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Fiber-optic radiation sensors have been developed to detect gamma-rays generated from radioisotopes. Recently, many studies on the Cerenkov radiation in optical fibers without scintillator materials have been conducted to experimentally investigate their response characteristics against gamma-rays. The purpose of this study is to develop a Monte Carlo-based computer program in order to simulate the Cerenkov-based Fiber-Optic Radiation Sensor and to investigate the response characteristics of the sensor. In the model, the gamma photon generates an electron by Compton scattering and then the electron with velocity greater than the phase velocity of light generates an optical photon by the Cerenkov principle. Finally, the energy spectrum and number of optical photons are evaluated. The computer program is used to simulate the sensors under an environment with Iridium-192 radioisotope. The simulation results exhibited good agreement with experimental results.