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2 results on '"Nathaniel M. Robbins"'

1. A Novel SPAST/SPG4 Splice-Site Variant in a Family with Dominant Hereditary Spastic Paraplegia

Author

Nathaniel M. Robbins, Jillian R. Ozmore, Thomas L. Winder, Pedro Gonzalez-Alegre, and Tanya M. Bardakjian

Subjects
Neurology. Diseases of the nervous system, RC346-429
Abstract

Some causes of spastic paraplegia are treatable and many are not. Diagnostic work-up to determine the etiology can be costly and invasive. Here we report the case of a man with slowly progressive spastic paraparesis. Using a multigene next-generation sequencing (NGS) panel, we identified a novel variant in the consensus splice site of the SPAST gene (exon 13, c.1536G>A, heterozygous), affecting codon 512 of the SPAST mRNA. The observed variant segregated with the disease in four tested family members. In this case, genetic confirmation obviated the need for additional testing such as MRI and lumbar puncture and helped the patient and his family understand his condition and prognosis. We conclude with a brief discussion of the SPG4/SPAST gene and the role of multigene panels in the diagnosis and management of hereditary spastic paraplegia.

Published
2020
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2. A Novel SPAST/SPG4 Splice-Site Variant in a Family with Dominant Hereditary Spastic Paraplegia

Author

Thomas L Winder, Jillian R Ozmore, Tanya Bardakjian, Nathaniel M. Robbins, and Pedro Gonzalez-Alegre

Subjects
0303 health sciences, medicine.diagnostic_test, Hereditary spastic paraplegia, Lumbar puncture, business.industry, Case Report, Disease, medicine.disease, Bioinformatics, 03 medical and health sciences, Exon, 0302 clinical medicine, 030220 oncology & carcinogenesis, RNA splicing, medicine, Spastic, Etiology, Neurology. Diseases of the nervous system, RC346-429, General Agricultural and Biological Sciences, business, Paraplegia, 030304 developmental biology
Abstract

Some causes of spastic paraplegia are treatable and many are not. Diagnostic work-up to determine the etiology can be costly and invasive. Here we report the case of a man with slowly progressive spastic paraparesis. Using a multigene next-generation sequencing (NGS) panel, we identified a novel variant in the consensus splice site of the SPAST gene (exon 13, c.1536G>A, heterozygous), affecting codon 512 of the SPAST mRNA. The observed variant segregated with the disease in four tested family members. In this case, genetic confirmation obviated the need for additional testing such as MRI and lumbar puncture and helped the patient and his family understand his condition and prognosis. We conclude with a brief discussion of the SPG4/SPAST gene and the role of multigene panels in the diagnosis and management of hereditary spastic paraplegia.

Published
2020

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