and the requirement of sample is 520 nL, limit of detection is 0.0579 pg/mL and total immunoassay time is 21 min.

One of the challenges in IVF treatment is to improve the pregnancy rate of selective single embryo implantation. The concentration of IL-1β in embryo culture medium may help to predict pregnancy rate. Clinically, each embryo can only get small amount of sample size. However, the traditional immunoassay cannot detect biomarkers in such small sample sizes. Therefore, we combined immunoassay with the bead-based digital microfluidic chip. The chip has two advantages, low sample requirement and low detection limit. We established the mouse IL-1β calibration curve, confirm the Human Tubal Fluid (HTF) does not influence the test result and demonstrate that mouse IL-1β in clinical mouse embryo culture medium is positively correlate to cultured days. This device has a great potential for increasing IVF pregnancy rates.

From traditional manufacturing to integrated circuit technology, shaft components have been utilized in different kinds of industries. Therefore, torsion monitoring to maintain the precision of machines is an important task. However, in order to check the performance, the shaft component needs to be dismounted from working position and installed in an expensive testing system for further diagnoses, which is labor-consuming and inefficient. In this study, we proposed a passive, wireless smart LC sensing tag based on the developed LC technology produced by commercial aluminum foil lamination and fast slitting techniques. With this smart tag fixed on the shaft, the torque generated by the system can be monitored, since the resonance frequency, shifting accordingly to the change of torque, can be readable by RF coils' inducting. Therefore, the smart LC sensing tag can work wirelessly and passively without physically connecting to a battery or power module. The goal of this study is to monitor stress at least 0.0056e by using the portable antenna analyzer which has the resolution about 1.3113MHz/e. This technology has the great vision that applies to the shaft monitoring in vehicles or fabrication machines. Furthermore, it can be integrated into IOT application.

A novel approach which uses a multiple partial exposure method to fabricate a transparent structured superomniphobic surface with doubly re-entrant structures by using negative thick photoresist SU-8 as the material is proposed. By using gray-tone lithography, the doubly re-entrant structures can be formed only via a standard lithography process. The gray-tone lithography for fabricating the doubly re-entrant structures is achieved by depositing three appropriate thicknesses of Ti film on glass substrate that acts as the gray-tone mask. The proposed transparent surface with the doubly re-entrant structures successful suspend all the tested liquid even the completely wetting liquid, such as silicon oil with the surface tension of 20.9 mN/m. This approach provides a simple, flexible and low-cost solution for fabricating superomniphobic surface, and it also has the potential to integrate with either flexible or nonflexible substrate for different applications.

This paper presents the prototype of a new remote guiding device to find the accurate screw hole position for drilling and direction for locking in intramedullary nailing surgery. The device consists of three magnetic pins and an electrical conductive board. The three symmetrically placed magnetic pins can rotate freely and point to the permanent magnet inside the nail. The drilling position and screwing direction can be obtained by moving the device with those magnetic pins to align with the magnet in the nail. The alignment condition is indicated by a LED. When the device is not aligned with the magnet in the nail properly, either in position or direction, the pins then will contact with the board to trigger a light-emitting diode for alarming.

We report a novel approach for targeting screw-holes of an intramedullary nail in a long-bone fracture surgery. The approach utilizes the electromagnetic induction to avoid over exposure of radioactivity which is the critical issue in conventional X-ray-imaging targeting method. Based on the approach, we fabricate a targeting system. The targeting system consists of a c-shaped electromagnet, detecting-coil, guiding-mechanism, and measurement electronics. When a voltage is applied to the electromagnet, magnetic flux is generated in the air gap of the electromagnet and subsequently detected by the coil. When the flux is detected by the coil, a voltage response is induced in the coil. When a nail in a bone is scanned through the air gap of the electromagnet, the flux is influenced due to a discrepancy of the permeability between the location with and without the hole of the nail. The influenced flux induces different voltage response in the coil. Through analyzing the voltage response, we establish a criterion for targeting the holes. By the criterion, the experimental result shows the maximum error of targeting a hole with a diameter of 5 mm is less than 2.5 mm.