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In this paper, the action that lead to an efficiently Targeted Drug Delivery through the process of internalization is studied. Although one can expects that the probability to reach a target is, however in praxis this might not be clean in the sense that the surface of nanoparticles composed by ions exerts electrical interaction with charged electrically compounds around. The action to internalize the nanoparticle acquires relevance when one expects either electrical attraction or repulsion between nanoparticle and tumor or target tissue. This paper tries to model this through the concept of overlapping wave functions. The results would indicate that quantum numbers might be critic at the action of internalization.

Cardiac fibroblasts are widely represented in mammalian cardiac tissue. These cells are connected with cardiomyocytes by gap junctions and they have own changeable membrane potential, so that fibroblasts can influence cardiomyocyte electrical activity. This effect may be analyzed in mathematical models. Existing mathematical models of fibroblast-cardiomyocyte interaction allow anyone to study only electrical responses of the cardiomyocytes and fibroblasts to their electrical interaction. In our work we have considered the fibroblast influence on the cardiomyocytes mechanics. In numerical experiments we reveal significant changes in the cardiomyocyte action potential duration and force depending on the number of fibroblast connected with the cardiomyocyte.

Electrical interaction of Engine Cooling Fan (ECF) with Heat Exchanger would strongly influence the electromagnetic behavior, and hence the EMC test results. Motivation and Objective for extensive and exhaustive component-level Electro-Magnetic Compliance (EMC) tests relies on close correlation and harmony between the vehicle-level and component-level test results. In fact, comprehensive component-level tests are presumed to indicate that most stringent possible vehicle-level Electro-Magnetic Interference (EMI) scenario is exercised in order to relieve expensive vehicle-level tests. This paper examines a component-level test scenario for an ECF according to OEM approved EMC test-plan mandating non-conductive air-flow load, thus resulting in AM band (0.53 MHz – 1.7 MHz) radiated emission deviations. Radiated Emissions (RE) deviations root-cause studies and troubleshooting indicates Amplitude Modulated (AM) band radiated emission compliance would result when a grounded metallic heat-exchanger is used.

This paper demonstrates a modeling methodology for the die-to-package connectivity in a Flip-chip Ball Grid Array (FCBGA) so that the die and package are simulated separately instead of co-simulation of the FCBGA structure for saving a computational cost. In addition, a cost saving polynomial regression modeling method is proposed to find electrical behavior for huge and complex package structures. In addition, various types of patterns were simulated to investigate and evaluate electrical interactions between the die and package through C4 bumps.

In this paper a study of layered surface acoustic wave (SAW) devices based on a ZnO/XY LiNbO/sub 3/ structure is presented. A 3-dimensional finite-element (3D-FE) approach has been applied to simulate device performance. Particle displacement profiles in depth and beam steering are presented. Furthermore, electrical interaction of the device to a modeled gas interaction is investigated. A comparison with experimental results is used to illustrate the accuracy of the model.