1. Cost-effective Fabrication of Chitosan Microneedles for Transdermal Drug Delivery
- Author
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Sameer Sonkusale, Hojatollah Rezaei Nejad, Gita Kiaee, and Aydin Sadeqi
- Subjects
Fabrication ,Materials science ,Microinjections ,Polymers ,Nanotechnology ,02 engineering and technology ,Administration, Cutaneous ,010402 general chemistry ,Engraving ,01 natural sciences ,Chitosan ,chemistry.chemical_compound ,Drug Delivery Systems ,Transdermal ,chemistry.chemical_classification ,Laser engraving ,Polymer ,021001 nanoscience & nanotechnology ,Casting ,0104 chemical sciences ,chemistry ,Needles ,visual_art ,Drug delivery ,visual_art.visual_art_medium ,0210 nano-technology - Abstract
In this paper we present fabrication of hollow and solid chitosan microneedles using a recently proposed low-cost and cleanroom-free fabrication method called Cross-Over Lines (COL) laser engraving. COL engraving is achieved using a commercial CO 2 laser-cutter to create microneedle molds on acrylic sheet. PDMS is then casted on the acrylic sheet microneedle mold to create base PDMS microneedles which are then used to generate other polymeric needles. In this paper, we cast and cure chitosan solution on the base PDMS microneedles which easily detaches from PDMS needles on drying. The resulted microneedles are hollow chitosan microneedles. We also made solid microneedles by silanizing and casting PDMSon-PDMS microneedles. We report promising preliminary results on drug delivery using these hollow and solid chitosan microneedles.
- Published
- 2018