1. The vitamin D receptor (VDR) gene polymorphisms in Turkish brain cancer patients.
- Author
-
Toptaş B, Kafadar AM, Cacina C, Turan S, Yurdum LM, Yiğitbaşı N, Gökçe MO, Zeybek U, and Yaylım I
- Subjects
- Adult, Case-Control Studies, Demography, Gene Frequency genetics, Glioma genetics, Haplotypes genetics, Humans, Meningioma genetics, Middle Aged, Risk Factors, Turkey, Brain Neoplasms genetics, Genetic Predisposition to Disease, Polymorphism, Genetic, Receptors, Calcitriol genetics
- Abstract
Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP). Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles. Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.
- Published
- 2013
- Full Text
- View/download PDF