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Your search keyword '"Yang, Hye-Jeong"' showing total 11 results
Start Over Author "Yang, Hye-Jeong" Publisher hindawi limited
11 results on '"Yang, Hye-Jeong"'

1. Immune-Enhancing Activity of Vitis coignetiae Extract via Increasing Cytokine and Natural Killer Cell Activity in Splenocytes and Cyclophosphamide-Induced Immunosuppressed Rats

Author

Park, Young Mi, primary, Lee, Hak Yong, additional, Shin, Dong Yeop, additional, Jeong, Han Na, additional, Hwang, Hai Min, additional, Park, Hyo Yeon, additional, Kim, Suk Hun, additional, Kim, Min Ji, additional, Kang, Hee Joo, additional, Kim, Jin Hee, additional, Kim, Myung-sunny, additional, Yang, Hye Jeong, additional, Kim, Min Jung, additional, and Kim, Jae Gon, additional

Published
2024
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5. Gastrodia elata Blume Rhizome Aqueous Extract Improves Arterial Thrombosis, Dyslipidemia, and Insulin Response in Testosterone-Deficient Rats.

Author

Kim, Min Jung, Yang, Hye Jeong, Moon, Bo Reum, Kim, Ji Eun, Kim, Kang Sung, and Park, Sunmin

Subjects
*ANIMAL experimentation, *DIET, *HYPERLIPIDEMIA, *INSULIN, *RESEARCH methodology, *RATS, *TESTOSTERONE, *THROMBOSIS, THERAPEUTIC use of plant extracts
Abstract

Testosterone deficiency deteriorates glucose and lipid metabolism with reducing muscle mass. We investigated whether the consumption of water extracts of Gastrodia elata Blume rhizome (GEB) rich in gastrodin would reduce the symptoms of testosterone deficiency and improve blood flow in orchidectomized (ORX) rats. ORX rats were given high-fat diets supplemented with either 1% cellulose (ORX-control), 0.3% GEB (GEB-L), or 1% GEB (GEB-H) for 8 weeks. Sham-operated rats were fed the same diet as OVX-control rats (normal-control). ORX-control rats had reduced serum testosterone levels by one-fifth, compared to normal-control rats. ORX-control rats exhibited decreased lean body mass, attenuated blood flow, and impaired cholesterol metabolism and glucose control due to decreased insulin secretory response. GEB increased serum insulin levels dose-dependently and GEB-H mostly enhanced dyslipidemia in ORX rats. GEB completely normalized arterial thrombosis time and blood flow in ORX rats. Interestingly, ORX-control rats showed attenuated hepatic insulin signaling but greater AMPK and CREB activities, which reduced triglyceride accumulation, compared to normal-control. GEB-H improved hepatic insulin signaling but maintained the AMPK and CREB activities in ORX rats. In conclusions, GEB ameliorated the impairment of cholesterol and glucose metabolism and blood flow in ORX rats. GEB may be a potential preventive measure for reducing the risk of cardiovascular diseases associated with testosterone deficiency. [ABSTRACT FROM AUTHOR]

Published
2017
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