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Your search keyword '"Ai-Ling Li"' showing total 4 results
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4 results on '"Ai-Ling Li"'

1. Miniature neurotransmitter sensors featured with iridium oxide nanorods

Author

Hung Cao, Jung-Chih Chiao, Ai-Ling Li, Smitha Rao, Yuan Bo Peng, and Cuong Nguyen

Subjects
Materials science, Fabrication, Anodic Aluminum Oxide, Scanning electron microscope, Energy dispersive spectrometry, Electrode, Nanorod, Nanotechnology, Iridium oxide, Chemical bath deposition
Abstract

In this work, we reported fabrication of new miniature sensors utilizing iridium oxide (IrO2) nanorods to improve the surface area for sensing. These sensors could be implanted to record neurotransmitter signals in the mammalian central nervous system. The IrO2 nanorods were grown in an anodic aluminum oxide (AAO) nanotemplate using a chemical bath deposition method on the sensing area of the sensors. The nanorods with height of 200 nm and diameter of 80 100 nm as characterized by scanning electron microscope (SEM) were fabricated. Energy dispersive spectrometry (EDS) was used to verify the composition of the nanorods. In vitro experiments with dopamine demonstrated that the IrO2 nanorod-based micro- sensors with an electrode size of 50×100 µm 2 achieved a sensitivity of 18 pA/µM.

Published
2014

2. A wireless bladder volume monitoring system using a flexible capacitance-based sensor

Author

Jung-Chih Chiao, Yuan-Bo Peng, Hung Cao, Ai-Ling Li, Uday Tata, and Vaibhav Landge

Subjects
Surface micromachining, Base station, Materials science, business.industry, Electro-optical sensor, Capacitive sensing, Electrical engineering, Wearable computer, Wireless, business, Capacitance, Wireless sensor network
Abstract

A wireless sensor system has been prototyped to monitor bladder volume in a small animal. The capacitance-based sensor was laser-micromachined from a polyimide film to form an interdigitated finger structure, followed by a sputtering process to deposit aluminum thin film. The entire sensor was encapsulated with biocompatible and elastic polydimethylsiloxane (PDMS). A passive telemetry platform based on inductive coupling was realized to employ the sensor in vivo and a commercial wireless module was used for data communication in air. The entire system consists of a sensor implant, an external wearable unit and a base station. The system was tested with a small rodent model demonstrating the feasibility and identifying practical issues in implementation.

Published
2013

3. A wearable telemetric neural/EMG/ECoG activity acquisition platform for small freely moving animals

Author

Yuan Bo Peng, Jung-Chih Chiao, Yang Wang, Ai-Ling Li, Xiaofei Yang, and Chao Zuo

Subjects
Engineering, Telecommunication network reliability, medicine.diagnostic_test, business.industry, Real-time computing, medicine, Electronic engineering, Wireless, Systems design, Wearable computer, business, Electrocorticography
Abstract

The needs for in vivo wireless acquisition of bioelectric signals are emerging in various medical and research fields. Biopotentials span a wide range of amplitudes and frequencies making the system design requirement application-oriented. We have developed a versatile integrated wireless platform that can be used to record several types of bioelectrical signals such as electrocorticography (ECoG), electromyography (EMG) and neuronal spikes. This system can provide reliable communication in real time with sufficient data rates from objects to computers. The system has been successfully validated and demonstrated its functionality and performance in appropriate animal models.

Published
2012

4. An Integrated Flexible Implantable Micro-Probe for Sensing Neurotransmitters.

Author

Hung Cao, Ai-Ling Li, Nguyen, C. M., Yuan-Bo Peng, and Jung-Chih Chiao

Abstract

In this work, we have developed an integrated flexible implantable probe on a polyimide-film substrate for sensing neurotransmitters. The flexibility of the probe helps to prevent scar forming in tissues aiming for long-term in vivo monitoring. A micro Ag/AgCl reference electrode was integrated in the same probe with the Au/Cr or Pt/Cr working electrodes providing measurements without the need of a separate reference probe. Several electrode configurations have been considered and designed for implantation at various locations in the central nervous system. The prototype device for proof of principle was an enzyme-based electrochemical L-glutamate sensor using L-glutamate oxidase. A comparison between Au and Pt thin films was conducted by cyclic voltammetry to evaluate their performance as working electrodes. The L-glutamate oxidase was deposited on the working electrodes followed by a meta-Phenylenediamine electropolymerization process to improve the selectivity. The self-referencing technique was also utilized to enhance both the limit of detection and selectivity. The assembled sensors were calibrated and tested at various concentrations of L-glutamate with and without the presence of interfering molecules. The results showed good sensitivity and selectivity. In vivo animal tests were conducted to show the capability of detecting changes of electrochemical signals responding to graded peripheral somatosensory stimuli. [ABSTRACT FROM PUBLISHER]

Published
2012
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