1. Regulation of Metabolic Disease-Associated Inflammation by Nutrient Sensors.
- Author
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Yamashita AS, Belchior T, Lira FS, Bishop NC, Wessner B, Rosa JC, and Festuccia WT
- Subjects
- Animals, Fatty Acids, Monounsaturated metabolism, Humans, Inflammation complications, Insulin metabolism, Intra-Abdominal Fat metabolism, Mechanistic Target of Rapamycin Complex 1 metabolism, Metabolic Diseases, Mice, Obesity metabolism, Signal Transduction, Diabetes Mellitus, Type 2 metabolism, Insulin Resistance, Insulin-Secreting Cells metabolism, Nutrients
- Abstract
Visceral obesity is frequently associated with the development of type 2 diabetes (T2D), a highly prevalent chronic disease that features insulin resistance and pancreatic β -cell dysfunction as important hallmarks. Recent evidence indicates that the chronic, low-grade inflammation commonly associated with visceral obesity plays a major role connecting the excessive visceral fat deposition with the development of insulin resistance and pancreatic β -cell dysfunction. Herein, we review the mechanisms by which nutrients modulate obesity-associated inflammation.
- Published
- 2018
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