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Diet and nutrition are important in the promotion and maintenance of good health throughout the entire life. A common denominator playing a role in the prevention of both chronic diseases and infections and hence important for maintaining health is a good functioning immune system. The competence of the immune system is an excellent marker of proper nutrition status and health and several changes in immune functions have been related to longevity. Preservation of a functionally youthful immune system throughout the years, including ensuring adequate vitamin and mineral status, is the best way to preserve health throughout life and to gain longevity accompanied by good quality of life.