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A novel microfluidic analysis platform is demonstrated for the real-time monitoring of traumatic brain injury (TBI) patients in intensive care. The system uses an on-chip array of Complementary Metal-Oxide-Semiconductor (CMOS) sensors implemented in an unmodified process to perform ion imaging. Specificity to several ionic species is achieved by depositing ion-selective membranes at the surface of the chip. Image processing techniques on the sensing array data enable the visualisation of the pattern of neurochemical changes caused by the evolving injury.

This demonstration presents a portable and low-power ISFET platform, powered by a solar panel battery system. A 32x32 ISFET array is connected to the portable platform using a custom cartridge, which interface with a Raspberry Pi that controls biasing, configuration and data acquisition, while displaying the results on a touchscreen. Inspired by classic videogame consoles, we present a GUI for screening and diagnosis which provides an intuitive experience for non-expert users, ultimately offering an end-to-end system for ISFET-based Point-of-Care diagnosis.