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Pasteurella multocida is a Gram-negative anaerobe that is known to colonize household pets; in fact, it has been reported to be present in a majority of cats and dogs. P multocida can cause a variety of infections in humans, of which skin infections are the most common. This article describes a case involving a 56-year-old man who developed meningitis caused by P multocida following tympanomastoidectomy. The authors discuss the treatment course and most likely route of infection in this case, and summarize the cases of P multocida-associated meningitis presented in the literature., Pasteurella multocida is a rare cause of bacterial meningitis. A 56-year-old man with several pets developed a profoundly decreased level of consciousness following left tympanomastoidectomy. Lumbar puncture produced cerebrospinal fluid with the typical findings of meningitis (low glucose, high protein, high leukocytes). Cultures from the cerebrospinal fluid and a swab of the left ear revealed Gram-negative coccobacillus identified as P multocida. The organism was sensitive to ceftriaxone, ampicillin and penicillin, and a 14-day course of intravenous penicillin was used as definitive treatment, resulting in full recovery. Although rare, P multocida should be considered as a potential cause of meningitis in patients with animal exposure, particularly in the setting of recent cranial surgery.