1. A novel algorithm for generating simulated genetic data based on K-medoids
- Author
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Chunguang Zhou, Jianan Wu, Xuefei Xia, You Zhou, Zhangxu Li, and Seng Zhang
- Subjects
Noise ,Channel (digital image) ,k-medoids ,Group method of data handling ,Computer science ,Population-based incremental learning ,Reliability (computer networking) ,Genetic algorithm ,Gene expression ,Genetic data ,Algorithm - Abstract
Genetic data is very important for biological research, but it is hard to be obtained by experiment. In this paper, we introduce an algorithm for generating simulated genetic data based on K-mediods. A concept of Cluster Channel is proposed in this algorithm and used to generate simulated data. The noise of origin data could be eliminated using the proposed method. The experimental results show reliability of simulated genetic data. SAM is used to analyze the simulated data and original data, and we get a conclusion that the simulated data can effectively validate differentially expressed gene detected algorithm.
- Published
- 2012
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