1. Harmonic Analysis of Neuronal Membranes and Tissue Using SQUIDs.
- Author
-
Claycomb, James R., Tran, Quoc, Vajrala, Vijayanand, and Miller Jr., John H.
- Subjects
- *
HARMONIC analysis (Mathematics) , *SUPERCONDUCTING quantum interference devices , *ELECTRIC fields , *MAGNETOMETERS , *MAGNETIC fields , *FOURIER transform spectroscopy , *ELECTRODES ,EARTHWORM anatomy - Abstract
We report the nonlinear response of tissue and nerve fibers in the earthworm Lumbricus terrestris to sinusoidal electric field excitations. A High-Tc Superconducting Quantum Interference Device (SQUID) magnetometer detects the magnetic field generated by complex currents in the animal. SQUID signals are processed on a Fast Fourier Transform (FFT) spectrum analyser. Use of the SQUID eliminates low frequency polarization impedance and field distortion that would be present near pickup electrodes. Electrical 4-probe harmonic response measurements of the excised nerve fiber are then compared to the driven Hodgkin-Huxley active transport model. [ABSTRACT FROM AUTHOR]
- Published
- 2009
- Full Text
- View/download PDF