1. Lipoprotein-associated phospholipase A2 levels are associated with erectile dysfunction in patients without known coronary artery disease
- Author
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A. İnal, Mustafa Cekmen, Murat Dursun, Feti Tulubas, Emin Ozbek, Ismail Koklu, Alper Otunctemur, Huseyin Besiroglu, and Suleyman Sahin
- Subjects
Male ,medicine.medical_specialty ,Urology ,Logistic regression ,Gastroenterology ,Pathogenesis ,Endocrinology ,Phospholipase A2 ,Erectile Dysfunction ,Internal medicine ,Humans ,Medicine ,In patient ,Prospective Studies ,Endothelial dysfunction ,biology ,business.industry ,Lipoprotein-associated phospholipase A2 ,General Medicine ,Middle Aged ,medicine.disease ,Erectile dysfunction ,Case-Control Studies ,1-Alkyl-2-acetylglycerophosphocholine Esterase ,Immunology ,biology.protein ,Colorimetry ,lipids (amino acids, peptides, and proteins) ,business ,Lipoprotein - Abstract
Endothelial dysfunction and microvascular damage play a crucial role in the pathogenesis of erectile dysfunction (ED). Lp-PLA2 is a calcium-independent member of the phospholipase A2 family and hydrolyses oxidised phospholipids on low-density lipoprotein (LDL) particles that plays a pivotal role in ox-LDL-induced endothelial dysfunction. The purpose of the current study was to determine the association between Lp-PLA2 levels and ED in patients without known coronary artery disease (CAD). All patients were evaluated for ED and divided into two groups: 88 patients suffering from ED for >1 year were enrolled as an experimental group and 88 patients without ED were enrolled as a control group in this study. Diagnosis of ED was based on the International Index of Erectile Function Score-5. Levels of Lp-PLA2 were measured in serum by colorimetric assay. The relationship between Lp-PLA2 levels and ED in patients was evaluated statistically. The mean age of patients with ED group was 59.4 ± 11.32 and 55.8 ± 9.67 in the control group. Plasma Lp-PLA2 levels were significantly higher in ED than in the control group (220.3 ± 66.90 and 174.8 ± 58.83 pg ml(-1) , respectively, P < 0.001). The Lp-PLA2 levels were negatively correlated with score of ED (r = -0.482, P < 0.05). In logistic regression analysis, enhanced plasma Lp-PLA2 levels result in approximately 1.2-fold increase in ED [1.22 (1.25-2.76)]. In this study, serum Lp-PLA2 levels were found to be associated with endothelial dysfunction predictive of ED. Serum Lp-PLA2 level appears to be a specific predictor of ED, and it may be used in early prediction of ED in the male population.
- Published
- 2014