1. [Progress of research on the relationship between calcitonin gene-related peptide and RANK/RANKL/OPG system in the bone reconstruction].
- Author
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Wang S, Xu S, Shi Z, Wu J, Lei S, and Wang Y
- Subjects
- Bone Remodeling physiology, Calcitonin, Carrier Proteins, Glycoproteins, Membrane Glycoproteins, NF-kappa B physiology, Receptors, Cytoplasmic and Nuclear, Calcitonin Gene-Related Peptide physiology, Osteoprotegerin physiology, RANK Ligand physiology, Receptor Activator of Nuclear Factor-kappa B physiology
- Abstract
Objective: To summarize the research progress on the calcitonin gene-related peptide (CGRP) and receptor activator of nuclear factor κB (RANK)/receptor activator of nuclear factor κB ligand (RANKL)/osteoprotegerin (OPG) system during bone reconstruction to provide theoretical basis for further research on the prevention and treatment of bone-related diseases., Methods: The relevant research results at home and abroad in recent years were analyzed and summarized., Results: CGRP and RANK/RANKL/OPG system play important regulatory roles in the bone reconstruction., Conclusion: At present, the research on the mechanism of CGRP and RANK/RANKL/OPG system in bone reconstruction is insufficient. Therefore, it is necessary to study further on the process and interrelation of CGRP and RANK/RANKL/OPG system in bone reconstruction to confirm their mechanism, which will bring new ideas and methods for the treatment of bone related diseases in clinic.
- Published
- 2019
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