1. Local and Remote Postconditioning Decrease Intestinal Injury in a Rabbit Ischemia/Reperfusion Model
- Author
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Jian-Xin Dong, Mu Yang, Fu-bo Song, Tao Wang, Jun Yong, Jv-Wen Zhang, Lubin Li, and Haijie Che
- Subjects
medicine.medical_specialty ,Article Subject ,Hepatology ,business.industry ,Intestinal ischemia ,Gastroenterology ,Ischemia ,030204 cardiovascular system & hematology ,Pharmacology ,medicine.disease_cause ,medicine.disease ,Surgery ,03 medical and health sciences ,High morbidity ,0302 clinical medicine ,Apoptosis ,030220 oncology & carcinogenesis ,Intestinal injury ,medicine ,lcsh:Diseases of the digestive system. Gastroenterology ,Injury model ,lcsh:RC799-869 ,business ,Oxidative stress ,Research Article - Abstract
Intestinal ischemia/reperfusion (I/R) injury is a significant problem that is associated with high morbidity and mortality in critical settings. This injury may be ameliorated using postconditioning protocol. In our study, we created a rabbit intestinal I/R injury model to analyze the effects of local ischemia postconditioning (LIPo) and remote ischemia postconditioning (RIPo) on intestinal I/R injury. We concluded that LIPo affords protection in intestinal I/R injury in a comparable fashion with RIPo by decreasing oxidative stress, neutrophil activation, and apoptosis.
- Published
- 2015