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Given a set of pin-vertices, an obstacle-avoiding rectilinear Steiner minimal tree (OARSMT) connects all the pin-vertices possibly through Steiner points using vertical and horizontal segments with the minimal wirelength and without intersecting any obstacle. To deal with multiple routing layers and preferred routing orientations, we consider the multilayer obstacle-avoiding rectilinear Steiner minimal tree (ML-OARSMT) problem and the obstacle-avoiding preferred direction Steiner tree (OAPD-ST) problem. First, we prove that the multilayer case is theoretically different from the 2D one, and propose a reduction to transform a multilayer instance into a 3D instance. Based on the reduction, we apply computational geometry techniques to develop an efficient algorithm, utilizing existing OARSMT heuristics, for the ML-OARSMT problem and the OAPD-ST problem. Furthermore, we develop an advanced Steiner point selection to avoid inferior Steiner points and to improve the solution quality. Experimental results show that our algorithm provides a solution with excellent quality and has a significant speed-up compared to previously known results. [ABSTRACT FROM PUBLISHER]

For the obstacle-avoiding rectilinear Steiner minimal tree (OARSMT) problem, we present a Steiner-point-based algorithm that achieves the best practical performance among existing heuristics. We first propose a new concept of Steiner point locations, creating a linear-space routing graph with satisfactory Steiner point candidates to resolve the bottleneck of most existing heuristics. Then, we propose a Steiner-point-based framework to yield a solution, which is close to the key to the handling of the OARSMT problem. Experimental results show that this algorithm achieves excellent solution quality and speed performance at the same time. We also extend the Steiner-point-based framework to the obstacle-avoiding preferred direction Steiner tree problem with a good performance. [ABSTRACT FROM PUBLISHER]

We use an optimization technique to accurately locate a distorted grid structure in a microarray image. By assuming that spot centers deviate smoothly from a checkerboard grid structure, we show that the process of gridding spot centers can be formulated as a constrained optimization problem. The constraint is equal to the variations of the transform parameter. We demonstrate the accuracy of our algorithm on two sets of microarray images. One set consists of some images from the Stanford Microarray Database; we compare our centers with those annotated in the Database. The other set consists of oligonucleotide images, and we compare our results with those obtained by GenePix Pro 5.0. Our experiments were performed completely automatically. [ABSTRACT FROM AUTHOR]

In this correspondence, we first point out an error in Jia's algorithm (1998) by a counterexample. Second, we provide a fix and make an improvement to the part of Dynamic-Join. Finally, we give an analysis and a correctness proof of our algorithm. [ABSTRACT FROM AUTHOR]