1. Meal Simulation Model of the Glucose-Insulin System.
- Author
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Man, Chiara Dalla, Rizza, Robert A., and Cobelli, Claudio
- Subjects
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SIMULATION methods & models , *TYPE 2 diabetes , *TREATMENT of diabetes , *GLUCOSE , *INSULIN , *INSULIN pumps , *CARBOHYDRATE intolerance , *MANAGEMENT information systems , *BIOLOGICAL transport - Abstract
A simulation model of the glucose-insulin system in the postprandial state can be useful in several circumstances, including testing of glucose sensors, insulin infusion algorithms and decision support systems for diabetes. Here, we present a new simulation model in normal humans that describes the physiological events that occur after a meal, by employing the quantitative knowledge that has become available in recent years. Model parameters were set to fit the mean data of a large normal subject database that underwent a triple tracer meal protocol which provided quasi-model-independent estimates of major glucose and insulin fluxes, e.g., meal rate of appearance, endogenous glucose production, utilization of glucose, insulin secretion. By decomposing the system into sub-systems, we have developed parametric models of each subsystem by using a forcing function strategy. Model results are shown in describing both a single meal and normal daily life (breakfast, lunch, dinner) in normal. The same strategy is also applied on a smaller database for extending the model to type 2 diabetes. [ABSTRACT FROM AUTHOR] more...
- Published
- 2007
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