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The density of CD169+ macrophages has been reported to positively correlate with the number of CD8+ T cells, although this remains controversial. To better understand this topic, we conducted a meta-analysis. We searched the PubMed, Medline, and Web of Science databases for studies that were published before May 2022 and performed a meta-analysis of the incidence of low and high CD169 expression in groups based on CD8 expression using the random-effects model. A total of 10 studies were included in the meta-analysis. The incidence of high CD169 expression in lymph nodes was significantly lower than that of low CD169 expression in the low CD8 expression group (odds ratio (OR): 0.76, 95% confidence interval (CI): 0.6, 0.96); however, the incidence of high CD169 expression in lymph nodes was higher than that of low CD169 expression in the high CD8 expression group (OR: 1.50, 95% CI: 1.08, 2.07). We also found that the expression of CD169 in tumors was lower than that in nontumor tissues (standardized mean difference: −5.29, 95% CI: −7.47, −3.11). The overall survival and hazard ratio of patients with high and low CD169 expression was 0.45 (95% CI: 0.37, 0.55). This analysis showed that high CD169 expression was associated with a high CD8 expression, and low CD169 expression was associated with low CD8 expression. The risk of death was 55% lower for patients with high CD169 expression, and high CD169 expression may be associated with favorable survival outcomes in cancer patients. However, the number and heterogeneity of the studies should be taken into consideration when evaluating the analysis. High-quality randomized controlled trials on the association between CD169 and CD8 expression are needed to verify these effects. [ABSTRACT FROM AUTHOR]

Low energy consumption and green transformation of automobile product portfolio is the trend of the times. Automotive manufacturers make product portfolio decisions by setting multiple criteria such as fuel consumption, sales, and volume. It is also important to take into account the symbiotic interaction effects between automotive products. In order to achieve the above research objectives, this paper constructs the Lotka–Volterra MCGP model to make multicriteria decisions on automobile product portfolio design from the perspective of energy sustainability with BMW Brilliance is taken as an example to illustrate the process of using the multicriteria model. The empirical analysis successively measures product growth using the logistic model, analyzes the symbiotic relationship of product portfolios using the Lotka–Volterra model, and finally performs multicriteria evaluation using the MCGP model. In order to verify the reliability of the model, this paper verifies the robustness of the model from the perspectives of parameter dynamics, system boundaries, and model scalability. The results of empirical analysis and robustness analysis show that the Lotka–Volterra MCGP model proposed in this paper is applicable to the multicriteria decision-making of automobile product portfolio design from the perspective of energy sustainability. [ABSTRACT FROM AUTHOR]

The Huayu-Qiangshen-Tongbi (HQT) decoction, a Chinese medical formula, has been identified to show a potent therapeutic effect on rheumatoid arthritis (RA). However, the specific molecular mechanism of HQT in RA has not been well studied. In the present study, LPS-treated human rheumatoid fibroblast-like synoviocyte (FLS) MH7A cells and collagen-induced arthritis (CIA) mice were utilized as in vitro and in vivo models. Our results demonstrated that HQT could efficiently inhibit RA-induced inflammation by reducing the production of cytokines including tumor necrosis factor alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). Moreover, HQT significantly upregulated the expression of miR-125b. Besides, analysis of bioinformatics suggested casein kinase 2 (CK2) was a potential target of miR-125b. Luciferase reporter assay was performed and revealed that miR-125b suppressed CK2 expression in MH7A cells. Furthermore, miR-125b inhibited LPS-induced NF-kappa-B (NF-κB) activation, which is a downstream target of CK2. In addition, the NF-κB inhibitor ammonium pyrrolidinedithiocarbamate (PDTC) and NF-kappa-B inhibitor alpha (IkB-α) enhanced the inhibitory effect of miR-125b on the expression of TNF-α, IL-1β, and IL-6. Taken together, our study revealed that HQT could attenuate RA through upregulating miR-125b to suppress NF-κB-induced inflammation by targeting CK2. The findings of this study should facilitate investigating the mechanism of HQT on RA and discovering novel therapeutic targets for RA. [ABSTRACT FROM AUTHOR]

Excessive heat losses and water consumption in cooling units are significant constraints restricting the application circumstances and performances for the SCO2 Brayton cycle, and the heat exchange capacity in the precooler (PRC) is typically 1.5 times that of power generation. Therefore, this research offers a high-integrated combined power/cooling system in which two waste heat exchangers (WHEs) and a rectifier (RET) are used instead of the PRC to achieve 100% exhaust heat recovery. Each component's energy and exergy models are developed, and the operational characteristics, coupling relationships, and exergy destruction distribution are examined. Results indicate that, when compared to the Brayton cycle, the thermal and exergy efficiency is considerably increased, and the concentration difference and WHE1 pitch point difference have significant influences on system performance. Further exergoeconomic and optimization analysis reveals that the superior exergy case is mostly recommended for relevant thermal and exergy efficiency increasing rates of 13.7% and 9.17%, respectively, and the unit cost is 81.33% that of the base case. Turbine 1 (TUR1) and main compressor (MCP) are the first and second highest cost rates, respectively, and RET and generator (GEN) account for roughly 34% exergy destruction rate and 20% exergy destruction cost rate, respectively. In addition, reducing heat transfer differences in relevant equipment can further promote system performance. [ABSTRACT FROM AUTHOR]