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The present study is related to the effects of activation energy and thermophoretic diffusion on steady micropolar fluid along with Brownian motion. The activation energy and thermal conductivity of steady micropolar fluid are also discussed. The equation of motion, angular momentum, temperature, concentration, and their boundary conditions are presented for the micropolar fluid. The detail of geometry reveals the effects of several parameters on the parts of the system. The nonlinear partial differential equations are converted into nonlinear ordinary differential equations, and a famous shooting scheme is used to present the numerical solutions. The comparison of the obtained results by the shooting technique and the numerical bvp4c technique is presented. The behavior of local skin friction numbers and couple stress number is tabulated for different parameters, and some figures are plotted to present the different parameters. For uplifting the values of AE for parameter λA, the concentration profile is increased because of the Arrhenius function, and AE increases with the reduction of this function. The increasing values of the parameter of rotation G show the decrement in velocity because of the rotation of the particle of the fluid, so the linear motion decreases. Thermophoresis is responsible for shifting the molecules within the fluid, and due to this, an increment in boundary layer thickness is found, so by a greater value of Nt, the concentration profile decreases and temperature profile goes down.