1. Common Protective Strategies in Neurodegenerative Disease: Focusing on Risk Factors to Target the Cellular Redox System
- Author
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Marika Cordaro, Emma Ristori, Raffaella Molteni, Vittoria Spero, Giulia Sita, Marco Malaguti, Marina Ziche, Silvana Hrelia, Angela Marino, Patrizia Hrelia, Fabiana Morroni, and Patrizia Hrelia, Giulia Sita, Marina Ziche, Emma Ristori, Angela Marino, Marika Cordaro, Raffaella Molteni, Vittoria Spero, Marco Malaguti, Fabiana Morroni, Silvana Hrelia
- Subjects
Adult ,Aging ,Adolescent ,Inflammation ,Review Article ,Disease ,medicine.disease_cause ,Biochemistry ,Young Adult ,Risk Factors ,Glycation ,medicine ,Animals ,Humans ,Aged ,Aged, 80 and over ,QH573-671 ,business.industry ,Mechanism (biology) ,Neurodegeneration ,Neurodegenerative Diseases ,Cellular redox ,Cell Biology ,General Medicine ,Human brain ,Middle Aged ,nessuna ,medicine.disease ,medicine.anatomical_structure ,medicine.symptom ,business ,Cytology ,Oxidation-Reduction ,Neuroscience ,Oxidative stress - Abstract
Neurodegenerative disease is an umbrella term for different conditions which primarily affect the neurons in the human brain. In the last century, significant research has been focused on mechanisms and risk factors relevant to the multifaceted etiopathogenesis of neurodegenerative diseases. Currently, neurodegenerative diseases are incurable, and the treatments available only control the symptoms or delay the progression of the disease. This review is aimed at characterizing the complex network of molecular mechanisms underpinning acute and chronic neurodegeneration, focusing on the disturbance in redox homeostasis, as a common mechanism behind five pivotal risk factors: aging, oxidative stress, inflammation, glycation, and vascular injury. Considering the complex multifactorial nature of neurodegenerative diseases, a preventive strategy able to simultaneously target multiple risk factors and disease mechanisms at an early stage is most likely to be effective to slow/halt the progression of neurodegenerative diseases.
- Published
- 2020