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In recent years, a growing number of dynamic, double-blind and randomized trials for traditional Chinese medicine (TCM) have been designed with adaptive treatment regimens. The blind envelope or current randomization and trial supply management (RTSM) system have not met this requirement. Therefore, a more efficient platform for subject randomization and medicine dispensation was required. After we had done much research on dynamic TCM treatment trials’ protocols, a new RTSM was designed and developed, which is suitable for TCM clinical trial during randomizing the groups for subject and medicine allocation in China. In a recurrent tuberculosis study of TCM, this RTSM system was involved in the management of subjects and medicines. By this system, a suit of TCM formulas or placeboes were assigned to patients based on their TCM syndrome diagnosis results by investigators at different visit points. The new RTSM system was convenient to operate, reduced operational errors, enhanced the management efficiency, and improved the data quality.

The light extraction has an important effect on LED encapsulation to obtain a high efficiency. The influence of packaging structure on LED light extraction was investigated in TracePro. Four kinds of high-power LED packaging methods based on the structure and the character of flip chip were presented, flip chip on board (1 reflective-cup), flip chip to substrate (1 reflective-cup), flip chip on board (100 reflective-cups) and flip chip to substrate (100 reflective-cups). Flip chip on board was that the LED chip was directly bonded to the aluminum substrate, flip chip to substrate was the LED chip bonded to the Si-Substrate before bonded to the aluminum. Two different structures of aluminum substrate were analyzed, 1 substrate with only 1 reflective cup and 1 substrate with 100 reflective cups. The final result shows that the luminous efficiency of flip chip on board (100 reflective-cups) is 0.03% higher than flip chip to substrate (100 reflective-cups); luminous efficiency of flip chip on board (1 reflective-cup1) is 0.04% lower than flip chip to substrate(1 reflective-cup). Luminous efficiency of flip chip on board (100 reflective-cups) is 10% higher than flip chip on board(1 reflective-cups); luminous efficiency of flip chip to substrate (100 reflective-cups) is 6.3% higher than flip chip to substrate(1 reflective-cup).