Search

Your search keyword '"Panidis, Dimitrios"' showing total 36 results
Start Over Author "Panidis, Dimitrios" Publisher humana press
36 results on '"Panidis, Dimitrios"'

5. Anti-Androgens

Author

Ünlühizarci, Kürşad, Keleştimur, Fahrettin, Conn, P. Michael, editor, Diamanti-Kandarakis, Evanthia, editor, Nestler, John E., editor, Panidis, Dimitrios, editor, and Pasquali, Renato, editor

Published
2007
Full Text
View/download PDF

9. Imaging Studies in Polycystic Ovary Syndrome

Author

Jonard, Sophie, Robert, Yann, Ardaens, Yves, Dewailly, Didier, Conn, P. Michael, editor, Diamanti-Kandarakis, Evanthia, editor, Nestler, John E., editor, Panidis, Dimitrios, editor, and Pasquali, Renato, editor

Published
2007
Full Text
View/download PDF

21. 'Secondary' Polycystic Ovary Syndrome

Author

Kaltsas, Gregory, Chrousos, George, Conn, P. Michael, editor, Diamanti-Kandarakis, Evanthia, editor, Nestler, John E., editor, Panidis, Dimitrios, editor, and Pasquali, Renato, editor

Published
2007
Full Text
View/download PDF

28. Surgery and Laser Diathermy

Author

Palomba, Stefano, Zullo, Fulvio, Diamanti-Kandarakis, Evanthia, Orio, Francesco, Jr, Conn, P. Michael, editor, Diamanti-Kandarakis, Evanthia, editor, Nestler, John E., editor, Panidis, Dimitrios, editor, and Pasquali, Renato, editor

Published
2007
Full Text
View/download PDF

29. Glucose Intolerance

Author

Toscano, Vincenzo, Conn, P. Michael, editor, Diamanti-Kandarakis, Evanthia, editor, Nestler, John E., editor, Panidis, Dimitrios, editor, and Pasquali, Renato, editor

Published
2007
Full Text
View/download PDF

30. Cardiovascular Disease and Inflammation

Author

Orio, Francesco, Jr., Diamanti-Kandarakis, Evanthia, Palomba, Stefano, Conn, P. Michael, editor, Diamanti-Kandarakis, Evanthia, editor, Nestler, John E., editor, Panidis, Dimitrios, editor, and Pasquali, Renato, editor

Published
2007
Full Text
View/download PDF

34. Prevalence and impact of hyperandrogenemia in 1,218 women with polycystic ovary syndrome.

Author

Livadas S, Pappas C, Karachalios A, Marinakis E, Tolia N, Drakou M, Kaldrymides P, Panidis D, and Diamanti-Kandarakis E

Subjects
Adult, Androgens blood, Body Mass Index, Cross-Sectional Studies, Female, Follicle Stimulating Hormone blood, Humans, Hyperandrogenism blood, Luteinizing Hormone blood, Polycystic Ovary Syndrome blood, Prevalence, Sex Hormone-Binding Globulin analysis, Young Adult, Hyperandrogenism epidemiology, Polycystic Ovary Syndrome epidemiology
Abstract

Hyperandrogenemia modifies phenotypic characteristics of women with polycystic ovary syndrome (PCOS). The aim of the present study is to evaluate (a) the prevalence of hyperandrogenemia in PCOS women (Rotterdam criteria) and (b) the impact of either the degree or the type of hyperandrogenemia on phenotype. Anthropometric, clinical, hormonal, metabolic and ultrasound characteristics of 1,218 women with PCOS were analyzed in this cross-sectional study. The prevalence of hyperandrogenemia was 58.8 %. Women with hyperandrogenemia had higher luteinizing hormone (LH), follicle-stimulating hormone (FSH), free androgen index, lower sex-hormone-binding globulin (SHBG) and fasting glucose levels compared to women with normal androgens (p < 0.001 for all comparisons; p = 0.001 for fasting glucose). Regarding the presence of isolated hyperandrogenemia, the group with only elevated testosterone levels was termed GT and an analogous categorization was made for dehydroepiandrosterone sulfate (GD) and androstenedione (Δ4) (GΔ4), respectively. GT, GD and GΔ4 comprised the 17.2, 7.6 and 4.1 % of total cohort, respectively. These groups differed significantly between them in LH, LH/FSH ratio, and SHBG (p < 0.001). Hyperandrogenemia is found in almost 60 % of women with PCOS (Rotterdam criteria), and it affects hormonal characteristics of these women such as LH and SHBG values. Regarding the impact of isolated hyperandrogenemia on PCOS characteristics, it appears that Δ4 and testosterone elevations are associated with increased LH levels.

Published
2014
Full Text
View/download PDF

35. Lifestyle intervention and anti-obesity therapies in the polycystic ovary syndrome: impact on metabolism and fertility.

Author

Panidis D, Tziomalos K, Papadakis E, Vosnakis C, Chatzis P, and Katsikis I

Subjects
Anti-Obesity Agents therapeutic use, Diet, Exercise, Female, Humans, Obesity complications, Obesity metabolism, Polycystic Ovary Syndrome complications, Polycystic Ovary Syndrome metabolism, Energy Metabolism physiology, Fertility physiology, Life Style, Obesity therapy, Polycystic Ovary Syndrome therapy
Abstract

Obesity is frequently present in patients with polycystic ovary syndrome (PCOS) and plays an important role in the pathogenesis of the metabolic, endocrine, and reproductive abnormalities associated with this syndrome. We aimed to summarize the effects of lifestyle changes and anti-obesity pharmacotherapy in patients with PCOS. We reviewed the literature regarding the effects of lifestyle changes and anti-obesity agents on the metabolic and endocrine abnormalities of PCOS. Lifestyle changes, including diet, exercise, and behavioral modification, appear to improve the metabolic and reproductive abnormalities of overweight and obese patients with PCOS. Therefore, lifestyle changes appear to represent the first-line management for all overweight and obese patients with PCOS. However, the optimal composition of diet and the optimal type of exercise in these patients are unknown. Anti-obesity agents that have been studied in PCOS include orlistat, sibutramine, and rimonabant. However, the latter two agents have been withdrawn from the market because of side effects. Long-term studies with orlistat in overweight and obese diabetic patients showed greater weight loss and metabolic and cardiovascular benefits than those achieved with lifestyle changes alone. However, there are limited data on the efficacy of orlistat in women with PCOS. In conclusion, lifestyle changes (diet, exercise and behavioral modification), particularly when combined with anti-obesity agents, exert beneficial effects on the endocrine abnormalities of obese patients with PCOS and improve metabolic parameters.

Published
2013
Full Text
View/download PDF

36. Age, body mass index, and serum level of DHEA-S can predict glucocorticoid receptor function in women with polycystic ovary syndrome.

Author

Macut D, Vojnović Milutinović D, Božić I, Matić G, Brkljačić J, Panidis D, Petakov M, Spanos N, Bjekić J, Stanojlović O, Petrović Milinković A, Radojičić Z, and Damjanović S

Subjects
Adult, Cholesterol blood, Dexamethasone metabolism, Female, Glucocorticoids metabolism, Humans, Hydrocortisone blood, Kinetics, Ligands, Receptors, Glucocorticoid blood, Regression Analysis, Young Adult, Aging, Body Mass Index, Dehydroepiandrosterone Sulfate blood, Leukocytes, Mononuclear metabolism, Polycystic Ovary Syndrome blood, Polycystic Ovary Syndrome metabolism, Receptors, Glucocorticoid metabolism
Abstract

Glucocorticoid receptor (GR) transduces the glucocorticoid (GC) signal that could lead to metabolic derangements depending on the tissue responsiveness to GC. We aimed to investigate possible causative relation of the GR functional properties in peripheral blood mononuclear cells of women with polycystic ovary syndrome (PCOS), with their clinical and biochemical characteristics. Thirty women with PCOS [mean age: 26.5 ± 5.1 years, mean body mass index (BMI) 24.5 ± 5 kg/m(2)], and thirty respective controls were analyzed for the number of GR sites per cell (B (max)), apparent equilibrium dissociation constant (K (d)), and binding potency (GR potency). A strong association between B (max) and K (d) (r = 0.70, P < 0.0001), and GR potency with age (r = 0.49, P = 0.009) was observed in PCOS women. The multiple regression analyses within the PCOS group revealed that independent predictors for K (d) were BMI, total cholesterol, and dehydroepiandrosterone-sulfate (DHEA-S) (r = 0.58, P = 0.038), while for GR potency (r = 0.687, P = 0.013) were age, BMI, DHEA-S, and basal cortisol concentration. The results suggest that PCOS pathophysiology may be related to alterations of a cross stalk between glucocorticoid signaling, age, and metabolic parameters. These findings should be further explored in studies on the role of GR in PCOS-related metabolic derangements.

Published
2010
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results