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[ES] Las ataxias hereditarias constituyen un grupo heterogéneo de trastornos del movimiento caracterizados principalmente por una afectación progresiva en la estabilidad de la marcha y la coordinación asociada a degeneración del cerebelo, pudiendo haber afectación del habla y de movimientos oculares. Según el tipo de herencia se clasifican en ADCAs ( Autosomal Dominant Cerebellar Ataxias ) and ARCAs ( Autosomal Recessive Cerebellar Ataxias ). Las SCAs ( Spinocerebellar Ataxias ) constituyen la forma más común de ADCAs. Hasta la fecha se han descrito más de 40 subtipos, siendo la más frecuente la SCA3. Sin embargo, la prevalencia en cada territorio varía debido a efectos fundadores, siendo la SCA36 la más representativa en Galicia (21,3%). Respecto a las ARCAs las más relevantes son la ataxia de Friedreich y las ataxias con apraxia oculomotora tipo 1 y 2. El diagnóstico es complejo, especialmente en ADCAs debido a solapamientos clínicos, y por su acusada heterogeneidad genética. Por ello es importante el diagnóstico genético que permite establecer un diagnóstico definitivo y certero. En el presente trabajo se incluye el estudio de la secuenciación de exomas (WES, Whole Exome Sequencing ) de tres familias con ataxia hereditaria (fATX-163, fATX-166 y fATX-167) que han resultado negativas para todas las pruebas genéticas realizadas con anterioridad. Los datos brutos del WES se filtraron y se seleccionaron siguiendo un protocolo propio, y se obtuvo una lista de variantes candidatas. Posteriormente, se realizó su validación mediante secuenciación Sanger, y en la familia fATX-167 se estudió la segregación de las mutaciones seleccionadas para determinar una posible asociación con el fenotipo clínico. La SCA36 es una ADCA producida por expansiones del hexanucleótido GGCCTG en el intrón 1 del gen NOP56. El objetivo principal fue el diseño y la optimización de un test genético eficaz para detectar alelos expandidos (patológicos) mediante RP-PCR ( Repeat-Primed PCR) y electrofo, [EN] Hereditary ataxias constitute a heterogeneous group of movement disorders mainly characterized by progressive impairment of gait stability and coordination associated with cerebellar degeneration, sometimes affecting the speech and eye movements. According to the type of inheritance, they can be classified in ADCAs ( Autosomal Dominant Cerebellar Ataxias ) and ARCAs ( Autosomal Recessive Cerebellar Ataxias ). SCAs ( Spinocerebellar Ataxias) are the most common forms of ADCAs. More than 40 subtypes have been described so far, being SCA3 the most frequent one. However, the prevalence varies among territories due to founder effects, being SCA36 the most representative in Galicia (21.3%). Regarding ARCAs, the most relevant ones are Friedreich s ataxia and ataxias with oculomotor apraxia types 1 and 2. Diagnosis is complex, especially when it comes to ADCAs due to clinical overlaps and high genetic heterogeneity. Therefore, genetic diagnosis is important to establish a definitive and accurate diagnosis. This project includes the study of the whole exome sequencing (WES) of three families with hereditary ataxia (fATX-163, fATX-166 and fATX-167) that were negative for the prior genetic tests performed. Raw data from WES were filtered and selected following a pipeline developed in the laboratory, and a list of candidate variants was obtained. Then, validation was performed through Sanger sequencing, and in family fATX-167 the selected mutations were investigated in order to determine their possible correlation with the clinical phenotype. SCA36 is an ADCA caused by hexanucleotide GGCCTG expansion in intron 1 of NOP56 gene. The main objective was to design and optimize an efficient genetic test to detect expanded alleles (pathologic) through RP-PCR ( Repeat-Primed PCR) and capillary electrophoresis. Furthermore, a screening was performed in a 52-patient cohort having hereditary ataxia without genetic diagnosis, including patients from families fATX-163, 166 and 167. Now

[EN] Higher education is incorporating Information and Communication Technology (ICT) at a fast rate for different purposes. Scientific papers include within the concept of Technology Enhanced Learning (TEL) the myriad applications of information and communication technology, e-resources, and pedagogical approaches to the development of education. TEL¿s specific application to higher education is especially relevant for countries under rapid development for providing quick and sustainable access to quality education (UN sustainable development goal 4). This paper presents the research results of an online pedagogical experience in collaborative academic research for analyzing good practice in TEL-supported higher education development. The results are obtained through a pilot implementation providing curated data on TEL competency¿s development of faculty skills and analysis of developing sustainable higher education degrees through TEL cooperation, for capacity building. Given the increased volume and complexity of the knowledge to be delivered, and the exponential growth of the need for skilled workers in emerging economies, online training is the most effective way of delivering a sustainable higher education. The results of the PETRA Erasmus+ capacity-building project provides evidence of a successful implementation of a TEL-supported methodology for collaborative faculty development focused on future online degrees built collaboratively and applied locally.

[EN] Higher education is incorporating Information and Communication Technology (ICT) at a fast rate for different purposes. Scientific papers include within the concept of Technology Enhanced Learning (TEL) the myriad applications of information and communication technology, e-resources, and pedagogical approaches to the development of education. TEL¿s specific application to higher education is especially relevant for countries under rapid development for providing quick and sustainable access to quality education (UN sustainable development goal 4). This paper presents the research results of an online pedagogical experience in collaborative academic research for analyzing good practice in TEL-supported higher education development. The results are obtained through a pilot implementation providing curated data on TEL competency¿s development of faculty skills and analysis of developing sustainable higher education degrees through TEL cooperation, for capacity building. Given the increased volume and complexity of the knowledge to be delivered, and the exponential growth of the need for skilled workers in emerging economies, online training is the most effective way of delivering a sustainable higher education. The results of the PETRA Erasmus+ capacity-building project provides evidence of a successful implementation of a TEL-supported methodology for collaborative faculty development focused on future online degrees built collaboratively and applied locally.

[EN] In order to solve the complex decision-making problems, there are many approaches and systems based on the fuzzy theory were proposed. In 1998, Smarandache introduced the concept of single-valued neutrosophic set as a complete development of fuzzy theory. In this paper, we research on the distance measure between single-valued neutrosophic sets based on the H-max measure of Ngan et al. [8]. The proposed measure is also a distance measure between picture fuzzy sets which was introduced by Cuong in 2013 [15]. Based on the proposed measure, an Adaptive Neuro Picture Fuzzy Inference System (ANPFIS) is built and applied to the decision making for the link states in interconnection networks. In experimental evaluation on the real datasets taken from the UPV (Universitat Politècnica de València) university, the performance of the proposed model is better than that of the related fuzzy methods.

[ES] Las ataxias hereditarias constituyen un grupo heterogéneo de trastornos del movimiento caracterizados principalmente por una afectación progresiva en la estabilidad de la marcha y la coordinación asociada a degeneración del cerebelo, pudiendo haber afectación del habla y de movimientos oculares. Según el tipo de herencia se clasifican en ADCAs ( Autosomal Dominant Cerebellar Ataxias ) and ARCAs ( Autosomal Recessive Cerebellar Ataxias ). Las SCAs ( Spinocerebellar Ataxias ) constituyen la forma más común de ADCAs. Hasta la fecha se han descrito más de 40 subtipos, siendo la más frecuente la SCA3. Sin embargo, la prevalencia en cada territorio varía debido a efectos fundadores, siendo la SCA36 la más representativa en Galicia (21,3%). Respecto a las ARCAs las más relevantes son la ataxia de Friedreich y las ataxias con apraxia oculomotora tipo 1 y 2. El diagnóstico es complejo, especialmente en ADCAs debido a solapamientos clínicos, y por su acusada heterogeneidad genética. Por ello es importante el diagnóstico genético que permite establecer un diagnóstico definitivo y certero. En el presente trabajo se incluye el estudio de la secuenciación de exomas (WES, Whole Exome Sequencing ) de tres familias con ataxia hereditaria (fATX-163, fATX-166 y fATX-167) que han resultado negativas para todas las pruebas genéticas realizadas con anterioridad. Los datos brutos del WES se filtraron y se seleccionaron siguiendo un protocolo propio, y se obtuvo una lista de variantes candidatas. Posteriormente, se realizó su validación mediante secuenciación Sanger, y en la familia fATX-167 se estudió la segregación de las mutaciones seleccionadas para determinar una posible asociación con el fenotipo clínico. La SCA36 es una ADCA producida por expansiones del hexanucleótido GGCCTG en el intrón 1 del gen NOP56. El objetivo principal fue el diseño y la optimización de un test genético eficaz para detectar alelos expandidos (patológicos) mediante RP-PCR ( Repeat-Primed PCR) y electrofo, [EN] Hereditary ataxias constitute a heterogeneous group of movement disorders mainly characterized by progressive impairment of gait stability and coordination associated with cerebellar degeneration, sometimes affecting the speech and eye movements. According to the type of inheritance, they can be classified in ADCAs ( Autosomal Dominant Cerebellar Ataxias ) and ARCAs ( Autosomal Recessive Cerebellar Ataxias ). SCAs ( Spinocerebellar Ataxias) are the most common forms of ADCAs. More than 40 subtypes have been described so far, being SCA3 the most frequent one. However, the prevalence varies among territories due to founder effects, being SCA36 the most representative in Galicia (21.3%). Regarding ARCAs, the most relevant ones are Friedreich s ataxia and ataxias with oculomotor apraxia types 1 and 2. Diagnosis is complex, especially when it comes to ADCAs due to clinical overlaps and high genetic heterogeneity. Therefore, genetic diagnosis is important to establish a definitive and accurate diagnosis. This project includes the study of the whole exome sequencing (WES) of three families with hereditary ataxia (fATX-163, fATX-166 and fATX-167) that were negative for the prior genetic tests performed. Raw data from WES were filtered and selected following a pipeline developed in the laboratory, and a list of candidate variants was obtained. Then, validation was performed through Sanger sequencing, and in family fATX-167 the selected mutations were investigated in order to determine their possible correlation with the clinical phenotype. SCA36 is an ADCA caused by hexanucleotide GGCCTG expansion in intron 1 of NOP56 gene. The main objective was to design and optimize an efficient genetic test to detect expanded alleles (pathologic) through RP-PCR ( Repeat-Primed PCR) and capillary electrophoresis. Furthermore, a screening was performed in a 52-patient cohort having hereditary ataxia without genetic diagnosis, including patients from families fATX-163, 166 and 167. Now

[ES] Las ataxias hereditarias constituyen un grupo heterogéneo de trastornos del movimiento caracterizados principalmente por una afectación progresiva en la estabilidad de la marcha y la coordinación asociada a degeneración del cerebelo, pudiendo haber afectación del habla y de movimientos oculares. Según el tipo de herencia se clasifican en ADCAs ( Autosomal Dominant Cerebellar Ataxias ) and ARCAs ( Autosomal Recessive Cerebellar Ataxias ). Las SCAs ( Spinocerebellar Ataxias ) constituyen la forma más común de ADCAs. Hasta la fecha se han descrito más de 40 subtipos, siendo la más frecuente la SCA3. Sin embargo, la prevalencia en cada territorio varía debido a efectos fundadores, siendo la SCA36 la más representativa en Galicia (21,3%). Respecto a las ARCAs las más relevantes son la ataxia de Friedreich y las ataxias con apraxia oculomotora tipo 1 y 2. El diagnóstico es complejo, especialmente en ADCAs debido a solapamientos clínicos, y por su acusada heterogeneidad genética. Por ello es importante el diagnóstico genético que permite establecer un diagnóstico definitivo y certero. En el presente trabajo se incluye el estudio de la secuenciación de exomas (WES, Whole Exome Sequencing ) de tres familias con ataxia hereditaria (fATX-163, fATX-166 y fATX-167) que han resultado negativas para todas las pruebas genéticas realizadas con anterioridad. Los datos brutos del WES se filtraron y se seleccionaron siguiendo un protocolo propio, y se obtuvo una lista de variantes candidatas. Posteriormente, se realizó su validación mediante secuenciación Sanger, y en la familia fATX-167 se estudió la segregación de las mutaciones seleccionadas para determinar una posible asociación con el fenotipo clínico. La SCA36 es una ADCA producida por expansiones del hexanucleótido GGCCTG en el intrón 1 del gen NOP56. El objetivo principal fue el diseño y la optimización de un test genético eficaz para detectar alelos expandidos (patológicos) mediante RP-PCR ( Repeat-Primed PCR) y electrofo, [EN] Hereditary ataxias constitute a heterogeneous group of movement disorders mainly characterized by progressive impairment of gait stability and coordination associated with cerebellar degeneration, sometimes affecting the speech and eye movements. According to the type of inheritance, they can be classified in ADCAs ( Autosomal Dominant Cerebellar Ataxias ) and ARCAs ( Autosomal Recessive Cerebellar Ataxias ). SCAs ( Spinocerebellar Ataxias) are the most common forms of ADCAs. More than 40 subtypes have been described so far, being SCA3 the most frequent one. However, the prevalence varies among territories due to founder effects, being SCA36 the most representative in Galicia (21.3%). Regarding ARCAs, the most relevant ones are Friedreich s ataxia and ataxias with oculomotor apraxia types 1 and 2. Diagnosis is complex, especially when it comes to ADCAs due to clinical overlaps and high genetic heterogeneity. Therefore, genetic diagnosis is important to establish a definitive and accurate diagnosis. This project includes the study of the whole exome sequencing (WES) of three families with hereditary ataxia (fATX-163, fATX-166 and fATX-167) that were negative for the prior genetic tests performed. Raw data from WES were filtered and selected following a pipeline developed in the laboratory, and a list of candidate variants was obtained. Then, validation was performed through Sanger sequencing, and in family fATX-167 the selected mutations were investigated in order to determine their possible correlation with the clinical phenotype. SCA36 is an ADCA caused by hexanucleotide GGCCTG expansion in intron 1 of NOP56 gene. The main objective was to design and optimize an efficient genetic test to detect expanded alleles (pathologic) through RP-PCR ( Repeat-Primed PCR) and capillary electrophoresis. Furthermore, a screening was performed in a 52-patient cohort having hereditary ataxia without genetic diagnosis, including patients from families fATX-163, 166 and 167. Now

[ES] Las ataxias hereditarias constituyen un grupo heterogéneo de trastornos del movimiento caracterizados principalmente por una afectación progresiva en la estabilidad de la marcha y la coordinación asociada a degeneración del cerebelo, pudiendo haber afectación del habla y de movimientos oculares. Según el tipo de herencia se clasifican en ADCAs ( Autosomal Dominant Cerebellar Ataxias ) and ARCAs ( Autosomal Recessive Cerebellar Ataxias ). Las SCAs ( Spinocerebellar Ataxias ) constituyen la forma más común de ADCAs. Hasta la fecha se han descrito más de 40 subtipos, siendo la más frecuente la SCA3. Sin embargo, la prevalencia en cada territorio varía debido a efectos fundadores, siendo la SCA36 la más representativa en Galicia (21,3%). Respecto a las ARCAs las más relevantes son la ataxia de Friedreich y las ataxias con apraxia oculomotora tipo 1 y 2. El diagnóstico es complejo, especialmente en ADCAs debido a solapamientos clínicos, y por su acusada heterogeneidad genética. Por ello es importante el diagnóstico genético que permite establecer un diagnóstico definitivo y certero. En el presente trabajo se incluye el estudio de la secuenciación de exomas (WES, Whole Exome Sequencing ) de tres familias con ataxia hereditaria (fATX-163, fATX-166 y fATX-167) que han resultado negativas para todas las pruebas genéticas realizadas con anterioridad. Los datos brutos del WES se filtraron y se seleccionaron siguiendo un protocolo propio, y se obtuvo una lista de variantes candidatas. Posteriormente, se realizó su validación mediante secuenciación Sanger, y en la familia fATX-167 se estudió la segregación de las mutaciones seleccionadas para determinar una posible asociación con el fenotipo clínico. La SCA36 es una ADCA producida por expansiones del hexanucleótido GGCCTG en el intrón 1 del gen NOP56. El objetivo principal fue el diseño y la optimización de un test genético eficaz para detectar alelos expandidos (patológicos) mediante RP-PCR ( Repeat-Primed PCR) y electrofo, [EN] Hereditary ataxias constitute a heterogeneous group of movement disorders mainly characterized by progressive impairment of gait stability and coordination associated with cerebellar degeneration, sometimes affecting the speech and eye movements. According to the type of inheritance, they can be classified in ADCAs ( Autosomal Dominant Cerebellar Ataxias ) and ARCAs ( Autosomal Recessive Cerebellar Ataxias ). SCAs ( Spinocerebellar Ataxias) are the most common forms of ADCAs. More than 40 subtypes have been described so far, being SCA3 the most frequent one. However, the prevalence varies among territories due to founder effects, being SCA36 the most representative in Galicia (21.3%). Regarding ARCAs, the most relevant ones are Friedreich s ataxia and ataxias with oculomotor apraxia types 1 and 2. Diagnosis is complex, especially when it comes to ADCAs due to clinical overlaps and high genetic heterogeneity. Therefore, genetic diagnosis is important to establish a definitive and accurate diagnosis. This project includes the study of the whole exome sequencing (WES) of three families with hereditary ataxia (fATX-163, fATX-166 and fATX-167) that were negative for the prior genetic tests performed. Raw data from WES were filtered and selected following a pipeline developed in the laboratory, and a list of candidate variants was obtained. Then, validation was performed through Sanger sequencing, and in family fATX-167 the selected mutations were investigated in order to determine their possible correlation with the clinical phenotype. SCA36 is an ADCA caused by hexanucleotide GGCCTG expansion in intron 1 of NOP56 gene. The main objective was to design and optimize an efficient genetic test to detect expanded alleles (pathologic) through RP-PCR ( Repeat-Primed PCR) and capillary electrophoresis. Furthermore, a screening was performed in a 52-patient cohort having hereditary ataxia without genetic diagnosis, including patients from families fATX-163, 166 and 167. Now

[EN] This paper presents a human-computer cooperation platform, which permits the coordination between the user and the tool to improve the development of real-time control applications (e.g., mobile robots). These applications have functional (robot objectives) and temporal requirements to accomplish (deadlines guarantee of tasks). The simulation tool has been designed in order to permit the testing and validation of these two requirements. To this end, the tool is composed of two independent simulators interconnected through a shared memory: the robot simulator (functional level) and the real-time task scheduler simulator (task execution level). Robotic applications can be defined with the robot simulator while the real-time scheduler simulator permits to analyze the schedulability of the robotic tasks. The real-time task simulator incorporates a flexible task model where the task temporal parameters (e.g., computation time) adapt to the requirements of the application (e.g., number of objects in scenes); thus, the use of the CPU is not overestimated. A key issue of the framework is the human-computer interface, which allows the monitoring of different parameters of the application: robot objectives, task schedule, robot speed, computation time, CPU utilization, deadline misses. The usefulness of the simulation tool is shown through different robotic navigation experiments. Finally, the simulation tool has been used to evaluate the proposed flexible model of tasks compared to a traditional fixed temporal parameters task model. Results show that the robot fulfills the objectives earlier, about 32% on average, and consumes on average about 15% less CPU to accomplish the objectives.

[EN] Future exascale computing systems will require energy and performance efficient interconnection networks to respond to the high data movement demands of new applications, such as those coming from big-data and artificial intelligence areas. The network structure plays a major role in the overall interconnect performance, for this reason torus is a common topology used in the current largest supercomputers. There are several proposals to improve energy efficiency of interconnection networks. However, few works combine both energy and performance, and sometimes they are treated as opposed issues. In this paper, we try to determine which torus network configuration offers the best performance/energy ratio when high-radix switches are used to build the interconnect system. The performance/energy evaluation has been performed by trace-driven simulation under realistic scenarios, where several mixes of scientific applications share a supercomputer system and are scheduled to be executed with the available resources at each moment.

[EN] In order to save energy in HPC interconnection networks, one usual proposal is to switch idle links into a low-power mode after a certain time without any transmission, as IEEE Energy Efficient Ethernet standard proposes. Extending the low-power mode mechanism, we propose POWer-Aware Routing (POWAR), a simple power-aware routing and selection function for fat-tree and torus networks. POWAR adapts the amount of network links that can be used, taking into account the network load, and obtaining great energy savings in the network (55%-65%) and the entire system (9%-10%) with negligible performance overhead.

[ES] Las ataxias cerebelosas son un grupo heterogéneo de enfermedades del sistema nervioso central de carácter progresivo debidas a un proceso degenerativo que afecta a sistemas neuronales selectivos del cerebelo y sus vías. Los síntomas motores incluyen pérdida del equilibrio y de la coordinación, marcha inestable, disartria y movimientos oculares anómalos. Las ataxias hereditarias se suelen clasificar en dos grupos principales: ADCAs (Autosomal Dominant Cerebellar Ataxias) y ARCAs (Autosomal Recessive Cerebellar Ataxias), si bien también existen las formas ligadas al X. La prevalencia global de las ADCAs se estima en 1-5/100.000 y de las ARCAs en 3/100.000. Las ADCAs más frecuentes son las SCAs (SpinoCerebellar Ataxias) y las formas ARCA más comunes son la ataxia de Friedreich y las ataxias con mutaciones en el gen SPG7. Tanto para un grupo como para otro de ataxias, se conocen más de 80 genes implicados y esta cifra sigue creciendo. La disponibilidad actual de técnicas de secuenciación de última generación (NGS, Next Generation Sequencing) facilita indudablemente la consecución de un diganóstico genético de una forma más rápida y eficaz. Bases genéticas de las ataxias. En el marco de un proyecto de mecenazgo (http://indacea.org/) hemos diseñado una nueva herramienta de diagnóstico molecular para ataxias y paraparesias espásticas (SPGs). Hemos diseñado un panel con tecnología SureSelectXT (Agilent) para MiSeq (Illumina), que comprende 363 genes asociados con estos grupos de trastornos (panel AtxSPG-365). Así, en el marco del presente trabajo fin de grado se han investigado 19 pacientes con ataxias, cuyos datos crudos se han filtrado de acuerdo con un pipeline de diseño propio para la priorización de variantes de interés. Éstas han sido posteriormente analizadas mediante análisis de segregación con el propósito de lograr evidencias que afiancen o descarten que realmente son mutaciones clínicas. Análisis de una mutación de splicing en ATM. En una paciente de nuestra, [EN] Cerebellar ataxias are a heterogeneous group of diseases of the central nervous system of progressive character, due to a degenerative process that affects to selective neuronal systems of the brain and its pathways. Motor symptoms include loss of balance and coordination, unsteady gait, derangement, and abnormal eye movements. Hereditary ataxias are usually classified into two main groups: ADCA (Autosomal Dominant Cerebellar Ataxias) and ARCA (Autosomal Recessive Cerebellar Ataxias), although there are also X-linked forms. The overall prevalence of ADCA is considered in 1- 5/100,000 and ARCAs in 3/100,000. The most frequent ADCAs are SCAs (SpinoCerebellar Ataxias) and the most common ARCA forms are Friedreich's ataxia and ataxias with mutations in the SPG7 gene. Both, for one group and another of ataxias, more than 80 genes are known and this numere continues to grow. The current availability of Next Generation Sequencing (NGS) undoubtedly facilitates the achievement of a genetic diagnosis in a faster and more efficient way. Genetic bases of ataxias. In the framework of a sponsorship project (http://indacea.org/) we have designed a new molecular diagnostic tool for ataxias and spastic paraparesies (SPGs). We designed a panel with SureSelectXT (Agilent) technology for MiSeq (Illumina), comprising 363 genes associated with these groups of disorders (AtxSPG-365 panel). Thus, in the framework of the present bachelor’s thesis, 19 patients with ataxias have been investigated. Their results have been filtered according to a design pipeline of our own for the prioritization of the variants of interest. These have been analyzed by segregation analysis with the purpose of obtaining evidences that reveal or discard that these are clinical mutations. Analysis of an ATM splicing mutation. In a patient from our clinical ataxia series, two intronic changes in the ATM gene (NM_000051.3) were identified by the AtxSPG-365 panel: c.2921+1G>A (rs587781558, intron 19) / c.1899-11C

[ES] Las ataxias cerebelosas son un grupo heterogéneo de enfermedades del sistema nervioso central de carácter progresivo debidas a un proceso degenerativo que afecta a sistemas neuronales selectivos del cerebelo y sus vías. Los síntomas motores incluyen pérdida del equilibrio y de la coordinación, marcha inestable, disartria y movimientos oculares anómalos. Las ataxias hereditarias se suelen clasificar en dos grupos principales: ADCAs (Autosomal Dominant Cerebellar Ataxias) y ARCAs (Autosomal Recessive Cerebellar Ataxias), si bien también existen las formas ligadas al X. La prevalencia global de las ADCAs se estima en 1-5/100.000 y de las ARCAs en 3/100.000. Las ADCAs más frecuentes son las SCAs (SpinoCerebellar Ataxias) y las formas ARCA más comunes son la ataxia de Friedreich y las ataxias con mutaciones en el gen SPG7. Tanto para un grupo como para otro de ataxias, se conocen más de 80 genes implicados y esta cifra sigue creciendo. La disponibilidad actual de técnicas de secuenciación de última generación (NGS, Next Generation Sequencing) facilita indudablemente la consecución de un diganóstico genético de una forma más rápida y eficaz. Bases genéticas de las ataxias. En el marco de un proyecto de mecenazgo (http://indacea.org/) hemos diseñado una nueva herramienta de diagnóstico molecular para ataxias y paraparesias espásticas (SPGs). Hemos diseñado un panel con tecnología SureSelectXT (Agilent) para MiSeq (Illumina), que comprende 363 genes asociados con estos grupos de trastornos (panel AtxSPG-365). Así, en el marco del presente trabajo fin de grado se han investigado 19 pacientes con ataxias, cuyos datos crudos se han filtrado de acuerdo con un pipeline de diseño propio para la priorización de variantes de interés. Éstas han sido posteriormente analizadas mediante análisis de segregación con el propósito de lograr evidencias que afiancen o descarten que realmente son mutaciones clínicas. Análisis de una mutación de splicing en ATM. En una paciente de nuestra, [EN] Cerebellar ataxias are a heterogeneous group of diseases of the central nervous system of progressive character, due to a degenerative process that affects to selective neuronal systems of the brain and its pathways. Motor symptoms include loss of balance and coordination, unsteady gait, derangement, and abnormal eye movements. Hereditary ataxias are usually classified into two main groups: ADCA (Autosomal Dominant Cerebellar Ataxias) and ARCA (Autosomal Recessive Cerebellar Ataxias), although there are also X-linked forms. The overall prevalence of ADCA is considered in 1- 5/100,000 and ARCAs in 3/100,000. The most frequent ADCAs are SCAs (SpinoCerebellar Ataxias) and the most common ARCA forms are Friedreich's ataxia and ataxias with mutations in the SPG7 gene. Both, for one group and another of ataxias, more than 80 genes are known and this numere continues to grow. The current availability of Next Generation Sequencing (NGS) undoubtedly facilitates the achievement of a genetic diagnosis in a faster and more efficient way. Genetic bases of ataxias. In the framework of a sponsorship project (http://indacea.org/) we have designed a new molecular diagnostic tool for ataxias and spastic paraparesies (SPGs). We designed a panel with SureSelectXT (Agilent) technology for MiSeq (Illumina), comprising 363 genes associated with these groups of disorders (AtxSPG-365 panel). Thus, in the framework of the present bachelor’s thesis, 19 patients with ataxias have been investigated. Their results have been filtered according to a design pipeline of our own for the prioritization of the variants of interest. These have been analyzed by segregation analysis with the purpose of obtaining evidences that reveal or discard that these are clinical mutations. Analysis of an ATM splicing mutation. In a patient from our clinical ataxia series, two intronic changes in the ATM gene (NM_000051.3) were identified by the AtxSPG-365 panel: c.2921+1G>A (rs587781558, intron 19) / c.1899-11C

Tradicionalmente, el sector de la hostelería y, más específicamente, los negocios de restauración han sido menos proclives a su informatización que casi cualquier otro tipo de negocio. Sin embargo, esta tendencia ha comenzado a cambiar en los últimos años, en la medida que los negocios hosteleros han ido constatando cómo la automatización de alguno de sus procesos clave puede llevarles a mejorar de manera importante aspectos como sus tiempos de respuesta, sus costes operativos y la calidad del servicio al cliente. Así, el sector está actualmente inmerso en una re-industrialización basada en sistemas software. En este entorno, uno de los puntos que está atrayendo más atención es la comunicación entre los clientes de un restaurante y su centro de producción, que no es otro que su cocina. Este Trabajo Final de Máster se centra en el análisis, arquitectura y diseño de un Kitchen Display System (KDS), integrado en una solución preexistente de software de Terminal Punto de Venta (TPV). Los KDS son sistemas software capaces de comunicar a cocina todos los nuevos pedidos que se producen en un restaurante o negocio similar, permitiendo gestionarlos mediante una serie de acciones y primitivas preestablecidas. Estos sistemas también pueden enviar información del estado de los pedidos a los camareros y clientes en tiempo real. El análisis de requisitos del nuevo KDS se llevará a cabo atendiendo al estado del arte actual en este tipo de sistemas, así como al conocimiento del sector de uno de los fabricantes de software para hostelería líderes en el mercado español., Businesses within the hospitality sector and, most specifically, restaurant businesses, have traditionally been less prone to computerization than almost any other kind of enterprises. Nevertheless, this trend has started to change in recent years, as hospitality businesses are learning how automatization of some of their core processes can lead to improvements in response times, running costs and quality. Thus, the sector is currently in the middle of a computer-driven reindustrialization. One of the aspects that is attracting more attention in this environment is the communication between the client of a restaurant or similar business and its production center, i.e., its kitchen. This Master s Thesis will focus on the analysis, architecture and design of a Kitchen Display System (KDS) integrated into a previously existing Point Of Sale (POS) system. KDSs are pieces of software that are capable of communicating all the new orders to the kitchen of a restaurant, allowing to manage them with a number of actions. They may also send feedback to waiters or clients about each order status. The requirement analysis of the new KDS will be carried out by studying the current state of the art, and combining it with the know-how of a leading Spanish POS software company.

Tradicionalmente, el sector de la hostelería y, más específicamente, los negocios de restauración han sido menos proclives a su informatización que casi cualquier otro tipo de negocio. Sin embargo, esta tendencia ha comenzado a cambiar en los últimos años, en la medida que los negocios hosteleros han ido constatando cómo la automatización de alguno de sus procesos clave puede llevarles a mejorar de manera importante aspectos como sus tiempos de respuesta, sus costes operativos y la calidad del servicio al cliente. Así, el sector está actualmente inmerso en una re-industrialización basada en sistemas software. En este entorno, uno de los puntos que está atrayendo más atención es la comunicación entre los clientes de un restaurante y su centro de producción, que no es otro que su cocina. Este Trabajo Final de Máster se centra en el análisis, arquitectura y diseño de un Kitchen Display System (KDS), integrado en una solución preexistente de software de Terminal Punto de Venta (TPV). Los KDS son sistemas software capaces de comunicar a cocina todos los nuevos pedidos que se producen en un restaurante o negocio similar, permitiendo gestionarlos mediante una serie de acciones y primitivas preestablecidas. Estos sistemas también pueden enviar información del estado de los pedidos a los camareros y clientes en tiempo real. El análisis de requisitos del nuevo KDS se llevará a cabo atendiendo al estado del arte actual en este tipo de sistemas, así como al conocimiento del sector de uno de los fabricantes de software para hostelería líderes en el mercado español., Businesses within the hospitality sector and, most specifically, restaurant businesses, have traditionally been less prone to computerization than almost any other kind of enterprises. Nevertheless, this trend has started to change in recent years, as hospitality businesses are learning how automatization of some of their core processes can lead to improvements in response times, running costs and quality. Thus, the sector is currently in the middle of a computer-driven reindustrialization. One of the aspects that is attracting more attention in this environment is the communication between the client of a restaurant or similar business and its production center, i.e., its kitchen. This Master s Thesis will focus on the analysis, architecture and design of a Kitchen Display System (KDS) integrated into a previously existing Point Of Sale (POS) system. KDSs are pieces of software that are capable of communicating all the new orders to the kitchen of a restaurant, allowing to manage them with a number of actions. They may also send feedback to waiters or clients about each order status. The requirement analysis of the new KDS will be carried out by studying the current state of the art, and combining it with the know-how of a leading Spanish POS software company.

Tradicionalmente, el sector de la hostelería y, más específicamente, los negocios de restauración han sido menos proclives a su informatización que casi cualquier otro tipo de negocio. Sin embargo, esta tendencia ha comenzado a cambiar en los últimos años, en la medida que los negocios hosteleros han ido constatando cómo la automatización de alguno de sus procesos clave puede llevarles a mejorar de manera importante aspectos como sus tiempos de respuesta, sus costes operativos y la calidad del servicio al cliente. Así, el sector está actualmente inmerso en una re-industrialización basada en sistemas software. En este entorno, uno de los puntos que está atrayendo más atención es la comunicación entre los clientes de un restaurante y su centro de producción, que no es otro que su cocina. Este Trabajo Final de Máster se centra en el análisis, arquitectura y diseño de un Kitchen Display System (KDS), integrado en una solución preexistente de software de Terminal Punto de Venta (TPV). Los KDS son sistemas software capaces de comunicar a cocina todos los nuevos pedidos que se producen en un restaurante o negocio similar, permitiendo gestionarlos mediante una serie de acciones y primitivas preestablecidas. Estos sistemas también pueden enviar información del estado de los pedidos a los camareros y clientes en tiempo real. El análisis de requisitos del nuevo KDS se llevará a cabo atendiendo al estado del arte actual en este tipo de sistemas, así como al conocimiento del sector de uno de los fabricantes de software para hostelería líderes en el mercado español., Businesses within the hospitality sector and, most specifically, restaurant businesses, have traditionally been less prone to computerization than almost any other kind of enterprises. Nevertheless, this trend has started to change in recent years, as hospitality businesses are learning how automatization of some of their core processes can lead to improvements in response times, running costs and quality. Thus, the sector is currently in the middle of a computer-driven reindustrialization. One of the aspects that is attracting more attention in this environment is the communication between the client of a restaurant or similar business and its production center, i.e., its kitchen. This Master s Thesis will focus on the analysis, architecture and design of a Kitchen Display System (KDS) integrated into a previously existing Point Of Sale (POS) system. KDSs are pieces of software that are capable of communicating all the new orders to the kitchen of a restaurant, allowing to manage them with a number of actions. They may also send feedback to waiters or clients about each order status. The requirement analysis of the new KDS will be carried out by studying the current state of the art, and combining it with the know-how of a leading Spanish POS software company.

Tradicionalmente, el sector de la hostelería y, más específicamente, los negocios de restauración han sido menos proclives a su informatización que casi cualquier otro tipo de negocio. Sin embargo, esta tendencia ha comenzado a cambiar en los últimos años, en la medida que los negocios hosteleros han ido constatando cómo la automatización de alguno de sus procesos clave puede llevarles a mejorar de manera importante aspectos como sus tiempos de respuesta, sus costes operativos y la calidad del servicio al cliente. Así, el sector está actualmente inmerso en una re-industrialización basada en sistemas software. En este entorno, uno de los puntos que está atrayendo más atención es la comunicación entre los clientes de un restaurante y su centro de producción, que no es otro que su cocina. Este Trabajo Final de Máster se centra en el análisis, arquitectura y diseño de un Kitchen Display System (KDS), integrado en una solución preexistente de software de Terminal Punto de Venta (TPV). Los KDS son sistemas software capaces de comunicar a cocina todos los nuevos pedidos que se producen en un restaurante o negocio similar, permitiendo gestionarlos mediante una serie de acciones y primitivas preestablecidas. Estos sistemas también pueden enviar información del estado de los pedidos a los camareros y clientes en tiempo real. El análisis de requisitos del nuevo KDS se llevará a cabo atendiendo al estado del arte actual en este tipo de sistemas, así como al conocimiento del sector de uno de los fabricantes de software para hostelería líderes en el mercado español., Businesses within the hospitality sector and, most specifically, restaurant businesses, have traditionally been less prone to computerization than almost any other kind of enterprises. Nevertheless, this trend has started to change in recent years, as hospitality businesses are learning how automatization of some of their core processes can lead to improvements in response times, running costs and quality. Thus, the sector is currently in the middle of a computer-driven reindustrialization. One of the aspects that is attracting more attention in this environment is the communication between the client of a restaurant or similar business and its production center, i.e., its kitchen. This Master s Thesis will focus on the analysis, architecture and design of a Kitchen Display System (KDS) integrated into a previously existing Point Of Sale (POS) system. KDSs are pieces of software that are capable of communicating all the new orders to the kitchen of a restaurant, allowing to manage them with a number of actions. They may also send feedback to waiters or clients about each order status. The requirement analysis of the new KDS will be carried out by studying the current state of the art, and combining it with the know-how of a leading Spanish POS software company.

[ES] La enfermedad de Charcot-Marie-Tooth (CMT) o neuropatía sensitivo-motora here-ditaria (NSMH), es la neuropatía periférica hereditaria más común. Engloba un grupo de patologías clínica y genéticamente heterogéneas caracterizado por atrofia mus-cular, debilidad, y pérdida de la sensibilidad principalmente distal. El perfil genético y bioquímico de CMT solapa con el de otras neuropatías, complicando su diagnós-tico. Este Trabajo Final de Grado (TFG) tiene como objetivos: (i) lograr el diagnóstico molecular de una cohorte de pacientes con CMT en quienes previamente se han descartado mutaciones en genes implicados en CMT y otras neuropatías relaciona-das mediante panel de genes. Para ello, se secuenciará el exoma de estos pacientes y sus familiares con el propósito de identificar variantes genéticas candidatas a ser mutación causal. (ii) Investigar el posible efecto patológico de una mutación novel localizada en el gen MPZ (Myelin Protein Zero) mediante ensayos de localización subcelular., [EN] Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor and sensory neuropathy (HMSN), is the most common hereditary peripheral neuropathy. It en-compasses a clinically and genetically heterogeneous group of disorders character-ized by muscle wasting, weakness, and sensory loss usually most severe distally. The genetic and biochemical profile of CMT overlaps with that of other neuropathies, complicating diagnosis. This dissertation aims: (i) to obtain a molecular diagnosis for a cohort of CMT patients who have already undergone gene panel screening to rule out mutations related to CMT and other related neuropathies. The sequenced ex-ome data of patients and their relatives is studied in the search for gene variants with pathogenic potential. (ii) To study the possible pathogenic effect of a novel mu-tation on the gene MPZ (Myelin Protein Zero) via in vitro protein subcellular locali-zation assays.

[ES] La enfermedad de Charcot-Marie-Tooth (CMT) o neuropatía sensitivo-motora here-ditaria (NSMH), es la neuropatía periférica hereditaria más común. Engloba un grupo de patologías clínica y genéticamente heterogéneas caracterizado por atrofia mus-cular, debilidad, y pérdida de la sensibilidad principalmente distal. El perfil genético y bioquímico de CMT solapa con el de otras neuropatías, complicando su diagnós-tico. Este Trabajo Final de Grado (TFG) tiene como objetivos: (i) lograr el diagnóstico molecular de una cohorte de pacientes con CMT en quienes previamente se han descartado mutaciones en genes implicados en CMT y otras neuropatías relaciona-das mediante panel de genes. Para ello, se secuenciará el exoma de estos pacientes y sus familiares con el propósito de identificar variantes genéticas candidatas a ser mutación causal. (ii) Investigar el posible efecto patológico de una mutación novel localizada en el gen MPZ (Myelin Protein Zero) mediante ensayos de localización subcelular., [EN] Charcot-Marie-Tooth (CMT) disease, also known as hereditary motor and sensory neuropathy (HMSN), is the most common hereditary peripheral neuropathy. It en-compasses a clinically and genetically heterogeneous group of disorders character-ized by muscle wasting, weakness, and sensory loss usually most severe distally. The genetic and biochemical profile of CMT overlaps with that of other neuropathies, complicating diagnosis. This dissertation aims: (i) to obtain a molecular diagnosis for a cohort of CMT patients who have already undergone gene panel screening to rule out mutations related to CMT and other related neuropathies. The sequenced ex-ome data of patients and their relatives is studied in the search for gene variants with pathogenic potential. (ii) To study the possible pathogenic effect of a novel mu-tation on the gene MPZ (Myelin Protein Zero) via in vitro protein subcellular locali-zation assays.

[EN] The process of writing a report about the captured data and the graphic documentation is an essential part of the study and intervention in built heritage. This is not only due to the need for describing the architectural form, but also to accurately measure the geometry, size and, especially, the formal alterations which may affect the building. In this regard, the laser and digital photogrammetric technology used in the data capture process has the following benefits: • It is an essential source of information when it comes to assessing structural deformation and all the pathologies that affect the building structures, thanks to the accuracy and endless possibilities of digitally processing the captured data. • By digitally processing the information we can build solid digital models, which allow us to elaborate intervention proposals and operating theories. The project carried out in La Merced Church, Panama, complemented and provided graphic and geometric support to the study on characterization and strength of materials performed by the experts from AIDICO (Construction Technology Institute, Valencia, Spain) about the structural condition of the building. The work also describes the methodology used on the geometric data capture, the resolution of the difficulties encountered during the process, as well as the development of virtual models of the temple’s structure and historical façade, which are reference documents for planning the construction project., [ES] En el proceso de estudio e intervención en el patrimonio edificado, la captura de datos y la documentación gráfica a redactar constituye un aspecto decisivo no solo por la necesidad de describir la forma arquitectónica, sino por cuantificar con precisión su geometría, dimensión y, de manera especial, las alteraciones formales que afectan al edificio. En este sentido las tecnologías láser y de fotogrametría digital usada en el registro de datos: • Constituye una especial fuente de información a la hora de valorar las deformaciones estructurales y todas aquellas patologías formales que afectan las estructuras del edificio, dadas las precisiones y posibilidades de procesado digital de los datos capturados. • El procesado digital de la información obtenida hace posible la construcción de modelos digitales sólidos, a partir de los que elaborar propuestas de intervención e hipótesis de funcionamiento. El trabajo realizado sobre la iglesia de la Merced en Panamá, complementa y da soporte gráfico y geométrico a los ensayos de caracterización y resistencia de materiales realizados por los expertos de AIDICO sobre el estado estructural del edificio. El texto expone el proceso metodológico desarrollado, la satisfacción de las dificultades surgidas en el proceso, así como el desarrollo de construcciones virtuales del sistema estructural del templo y de su fachada histórica, como documentos de referencia en la elaboración del proyecto de intervención arquitectónica.

[EN] The process of writing a report about the captured data and the graphic documentation is an essential part of the study and intervention in built heritage. This is not only due to the need for describing the architectural form, but also to accurately measure the geometry, size and, especially, the formal alterations which may affect the building. In this regard, the laser and digital photogrammetric technology used in the data capture process has the following benefits: • It is an essential source of information when it comes to assessing structural deformation and all the pathologies that affect the building structures, thanks to the accuracy and endless possibilities of digitally processing the captured data. • By digitally processing the information we can build solid digital models, which allow us to elaborate intervention proposals and operating theories. The project carried out in La Merced Church, Panama, complemented and provided graphic and geometric support to the study on characterization and strength of materials performed by the experts from AIDICO (Construction Technology Institute, Valencia, Spain) about the structural condition of the building. The work also describes the methodology used on the geometric data capture, the resolution of the difficulties encountered during the process, as well as the development of virtual models of the temple’s structure and historical façade, which are reference documents for planning the construction project., [ES] En el proceso de estudio e intervención en el patrimonio edificado, la captura de datos y la documentación gráfica a redactar constituye un aspecto decisivo no solo por la necesidad de describir la forma arquitectónica, sino por cuantificar con precisión su geometría, dimensión y, de manera especial, las alteraciones formales que afectan al edificio. En este sentido las tecnologías láser y de fotogrametría digital usada en el registro de datos: • Constituye una especial fuente de información a la hora de valorar las deformaciones estructurales y todas aquellas patologías formales que afectan las estructuras del edificio, dadas las precisiones y posibilidades de procesado digital de los datos capturados. • El procesado digital de la información obtenida hace posible la construcción de modelos digitales sólidos, a partir de los que elaborar propuestas de intervención e hipótesis de funcionamiento. El trabajo realizado sobre la iglesia de la Merced en Panamá, complementa y da soporte gráfico y geométrico a los ensayos de caracterización y resistencia de materiales realizados por los expertos de AIDICO sobre el estado estructural del edificio. El texto expone el proceso metodológico desarrollado, la satisfacción de las dificultades surgidas en el proceso, así como el desarrollo de construcciones virtuales del sistema estructural del templo y de su fachada histórica, como documentos de referencia en la elaboración del proyecto de intervención arquitectónica.

[EN] The process of writing a report about the captured data and the graphic documentation is an essential part of the study and intervention in built heritage. This is not only due to the need for describing the architectural form, but also to accurately measure the geometry, size and, especially, the formal alterations which may affect the building. In this regard, the laser and digital photogrammetric technology used in the data capture process has the following benefits: • It is an essential source of information when it comes to assessing structural deformation and all the pathologies that affect the building structures, thanks to the accuracy and endless possibilities of digitally processing the captured data. • By digitally processing the information we can build solid digital models, which allow us to elaborate intervention proposals and operating theories. The project carried out in La Merced Church, Panama, complemented and provided graphic and geometric support to the study on characterization and strength of materials performed by the experts from AIDICO (Construction Technology Institute, Valencia, Spain) about the structural condition of the building. The work also describes the methodology used on the geometric data capture, the resolution of the difficulties encountered during the process, as well as the development of virtual models of the temple’s structure and historical façade, which are reference documents for planning the construction project., [ES] En el proceso de estudio e intervención en el patrimonio edificado, la captura de datos y la documentación gráfica a redactar constituye un aspecto decisivo no solo por la necesidad de describir la forma arquitectónica, sino por cuantificar con precisión su geometría, dimensión y, de manera especial, las alteraciones formales que afectan al edificio. En este sentido las tecnologías láser y de fotogrametría digital usada en el registro de datos: • Constituye una especial fuente de información a la hora de valorar las deformaciones estructurales y todas aquellas patologías formales que afectan las estructuras del edificio, dadas las precisiones y posibilidades de procesado digital de los datos capturados. • El procesado digital de la información obtenida hace posible la construcción de modelos digitales sólidos, a partir de los que elaborar propuestas de intervención e hipótesis de funcionamiento. El trabajo realizado sobre la iglesia de la Merced en Panamá, complementa y da soporte gráfico y geométrico a los ensayos de caracterización y resistencia de materiales realizados por los expertos de AIDICO sobre el estado estructural del edificio. El texto expone el proceso metodológico desarrollado, la satisfacción de las dificultades surgidas en el proceso, así como el desarrollo de construcciones virtuales del sistema estructural del templo y de su fachada histórica, como documentos de referencia en la elaboración del proyecto de intervención arquitectónica.

[EN] The process of writing a report about the captured data and the graphic documentation is an essential part of the study and intervention in built heritage. This is not only due to the need for describing the architectural form, but also to accurately measure the geometry, size and, especially, the formal alterations which may affect the building. In this regard, the laser and digital photogrammetric technology used in the data capture process has the following benefits: • It is an essential source of information when it comes to assessing structural deformation and all the pathologies that affect the building structures, thanks to the accuracy and endless possibilities of digitally processing the captured data. • By digitally processing the information we can build solid digital models, which allow us to elaborate intervention proposals and operating theories. The project carried out in La Merced Church, Panama, complemented and provided graphic and geometric support to the study on characterization and strength of materials performed by the experts from AIDICO (Construction Technology Institute, Valencia, Spain) about the structural condition of the building. The work also describes the methodology used on the geometric data capture, the resolution of the difficulties encountered during the process, as well as the development of virtual models of the temple’s structure and historical façade, which are reference documents for planning the construction project., [ES] En el proceso de estudio e intervención en el patrimonio edificado, la captura de datos y la documentación gráfica a redactar constituye un aspecto decisivo no solo por la necesidad de describir la forma arquitectónica, sino por cuantificar con precisión su geometría, dimensión y, de manera especial, las alteraciones formales que afectan al edificio. En este sentido las tecnologías láser y de fotogrametría digital usada en el registro de datos: • Constituye una especial fuente de información a la hora de valorar las deformaciones estructurales y todas aquellas patologías formales que afectan las estructuras del edificio, dadas las precisiones y posibilidades de procesado digital de los datos capturados. • El procesado digital de la información obtenida hace posible la construcción de modelos digitales sólidos, a partir de los que elaborar propuestas de intervención e hipótesis de funcionamiento. El trabajo realizado sobre la iglesia de la Merced en Panamá, complementa y da soporte gráfico y geométrico a los ensayos de caracterización y resistencia de materiales realizados por los expertos de AIDICO sobre el estado estructural del edificio. El texto expone el proceso metodológico desarrollado, la satisfacción de las dificultades surgidas en el proceso, así como el desarrollo de construcciones virtuales del sistema estructural del templo y de su fachada histórica, como documentos de referencia en la elaboración del proyecto de intervención arquitectónica.

[EN] The process of writing a report about the captured data and the graphic documentation is an essential part of the study and intervention in built heritage. This is not only due to the need for describing the architectural form, but also to accurately measure the geometry, size and, especially, the formal alterations which may affect the building. In this regard, the laser and digital photogrammetric technology used in the data capture process has the following benefits: • It is an essential source of information when it comes to assessing structural deformation and all the pathologies that affect the building structures, thanks to the accuracy and endless possibilities of digitally processing the captured data. • By digitally processing the information we can build solid digital models, which allow us to elaborate intervention proposals and operating theories. The project carried out in La Merced Church, Panama, complemented and provided graphic and geometric support to the study on characterization and strength of materials performed by the experts from AIDICO (Construction Technology Institute, Valencia, Spain) about the structural condition of the building. The work also describes the methodology used on the geometric data capture, the resolution of the difficulties encountered during the process, as well as the development of virtual models of the temple’s structure and historical façade, which are reference documents for planning the construction project., [ES] En el proceso de estudio e intervención en el patrimonio edificado, la captura de datos y la documentación gráfica a redactar constituye un aspecto decisivo no solo por la necesidad de describir la forma arquitectónica, sino por cuantificar con precisión su geometría, dimensión y, de manera especial, las alteraciones formales que afectan al edificio. En este sentido las tecnologías láser y de fotogrametría digital usada en el registro de datos: • Constituye una especial fuente de información a la hora de valorar las deformaciones estructurales y todas aquellas patologías formales que afectan las estructuras del edificio, dadas las precisiones y posibilidades de procesado digital de los datos capturados. • El procesado digital de la información obtenida hace posible la construcción de modelos digitales sólidos, a partir de los que elaborar propuestas de intervención e hipótesis de funcionamiento. El trabajo realizado sobre la iglesia de la Merced en Panamá, complementa y da soporte gráfico y geométrico a los ensayos de caracterización y resistencia de materiales realizados por los expertos de AIDICO sobre el estado estructural del edificio. El texto expone el proceso metodológico desarrollado, la satisfacción de las dificultades surgidas en el proceso, así como el desarrollo de construcciones virtuales del sistema estructural del templo y de su fachada histórica, como documentos de referencia en la elaboración del proyecto de intervención arquitectónica.

[EN] The process of writing a report about the captured data and the graphic documentation is an essential part of the study and intervention in built heritage. This is not only due to the need for describing the architectural form, but also to accurately measure the geometry, size and, especially, the formal alterations which may affect the building. In this regard, the laser and digital photogrammetric technology used in the data capture process has the following benefits: • It is an essential source of information when it comes to assessing structural deformation and all the pathologies that affect the building structures, thanks to the accuracy and endless possibilities of digitally processing the captured data. • By digitally processing the information we can build solid digital models, which allow us to elaborate intervention proposals and operating theories. The project carried out in La Merced Church, Panama, complemented and provided graphic and geometric support to the study on characterization and strength of materials performed by the experts from AIDICO (Construction Technology Institute, Valencia, Spain) about the structural condition of the building. The work also describes the methodology used on the geometric data capture, the resolution of the difficulties encountered during the process, as well as the development of virtual models of the temple’s structure and historical façade, which are reference documents for planning the construction project., [ES] En el proceso de estudio e intervención en el patrimonio edificado, la captura de datos y la documentación gráfica a redactar constituye un aspecto decisivo no solo por la necesidad de describir la forma arquitectónica, sino por cuantificar con precisión su geometría, dimensión y, de manera especial, las alteraciones formales que afectan al edificio. En este sentido las tecnologías láser y de fotogrametría digital usada en el registro de datos: • Constituye una especial fuente de información a la hora de valorar las deformaciones estructurales y todas aquellas patologías formales que afectan las estructuras del edificio, dadas las precisiones y posibilidades de procesado digital de los datos capturados. • El procesado digital de la información obtenida hace posible la construcción de modelos digitales sólidos, a partir de los que elaborar propuestas de intervención e hipótesis de funcionamiento. El trabajo realizado sobre la iglesia de la Merced en Panamá, complementa y da soporte gráfico y geométrico a los ensayos de caracterización y resistencia de materiales realizados por los expertos de AIDICO sobre el estado estructural del edificio. El texto expone el proceso metodológico desarrollado, la satisfacción de las dificultades surgidas en el proceso, así como el desarrollo de construcciones virtuales del sistema estructural del templo y de su fachada histórica, como documentos de referencia en la elaboración del proyecto de intervención arquitectónica.

Control architectures based on emotions are becoming promising solutions for the implementation of future robotic systems. The basic controllers of this architecture are the emotional processes that decide which behaviors the robot must activate to fulfill the objectives. The number of emotional processes increases (hundreds of millions/s) with the complexity level of the application, limiting the processing capacity of a main processor to solve the complex problems. Fortunately, the potential parallelism of emotional processes permits their execution in parallel, hence enabling the computing power to tackle the complex dynamic problems. In this paper, Graphic Processing Unit (GPU), multicore processors and single instruction multiple data (SIMD) instructions are used to provide parallelism for the emotional processes. Different GPUs, multicore processors and SIMD instruction sets are evaluated and compared to analyze their suitability to cope with robotic applications. The applications are set-up taking into account different environmental conditions, robot dynamics and emotional states. Experimental results show that, despite the fact that GPUs have a bottleneck in the data transmission between the host and the device, the evaluated GTX 670 GPU provides a performance of more than one order of magnitude greater than the initial implementation of the architecture on a single core. Thus, all complex proposed application problems can be solved using the GPU technology in contrast to the first prototype where only 55% of them could be solved. Using AVX SIMD instructions, the performance of the architecture is increased in 3.25 times in relation to the first implementation. Thus, from the 27 proposed applications about 88.8% are solved. In the case of the SSE SIMD instructions, the performance is almost doubled and the robot could solve about 74% of the proposed application problems. The use of AVX and SSE SIMD instructions provides almost the same performance as a quad

Control architectures based on emotions are becoming promising solutions for the implementation of future robotic systems. The basic controllers of this architecture are the emotional processes that decide which behaviors the robot must activate to fulfill the objectives. The number of emotional processes increases (hundreds of millions/s) with the complexity level of the application, limiting the processing capacity of a main processor to solve the complex problems. Fortunately, the potential parallelism of emotional processes permits their execution in parallel, hence enabling the computing power to tackle the complex dynamic problems. In this paper, Graphic Processing Unit (GPU), multicore processors and single instruction multiple data (SIMD) instructions are used to provide parallelism for the emotional processes. Different GPUs, multicore processors and SIMD instruction sets are evaluated and compared to analyze their suitability to cope with robotic applications. The applications are set-up taking into account different environmental conditions, robot dynamics and emotional states. Experimental results show that, despite the fact that GPUs have a bottleneck in the data transmission between the host and the device, the evaluated GTX 670 GPU provides a performance of more than one order of magnitude greater than the initial implementation of the architecture on a single core. Thus, all complex proposed application problems can be solved using the GPU technology in contrast to the first prototype where only 55% of them could be solved. Using AVX SIMD instructions, the performance of the architecture is increased in 3.25 times in relation to the first implementation. Thus, from the 27 proposed applications about 88.8% are solved. In the case of the SSE SIMD instructions, the performance is almost doubled and the robot could solve about 74% of the proposed application problems. The use of AVX and SSE SIMD instructions provides almost the same performance as a quad

[EN] To ensure the success of mobile learning, the use of an appropriate methodology to design and implement mobile device based on educational tools is a key issue. Industrial Computing (IC) subject is a third year compulsory subject of Industrial Electronic and Automation Engineering degree, which instructs students in the design and validation of Industrial Computing Systems (ICS) to control medium size industrial processes. IC is organized through a Problem Based Learning (PBL) methodology to carry out the implementation of ICS. In a traditional IC class, students had overheads to follow teacher's demonstrations. Students did not complete project implementation because they were unable to follow part of the explanations, and hence they get unmotivated. To solve this problem, an IC mobile device based multimedia teaching methodology, namely m-IC is developed. m-IC allows integration of lecture videos, problems, laboratories and development demonstrations of ICS projects. In this way, m-IC allows students autonomously plan their formation process and receive teacher guidance using a mobile phone. Moreover, smartphones availability makes these devices good candidates to learn IC. To show how students interact with m-IC, a smartphone application is detailed. The successful evaluation of m-IC by around 800 students during four years is presented.

This paper presents a multidisciplinary problem-based learning (PBL) project consisting of the development of a robot arm prototype and the implementation of its control system. The project is carried out as part of Industrial Informatics (II), a compulsory third-year course in the Automation and Electronic Engineering (AEE) degree program at the School of Engineering at Universitat Politècnica de València, València, Spain. The robot arm is a low-cost prototype, initially controlled with a joystick. The aim of the project is, first, to design and implement a full control system for the robot, including the necessary circuitry for microcomputer (ARM Cortex)-based control and, second, to pit the designed robot in competition against other students' robots. Incorporation of multidisciplinary PBL required changes in the organization of the course, which features various learning activities and their continuous evaluation; it also required knowledge of five other courses in the AEE program. PBL methodology is compared to a traditional method; the results obtained proved highly satisfactory. Moreover, the PBL robotic experience was highly rated by some 900 students.

NOTICE: this is the author’s version of a work that was accepted for publication in Parallel Computing. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Parallel Computing, [Volume 48, October 2015, Pages 59–80] DOI 10.1016/j.parco.2015.03.007, As higher communication bandwidth is required in current designs of high performance parallel computers, the amount of power consumed by the interconnection network also increases. Fat-tree is one of the most popular topologies in high performance interconnection networks aiming at low latency, efficient collective communication and scalability. We present a new methodology for managing power consumption of fat-tree interconnection networks. Our proposal is based on dynamically adjusting available network bandwidth according to traffic requirements. To meet this goal, we define a mechanism for managing the operating status of network links as a function of network load. Our main contributions include a complete definition of the mechanism and a tuning methodology based on its sensitivity and aggressiveness in terms of potential power savings. Results show that our proposal can provide significant power savings (up to 67% in a 4-ary 4-tree) with no changes in the underlying routing algorithm, with minimal impact on network performance. Experiments conducted on a 16-ary 3-tree topology provide up to 36% energy savings with performance degradation below 1.10%.

TEMPUS is the European Union (EU) programme that supports the modernisation and reform of Higher Education (HE) and promotes institutional cooperation that involves the EU and EU’s neighboring countries (PC). The PC includes Eastern Europe, Central Asia, the Western Balkans and also the Mediterranean region. The Medis Project belongs to the TEMPUS framework. The Medis project that is described in this article develops in this context.

[EN] To ensure the success of mobile learning, the use of an appropriate methodology to design and implement mobile device based on educational tools is a key issue. Industrial Computing (IC) subject is a third year compulsory subject of Industrial Electronic and Automation Engineering degree, which instructs students in the design and validation of Industrial Computing Systems (ICS) to control medium size industrial processes. IC is organized through a Problem Based Learning (PBL) methodology to carry out the implementation of ICS. In a traditional IC class, students had overheads to follow teacher's demonstrations. Students did not complete project implementation because they were unable to follow part of the explanations, and hence they get unmotivated. To solve this problem, an IC mobile device based multimedia teaching methodology, namely m-IC is developed. m-IC allows integration of lecture videos, problems, laboratories and development demonstrations of ICS projects. In this way, m-IC allows students autonomously plan their formation process and receive teacher guidance using a mobile phone. Moreover, smartphones availability makes these devices good candidates to learn IC. To show how students interact with m-IC, a smartphone application is detailed. The successful evaluation of m-IC by around 800 students during four years is presented.

This paper presents a multidisciplinary problem-based learning (PBL) project consisting of the development of a robot arm prototype and the implementation of its control system. The project is carried out as part of Industrial Informatics (II), a compulsory third-year course in the Automation and Electronic Engineering (AEE) degree program at the School of Engineering at Universitat Politècnica de València, València, Spain. The robot arm is a low-cost prototype, initially controlled with a joystick. The aim of the project is, first, to design and implement a full control system for the robot, including the necessary circuitry for microcomputer (ARM Cortex)-based control and, second, to pit the designed robot in competition against other students' robots. Incorporation of multidisciplinary PBL required changes in the organization of the course, which features various learning activities and their continuous evaluation; it also required knowledge of five other courses in the AEE program. PBL methodology is compared to a traditional method; the results obtained proved highly satisfactory. Moreover, the PBL robotic experience was highly rated by some 900 students.

NOTICE: this is the author’s version of a work that was accepted for publication in Parallel Computing. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Parallel Computing, [Volume 48, October 2015, Pages 59–80] DOI 10.1016/j.parco.2015.03.007, As higher communication bandwidth is required in current designs of high performance parallel computers, the amount of power consumed by the interconnection network also increases. Fat-tree is one of the most popular topologies in high performance interconnection networks aiming at low latency, efficient collective communication and scalability. We present a new methodology for managing power consumption of fat-tree interconnection networks. Our proposal is based on dynamically adjusting available network bandwidth according to traffic requirements. To meet this goal, we define a mechanism for managing the operating status of network links as a function of network load. Our main contributions include a complete definition of the mechanism and a tuning methodology based on its sensitivity and aggressiveness in terms of potential power savings. Results show that our proposal can provide significant power savings (up to 67% in a 4-ary 4-tree) with no changes in the underlying routing algorithm, with minimal impact on network performance. Experiments conducted on a 16-ary 3-tree topology provide up to 36% energy savings with performance degradation below 1.10%.

TEMPUS is the European Union (EU) programme that supports the modernisation and reform of Higher Education (HE) and promotes institutional cooperation that involves the EU and EU’s neighboring countries (PC). The PC includes Eastern Europe, Central Asia, the Western Balkans and also the Mediterranean region. The Medis Project belongs to the TEMPUS framework. The Medis project that is described in this article develops in this context.

En la actualidad, las pequeñas y medianas empresas, en su empeño por aprovechar al máximo posible los distintos flujos de información que se producen al llevar a cabo sus objetivos, demandan herramientas de gestión y presentación de la información cada vez más especializadas. Este proyecto versa sobre el análisis de las necesidades especiales en el área comercial de una empresa del sector del espectáculo, así como sobre el diseño, implementación e implantación de un sistema capaz de cubrirlas. Se pretende que este proyecto de Ingeniería del Software describa las distintas fases del ciclo de vida del sistema creado. Serán de especial atención las fases de diseño, con Unified Modeling Language, o UML, como herramienta principal de modelado; y también la fase de implementación, con el uso del lenguaje de programación C++ apoyado en las bibliotecas Qt como principal herramienta de desarrollo. Otras tecnologías utilizadas serán el popular sistema de gestión de bases de datos MySQL; el anticuado, pero sencillo y útil bajo ciertas consideraciones de seguridad, protocolo FTP; o el lenguaje XML, utilizado para la importación y exportación de datos entre distintas aplicaciones.

En la actualidad, las pequeñas y medianas empresas, en su empeño por aprovechar al máximo posible los distintos flujos de información que se producen al llevar a cabo sus objetivos, demandan herramientas de gestión y presentación de la información cada vez más especializadas. Este proyecto versa sobre el análisis de las necesidades especiales en el área comercial de una empresa del sector del espectáculo, así como sobre el diseño, implementación e implantación de un sistema capaz de cubrirlas. Se pretende que este proyecto de Ingeniería del Software describa las distintas fases del ciclo de vida del sistema creado. Serán de especial atención las fases de diseño, con Unified Modeling Language, o UML, como herramienta principal de modelado; y también la fase de implementación, con el uso del lenguaje de programación C++ apoyado en las bibliotecas Qt como principal herramienta de desarrollo. Otras tecnologías utilizadas serán el popular sistema de gestión de bases de datos MySQL; el anticuado, pero sencillo y útil bajo ciertas consideraciones de seguridad, protocolo FTP; o el lenguaje XML, utilizado para la importación y exportación de datos entre distintas aplicaciones.

En la actualidad, las pequeñas y medianas empresas, en su empeño por aprovechar al máximo posible los distintos flujos de información que se producen al llevar a cabo sus objetivos, demandan herramientas de gestión y presentación de la información cada vez más especializadas. Este proyecto versa sobre el análisis de las necesidades especiales en el área comercial de una empresa del sector del espectáculo, así como sobre el diseño, implementación e implantación de un sistema capaz de cubrirlas. Se pretende que este proyecto de Ingeniería del Software describa las distintas fases del ciclo de vida del sistema creado. Serán de especial atención las fases de diseño, con Unified Modeling Language, o UML, como herramienta principal de modelado; y también la fase de implementación, con el uso del lenguaje de programación C++ apoyado en las bibliotecas Qt como principal herramienta de desarrollo. Otras tecnologías utilizadas serán el popular sistema de gestión de bases de datos MySQL; el anticuado, pero sencillo y útil bajo ciertas consideraciones de seguridad, protocolo FTP; o el lenguaje XML, utilizado para la importación y exportación de datos entre distintas aplicaciones.

[Otro] Cie¿om práce je posúdi¿ vplyv veku a emo¿nej valencie na znovupoznávanie slov v rámci ex-Gaussových distribu¿ných komponentov. Dvom vekovým skupinám sme administrovali test znovupoznávania slov, v ktorom sme manipulovali emo¿nou valenciou. U mladších respondentov sa prejavili štatisticky signifikantné rozdiely pri negatívnych slovách v experimentálnej podmienke a v podmienke s distrakciou. U starších respondentov sme v odpove¿ových ¿asoch nezistili jasnú tendenciu. Vzh¿adom na ex-Gaussovský parameter ¿, ktorý sa v literatúre ¿asto spája s nárokmi na pozornos¿, vekovo podmienené rozdiely v emo¿nej valencii nemali žiaden vplyv na negatívne slová. Ak sa zameriame na emo¿nú valenciu v oboch skupinách, u mladších respondentov sa prejavil vplyv v negatívnych distrak¿ných slovách. U starších respondentov sa prejavil vplyv v negatívnych a pozitívnych cie¿ových slovách a negatívnych distrak¿ných slovách. Z toho vyplýva, že nároky na pozornos¿ sú vyššie pre emo¿ne nabité slová, najmä u starších respondentov., [EN] The aim of this work is to evaluate the roles of age and emotional valence in word recognition in terms of ex-Gaussian distribution components. In order to do that, a word recognition task was carried out with two age groups, in which emotional valence was manipulated. Older participants did not present a clear trend for reaction times. The younger participants showed significant statistical differences in negative words for target and distracting conditions. Addressing the ex-Gaussian ? parameter, often related to attentional demands in the literature, age-related differences in emotional valence seem not to have an effect for negative words. Focusing on emotional valence for each group, the younger participants only showed an effect on negative distracting words. The older participants showed an effect regarding negative and positive target words, and negative distracting words. This suggests that the attentional demand is higher for emotional words, in particular, for the older participants.

[Otro] Cie¿om práce je posúdi¿ vplyv veku a emo¿nej valencie na znovupoznávanie slov v rámci ex-Gaussových distribu¿ných komponentov. Dvom vekovým skupinám sme administrovali test znovupoznávania slov, v ktorom sme manipulovali emo¿nou valenciou. U mladších respondentov sa prejavili štatisticky signifikantné rozdiely pri negatívnych slovách v experimentálnej podmienke a v podmienke s distrakciou. U starších respondentov sme v odpove¿ových ¿asoch nezistili jasnú tendenciu. Vzh¿adom na ex-Gaussovský parameter ¿, ktorý sa v literatúre ¿asto spája s nárokmi na pozornos¿, vekovo podmienené rozdiely v emo¿nej valencii nemali žiaden vplyv na negatívne slová. Ak sa zameriame na emo¿nú valenciu v oboch skupinách, u mladších respondentov sa prejavil vplyv v negatívnych distrak¿ných slovách. U starších respondentov sa prejavil vplyv v negatívnych a pozitívnych cie¿ových slovách a negatívnych distrak¿ných slovách. Z toho vyplýva, že nároky na pozornos¿ sú vyššie pre emo¿ne nabité slová, najmä u starších respondentov., [EN] The aim of this work is to evaluate the roles of age and emotional valence in word recognition in terms of ex-Gaussian distribution components. In order to do that, a word recognition task was carried out with two age groups, in which emotional valence was manipulated. Older participants did not present a clear trend for reaction times. The younger participants showed significant statistical differences in negative words for target and distracting conditions. Addressing the ex-Gaussian ? parameter, often related to attentional demands in the literature, age-related differences in emotional valence seem not to have an effect for negative words. Focusing on emotional valence for each group, the younger participants only showed an effect on negative distracting words. The older participants showed an effect regarding negative and positive target words, and negative distracting words. This suggests that the attentional demand is higher for emotional words, in particular, for the older participants.

The use of IT technologies plays an important role in the training of future engineers. In this paper, smartphones and multimedia technologies are proposed as an innovative way to tackle the formation of students, at different levels, in the Industrial Informatics (II) subject of the Industrial Electronics Engineering (IEE) degree. II instructs future Engineers in the design of IT systems to control industrial processes. In the first level, smartphones are used to display a web-based multimedia tool that is implemented to register the lecture explanations regarding the design of II systems, so as it facilitates student to guide him/her self in the learning process. In the second level, the smartphone is proposed as the control system of a medium size industrial process (e.g., water tank). Since II uses a problem-based learning methodology (miniproject) to instruct the design of II systems, for each lecture, laboratory practices are tackled, and the solutions obtained are embedded in the smartphone to control the corresponding part of the miniproject. An application of the Smartphone multimedia tool is presented to show how students interact with the developed system. The successful evaluation of the proposed tools, by more than 900 IEE students during three years, is shown.

Consulta en la Biblioteca ETSI Industriales (8320), [EN] A covered ice hockey rink for recreational and sporting events and entertainment is going to be built in Cracow. Building suitable for this kind of sports events must cover a large area, and it is advisable that the structure does not have any columns inside. A structure without columns inside permits substantial flexibility in distributing the space. This flexibility is an important characteristic, because the building should accommodate the main track and the stands. The building should have a modern appearance and good blend well whit the environment of relatively modern structures. It is important for the citizens to feel identified and attracted to a new social hub of the city quarter. Finally, a sports building must be easily accessible by means of public transport, and have ample parking space nearly, so the citizens would be able to arrive to the edifice in a few minutes. Thus the building will be located near intersection of main thoroughfares will have a very good connection with city's public transport system (regular buses and good roads). Furthermore, this building will have a large area dedicated to parking in order to accommodate a large number of private automobiles.

Consulta en la Biblioteca ETSI Industriales (8320), [EN] A covered ice hockey rink for recreational and sporting events and entertainment is going to be built in Cracow. Building suitable for this kind of sports events must cover a large area, and it is advisable that the structure does not have any columns inside. A structure without columns inside permits substantial flexibility in distributing the space. This flexibility is an important characteristic, because the building should accommodate the main track and the stands. The building should have a modern appearance and good blend well whit the environment of relatively modern structures. It is important for the citizens to feel identified and attracted to a new social hub of the city quarter. Finally, a sports building must be easily accessible by means of public transport, and have ample parking space nearly, so the citizens would be able to arrive to the edifice in a few minutes. Thus the building will be located near intersection of main thoroughfares will have a very good connection with city's public transport system (regular buses and good roads). Furthermore, this building will have a large area dedicated to parking in order to accommodate a large number of private automobiles.

The use of IT technologies plays an important role in the training of future engineers. In this paper, smartphones and multimedia technologies are proposed as an innovative way to tackle the formation of students, at different levels, in the Industrial Informatics (II) subject of the Industrial Electronics Engineering (IEE) degree. II instructs future Engineers in the design of IT systems to control industrial processes. In the first level, smartphones are used to display a web-based multimedia tool that is implemented to register the lecture explanations regarding the design of II systems, so as it facilitates student to guide him/her self in the learning process. In the second level, the smartphone is proposed as the control system of a medium size industrial process (e.g., water tank). Since II uses a problem-based learning methodology (miniproject) to instruct the design of II systems, for each lecture, laboratory practices are tackled, and the solutions obtained are embedded in the smartphone to control the corresponding part of the miniproject. An application of the Smartphone multimedia tool is presented to show how students interact with the developed system. The successful evaluation of the proposed tools, by more than 900 IEE students during three years, is shown.

El presente trabajo de investigación pretende analizar de forma cuantitativa el uso de las fuentes documentales en las noticias locales de periódicos españoles relacionadas con la temática autonómica valenciana durante el período 2006-2010. Para investigar en profundidad el uso de estas fuentes en noticias locales, se han escogido los periódicos más representativos de la Comunidad Valenciana y con mayor difusión según la Oficina de Justificación de los Medios durante el 2006: El País Comunidad Valenciana, El Mundo Valencia, Levante-EMV y Las Provincias. Para poder realizar este trabajo primero se ha debido presentar una base teórica donde se ha explicado cuál es el ejercicio de la documentación en el ámbito de la actividad periodística así como las condiciones documentales necesarias por los periodistas para poder ejecutar su trabajo. A continuación, se ha desarrollado el concepto y tipología de las fuentes de información desde el punto de vista documental. Tras la selección de los medios, lo siguiente ha sido constituir la muestra de estudio. Para ello se han escogido casos reales materializados en una selección de noticias teniendo en cuenta la condición de ser impresa en tres de los cuatro periódicos y su temática estuviera relacionada con la Comunidad Valenciana. Las noticias se han seleccionado en base a siete días correspondientes a semana construida. El corpus está configurado por tres conjuntos de noticias: uno comprendido entre 2006 y 2007 de periódicos en papel; un segundo, con los mismos días y meses durante los años 2009-2010 en soporte papel y, un tercero, con los mismos días y meses de 2009-2010 en soporte digital. Una vez constituido el corpus, el siguiente paso ha sido el de identificar y cuantificar las fuentes de información detectadas en las noticias. A continuación se ha procedido a clasificarlas en base a unos determinados criterios diseñados para esta investigación. Tras la valoración cuantitativa, se han descrito los ejemplos más sign

El presente trabajo de investigación pretende analizar de forma cuantitativa el uso de las fuentes documentales en las noticias locales de periódicos españoles relacionadas con la temática autonómica valenciana durante el período 2006-2010. Para investigar en profundidad el uso de estas fuentes en noticias locales, se han escogido los periódicos más representativos de la Comunidad Valenciana y con mayor difusión según la Oficina de Justificación de los Medios durante el 2006: El País Comunidad Valenciana, El Mundo Valencia, Levante-EMV y Las Provincias. Para poder realizar este trabajo primero se ha debido presentar una base teórica donde se ha explicado cuál es el ejercicio de la documentación en el ámbito de la actividad periodística así como las condiciones documentales necesarias por los periodistas para poder ejecutar su trabajo. A continuación, se ha desarrollado el concepto y tipología de las fuentes de información desde el punto de vista documental. Tras la selección de los medios, lo siguiente ha sido constituir la muestra de estudio. Para ello se han escogido casos reales materializados en una selección de noticias teniendo en cuenta la condición de ser impresa en tres de los cuatro periódicos y su temática estuviera relacionada con la Comunidad Valenciana. Las noticias se han seleccionado en base a siete días correspondientes a semana construida. El corpus está configurado por tres conjuntos de noticias: uno comprendido entre 2006 y 2007 de periódicos en papel; un segundo, con los mismos días y meses durante los años 2009-2010 en soporte papel y, un tercero, con los mismos días y meses de 2009-2010 en soporte digital. Una vez constituido el corpus, el siguiente paso ha sido el de identificar y cuantificar las fuentes de información detectadas en las noticias. A continuación se ha procedido a clasificarlas en base a unos determinados criterios diseñados para esta investigación. Tras la valoración cuantitativa, se han descrito los ejemplos más sign

[EN] Most e-maintenance approaches are oriented to big industries and are prohibitive for modest industries. This paper proposes an architecture for e-maintenance that tries to solve this gap. This architecture defines two domains, the floor-shop and the cloud domain. In the floor-shop domain, a mobile device is connected to the system to be maintained by means of a tether-free process interface. On the other hand, the cloud domain provides the resources to improve the maintenance in instrumented manufacturing systems via Internet connection. Also, the mobile device is responsible for joining both domains through its Internet capabilities. The proposed architecture combines mobile devices, cloud computing and Internet connectivity, allowing fresh technicians to supply its lack of expertise, reducing maintenance task time and minimizing the expert technician dependency. The expert now changes his role because his physical presence at the floor-shop domain is not required, being his know-how incorporated to the system. The proposal is human-centric, providing an intuitive usability such as any typical smartphone app. The results show that it is feasible to reduce drastically the economic requirements for deploying complex e-maintenance infrastructures, increasing the quality of the maintenance and enabling the applicability to small factories where maintenance is mostly outsourced. This is translated to higher availability and productivity of the manufacturing plant.

[EN] Most e-maintenance approaches are oriented to big industries and are prohibitive for modest industries. This paper proposes an architecture for e-maintenance that tries to solve this gap. This architecture defines two domains, the floor-shop and the cloud domain. In the floor-shop domain, a mobile device is connected to the system to be maintained by means of a tether-free process interface. On the other hand, the cloud domain provides the resources to improve the maintenance in instrumented manufacturing systems via Internet connection. Also, the mobile device is responsible for joining both domains through its Internet capabilities. The proposed architecture combines mobile devices, cloud computing and Internet connectivity, allowing fresh technicians to supply its lack of expertise, reducing maintenance task time and minimizing the expert technician dependency. The expert now changes his role because his physical presence at the floor-shop domain is not required, being his know-how incorporated to the system. The proposal is human-centric, providing an intuitive usability such as any typical smartphone app. The results show that it is feasible to reduce drastically the economic requirements for deploying complex e-maintenance infrastructures, increasing the quality of the maintenance and enabling the applicability to small factories where maintenance is mostly outsourced. This is translated to higher availability and productivity of the manufacturing plant.