1. Determination of Diffusion Weighted Magnetic Resonance Imaging Based Biomarkers of Mild Cognitive Impairment in Parkinson’s Disease
- Author
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Dilek Betul Arslan, Hasmet Hanagasi, Tamer Demiralp, Ani Kicik, Emel Erdogdu, Başar Bilgiç, Aziz M. Uluğ, Hakan Gurvit, Gokce Hale Hatay, Esin Ozturk Isik, Sevim Cengiz, Zeynep Tufekcioglu, and Ozge Can Kaplan
- Subjects
0301 basic medicine ,Parkinson's disease ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Tract based spatial statistics ,medicine.disease ,Diffusion-Weighted Magnetic Resonance Imaging ,White matter ,03 medical and health sciences ,030104 developmental biology ,0302 clinical medicine ,medicine.anatomical_structure ,Fractional anisotropy ,medicine ,FMRIB Software Library ,Cognitive impairment ,Nuclear medicine ,business ,030217 neurology & neurosurgery - Abstract
This study aims to specify biomarkers of Parkinson's disease mild cognitive impairment (PD-MCI) based on fractional anisotropy (FA) and mean diffusivity (MD) maps obtained from diffusion weighted magnetic resonance imaging (DWMRI). T1 and diffusion weighted MR images collected from 27 cognitively normal Parkinson's disease (PD-CN), 32 mild cognitively impaired Parkinson's disease (PD-MCI), and 18 healthy control (HC) volunteers, at a clinical 3T MR scanner, were processed using FMRIB Software Library (FSL)'s toolboxes. Average regional values of FA and MD maps and tract based spatial statistics (TBSS) were utilized to define statistically significant differences between the participant subject groups.
- Published
- 2017
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