1. Sex-associated expression of co-stimulatory molecules CD80, CD86, and accessory molecules, PDL-1, PDL-2 and MHC-II, in F480+ macrophages during murine cysticercosis.
- Author
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Togno-Peirce C, Nava-Castro K, Terrazas LI, and Morales-Montor J
- Subjects
- Animals, B7-1 Antigen immunology, B7-2 Antigen immunology, Cysticercosis immunology, Cysticercosis parasitology, Disease Susceptibility, Female, Gene Expression Regulation, Macrophage Activation immunology, Macrophages, Peritoneal immunology, Male, Mice, Sex Characteristics, Taenia immunology, Taenia metabolism, Taenia pathogenicity, B7-1 Antigen metabolism, B7-2 Antigen metabolism, B7-H1 Antigen metabolism, Cysticercosis metabolism, H-2 Antigens metabolism, Macrophages, Peritoneal metabolism, Programmed Cell Death 1 Ligand 2 Protein metabolism
- Abstract
Macrophages are critically involved in the interaction between T. crassiceps and the murine host immune system. Also, a strong gender-associated susceptibility to murine cysticercosis has been reported. Here, we examined the sex-associated expression of molecules MHC-II, CD80, CD86, PD-L1, and PD-L2 on peritoneal F4/80(hi) macrophages of BALB/c mice infected with Taenia crassiceps. Peritoneal macrophages from both sexes of mice were exposed to T. crassiceps total extract (TcEx). BALB/c Females mice recruit higher number of macrophages to the peritoneum. Macrophages from infected animals show increased expression of PDL2 and CD80 that was dependent from the sex of the host. These findings suggest that macrophage recruitment at early time points during T. crassiceps infection is a possible mechanism that underlies the differential sex-associated susceptibility displayed by the mouse gender.
- Published
- 2013
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