1. Synthesis of linear, branched, and cyclic peptide chimera.
- Author
-
Mezö G and Hudecz F
- Subjects
- Amino Acid Sequence, Animals, Conotoxins chemical synthesis, Conotoxins chemistry, Conotoxins genetics, Herpesvirus 1, Human chemistry, Herpesvirus 1, Human genetics, Humans, Molecular Sequence Data, Peptides, Cyclic chemical synthesis, Peptides, Cyclic chemistry, Recombinant Fusion Proteins chemistry, Recombinant Fusion Proteins genetics, Tuftsin chemical synthesis, Tuftsin chemistry, Tuftsin genetics, Viral Envelope Proteins chemical synthesis, Viral Envelope Proteins chemistry, Viral Envelope Proteins genetics, Molecular Biology methods, Recombinant Fusion Proteins chemical synthesis
- Abstract
Chimeric peptides are unnatural constructs consisting of bioactive compounds from at least two different peptide(s) and/or protein(s) or two sequences from different parts of the same protein. Such multifunctional peptide combinations are prepared to enhance the biological activity or selectivity of their components. New biological effects can also be achieved with the chimera. In this chapter the synthesis of three different types of chimeric peptides will be described. In a linear chimera, two peptide epitopes from different parts of glycoprotein D (gD) of herpes simplex virus (HSV) are combined. A branched chimera, built from linear peptides, consists of tuftsin oligomers with immunostimulatory activity and an epitope peptide of HSV gD. The third compound is a cyclic chimeric molecule, where alpha-conotoxin GI as a host peptide is modified by the incorporation of a core epitope from HSV gD as a guest sequence.
- Published
- 2005
- Full Text
- View/download PDF