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Array CGH was used to identify recurrentcopy number alterations (RCNA) characteristic of eitherBRCA1-related or sporadic ovarian cancer. After pre-processing, both groups of patients were modeled using arecurrent Hidden Markov Model to detect RCNA.RCNA with a probability higher than 80% were called.After removing RCNA present in both groups, the genespresent in the remaining RCNA were investigated forenrichment of pathways from external databases. MoreRCNA were observed in the BRCA1 group, and theydisplay more losses than gains compared to the sporadicgroup. When focusing on the type of RCNA, nosignificant difference in length was seen for the gains,but there was a statistically significant difference for thelosses. In the sporadic group, a great proportion of thealtered regions contain genes known to have a function incell adhesion and complement activation, whereas theBRCA1 samples are characterized by alterations in theHOX genes, metalloproteinases, tumor suppressor genes,and the estrogen-signaling pathways. We conclude thatBRCA1 ovarian tumors present a different type, number,and length of RCNA; a huge amount of the genome islost, resulting in important genomic instability. Moreover,important biological pathways are altered differentiallywhen compared to the sporadic group.Hum Mutat 30:1693–1702,2009. &2009 Wiley-Liss, Inc.KEY WORDS: array CGH; BRCA1; ovarian cancer;hidden Markov model; recurrent copy number alterations

We will describe a case of a patient diagnosed with a rare identity of a benign lesion, "reactive nodular fibrous pseudotumor" (RNFP). It is a tumor which preoperatively can present as a malignant tumor and is only reported in 19 cases. According to the very limited amount of information on this tumor in the literature it is mostly seen after trauma or intraperitoneal inflammation. Our case is the second one of RNFP associated with endometriosis, which is a frequently seen intraperitoneal inflammation process in women. Knowledge that these large pseudotumoral lesions can occur is important to direct the management of these patients. ispartof: Case reports in obstetrics and gynecology vol:2014 pages:421234- ispartof: location:United States status: published

Alimentary tract duplications are rare congenital anomalies. They most often become symptomatic in childhood and rarely undergo malignant transformation. Pseudomyxoma peritonei (PMP) is an equally uncommon condition, most frequently originating from a primary appendiceal mucinous neoplasm. We report an extremely unusual case of PMP arising from an intestinal duplication. A 67-year-old woman presented with vague upper abdominal pain, and, unexpectedly, explorative laparoscopy revealed diffuse jelly-like peritoneal implants. The histopathological diagnosis of a low-grade PMP or “disseminated peritoneal adenomucinosis” was made. At that moment, no primary tumor was found. During later surgery, a cystic lesion located in the mesentery of the small bowel could be resected. Histologically, the cyst wall clearly showed the concentric layering of a normal bowel wall. The mucosa, however, displayed a diffuse low-grade villous adenoma. We concluded that this histological picture was most consistent with a small intestinal duplication, containing a low-grade villous adenoma. The adenoma caused a mucocele, which subsequently leaked or ruptured, giving rise to noninvasive mucinous peritoneal implants or low-grade PMP, also known as “disseminated peritoneal adenomucinosis” (DPAM).